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公开(公告)号：US20240132758A1
公开(公告)日：2024-04-25
申请号：US18535124
申请日：2023-12-11
发明人： Xuanhe Zhao , Hyunwoo Yuk , Xinyu Mao , Christoph Nabzdyk
IPC分类号： C09J105/08 , A61L24/00 , C09J9/00 , C09J11/06 , C09J133/02 , C09J151/00
CPC分类号： C09J105/08 , A61L24/0042 , A61L24/0094 , C09J9/00 , C09J11/06 , C09J133/02 , C09J151/003 , A61L2400/04 , C09J2483/00
摘要： A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.
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公开(公告)号：US20230310698A1
公开(公告)日：2023-10-05
申请号：US18000872
申请日：2021-07-27
发明人： Sander Cornelis Gerardus LEEUWENBURGH , Jan Cornelis Maria VAN HEST , Maria Jose SANCHEZ-FERNANDEZ , Rosa Pilar Felix LANAO , Joost OPSTEEN , Johannes Caspar Mathias Elizabeth BENDER
CPC分类号： A61L24/0094 , A61L15/58 , A61L24/0036 , A61L2430/02
摘要： The invention relates to a biocompatible, flexible, bone-adhesive sheet that may suitably be applied in the treatment of bone defects, said bone-adhesive sheet comprising:
a cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space;
distributed within the interstitial space, (i) a plurality of polymer particles comprising a water-soluble calcium-binding polymer, said water-soluble calcium-binding polymer carrying at least one calcium binding group or (ii) a plurality of reactive particles comprising an electrophilically activated water-soluble polymer and a plurality of bisphosphonate particles comprising nitrogenous bisphosphonate.-
公开(公告)号：US11643574B2
公开(公告)日：2023-05-09
申请号：US17338951
申请日：2021-06-04
申请人： Cohesys Inc.
发明人： Michael C. Floros , Latchmi Raghunanan , Alexander J. Lausch , Janaina Freitas Bortolatto , Bryan Donovan Quan
IPC分类号： A61L24/04 , A61L24/02 , C08L75/00 , C09J7/25 , C08L53/00 , C08L67/04 , C09J7/35 , C09J11/04 , A61L24/00 , C08G63/685 , C08K3/32
CPC分类号： C09J7/255 , A61L24/0042 , A61L24/0094 , A61L24/02 , A61L24/043 , C08G63/6852 , C08K3/32 , C08L53/00 , C08L67/04 , C09J7/35 , C09J11/04 , C08K2003/325 , C09J2301/304 , C09J2301/408 , C09J2400/163 , C09J2467/00 , C09J2467/006 , A61L24/043 , C08L53/00 , A61L24/043 , C08L67/04
摘要： The invention features adhesive devices for holding objects (e.g., bone fragments) fixed with respect to each other.
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4.发明申请公开(公告)号：US20180256778A1
公开(公告)日：2018-09-13
申请号：US15976615
申请日：2018-05-10
CPC分类号： A61L24/102 , A61B17/866 , A61B2017/564 , A61B2017/8655 , A61F2/2846 , A61F2/30723 , A61F2/30734 , A61F2/30907 , A61F2/3601 , A61F2002/30736 , A61F2002/30919 , A61F2310/00011 , A61K38/1841 , A61K38/1875 , A61L24/0015 , A61L24/0089 , A61L24/0094 , A61L24/02 , A61L24/06 , A61L24/108 , A61L2300/102 , A61L2300/252 , A61L2300/404 , A61L2300/414 , A61L2400/12 , A61L2430/02 , C08L33/12 , C08L67/04
摘要： The present invention provides processes for combined applications of making grooves on an implant surface, applying MgO nanoparticles with PMMA cement, restricting the cement movement by PCL nanofiber and tethering biomolecules with PCL nanofiber to enhance mechanical stability and osseointegration of PMMA cement with bone. This is achieved through enhanced osteoconductive properties, roughness, and less viable fracture originating sites at the bone-cement interface. Such combined applications of nanoparticle and nanofiber on the mechanical stability and osseointegration of cemented implant is heretofore unknown, but as provided by the present invention can solve the debonding problem of cemented implant from bone.
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公开(公告)号：US09956314B2
公开(公告)日：2018-05-01
申请号：US15006228
申请日：2016-01-26
申请人： Modern Ideas LLC
发明人： Sunny Skaria , Kenneth Berk
CPC分类号： A61L24/06 , A61K6/0017 , A61K6/0023 , A61K6/0047 , A61K6/0082 , A61K6/0091 , A61K6/0835 , A61L24/0089 , A61L24/0094 , A61L24/043 , C08L33/10 , C08L85/02
摘要： An adhesive composition for bonding to bone and bone-like structures includes a polymerizable, multifunctional acidic monomer having a concentration ranging from about 5% to about 45% by weight of the adhesive composition, one or more multifunctional monomers with one or more ethylenically unsaturated groups having a concentration ranging from about 20% to about 60% by weight of the adhesive composition, an organically modified calcium phosphate salt with one or more pendant polymerizable groups having a concentration ranging from about 1% to about 50% by weight of the adhesive composition, and a polymerization initiator system. A method of forming the adhesive composition is also provided.
