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公开(公告)号：US20070178573A1
公开(公告)日：2007-08-02
申请号：US11361029
申请日：2006-02-23
申请人： Graham Cheetham , Kieron Brown , Sarah Vial , Neesha Dedi
发明人： Graham Cheetham , Kieron Brown , Sarah Vial , Neesha Dedi
CPC分类号： C12N9/1205 , C07K2299/00 , C07K2319/00
摘要： The invention relates to molecules or molecular complexes which comprise binding pockets of TAK1 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising TAK1. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the TAK1 or TAK1-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to TAK1 or homologues thereof.
摘要翻译： 本发明涉及包含TAK1或其结构同源物的结合口袋的分子或分子复合物。 本发明涉及可结晶组合物和包含TAK1的晶