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公开(公告)号：US09919074B2
公开(公告)日：2018-03-20
申请号：US13406489
申请日：2012-02-27
IPC分类号： A61K47/10 , C08L71/02 , C09D171/02 , C09J171/02 , A61L27/18 , A61K9/00 , A61K31/765 , A61L24/00 , A61L24/04 , A61L27/26 , A61L27/46 , A61L27/48 , C08L53/00 , C09J153/00 , C11D3/37
CPC分类号： A61L27/18 , A61K9/0014 , A61K9/0019 , A61K31/765 , A61K47/10 , A61L24/0084 , A61L24/0094 , A61L24/046 , A61L27/26 , A61L27/46 , A61L27/48 , C08L53/00 , C08L71/02 , C08L2666/02 , C08L2666/14 , C09J153/00 , C11D3/3707 , Y10S606/91 , C08L23/06
摘要： A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homo-polymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.
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公开(公告)号：US20160317697A1
公开(公告)日：2016-11-03
申请号：US15181280
申请日：2016-06-13
CPC分类号： A61L15/44 , A61F13/00063 , A61F2013/0011 , A61L15/18 , A61L15/225 , A61L15/26 , A61L15/325 , A61L15/425 , A61L24/0036 , A61L24/0094 , A61L2300/232 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2420/02 , C12Y304/21005
摘要： The present invention provides a hemostatic porous composite sponge comprising: i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.
摘要翻译： 本发明提供一种止血多孔复合海绵，其包括i）生物材料的基质和ii）包含反应性基团的一种亲水性聚合物组分，其中i）和ii）彼此相关联，使得保留聚合物组分的反应性，其中 所述聚合物组分被涂覆在生物材料的所述基体的表面上，或 - 所述基质用所述聚合物材料浸渍，或 - 两者。
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公开(公告)号：US20160158405A1
公开(公告)日：2016-06-09
申请号：US14903803
申请日：2014-07-09
发明人： Stephen Denyer , Samuel Evans , Wayne Ayre
IPC分类号： A61L24/00 , A61K31/7036 , A61L24/04 , A61K9/127
CPC分类号： A61L24/0015 , A61K9/1271 , A61K31/7036 , A61L24/0094 , A61L24/046 , A61L27/54 , A61L2300/23 , A61L2300/406 , A61L2300/626 , A61L2430/02 , C08L33/12
摘要： The invention relates to a novel antibiotic delivery vehicle for impregnating bone cement wherein said vehicle is an antibiotic encapsulated liposome having a block co-polymer on its surface; a method for the manufacture of a bone cement impregnated with antibiotic or a mixture of antibiotics using said vehicle; and also a novel bone cement made therewith and/or thereby.
摘要翻译： 本发明涉及一种用于浸渍骨水泥的新型抗生素递送载体，其中所述载体是其表面上具有嵌段共聚物的抗生素包封的脂质体; 使用所述载体制造浸渍有抗生素或抗生素混合物的骨水泥的方法; 以及由此制成的新型骨水泥和/或由此制成的骨水泥。
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公开(公告)号：US09180416B2
公开(公告)日：2015-11-10
申请号：US13474611
申请日：2012-05-17
申请人： Christopher U. Phan , Andrew Kohm
发明人： Christopher U. Phan , Andrew Kohm
CPC分类号： A61B17/8833 , A61B17/8805 , A61B17/8822 , A61B17/8827 , A61B2017/8838 , A61L24/0094 , B01F3/1214 , B01F11/0071 , B01F13/0023 , B01F15/00155 , B01F15/0247 , B01F15/0258 , B01F2003/1257 , B01F2215/0029
摘要： A system for use in combining two part preparations, such as bone cement, can include a chamber for intermixing liquid and powder components, a container, a vacuum channel, and a filter. The mixing chamber can be configured to hold a non-liquid, polymer powder component of a bone cement. The container can be configured to hold a liquid component of the bone cement. The vacuum channel can direct a partial vacuum to draw the liquid component from the container into the non-liquid component in the mixing chamber to intermix the components and to thereby provide a settable bone cement.
摘要翻译： 用于组合诸如骨水泥的两部分制剂的系统可以包括用于混合液体和粉末组分的腔室，容器，真空通道和过滤器。 混合室可以构造成容纳骨水泥的非液体聚合物粉末组分。 容器可以构造成容纳骨粘固剂的液体组分。 真空通道可以引导部分真空将液体组分从容器中抽出到混合室中的非液体组分中以混合组分，从而提供可固化的骨粘固剂。
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10.发明授权公开(公告)号：US09061051B2
公开(公告)日：2015-06-23
申请号：US13707995
申请日：2012-12-07
CPC分类号： A61K31/80 , A61K9/0024 , A61L24/0094 , C08L83/04 , C08L75/04
摘要： The present invention relates to a biocompatible polymer composition, suitable for in vivo vessel repair, comprising a matrix pre-polymer, a filler and a curing agent, wherein said composition wherein said biocompatible polymer composition is curable in the presence of a curing catalyst at 37° C. to form a cured material with an elongation until rupture of at least 5% and an elastic modulus of at least 1 MPa.
摘要翻译： 本发明涉及适用于体内容器修复的生物相容性聚合物组合物，其包含基质预聚物，填料和固化剂，其中所述组合物，其中所述生物相容性聚合物组合物在37℃的固化催化剂存在下可固化 以形成具有至少5％的断裂和至少1MPa的弹性模量的伸长率的固化材料。
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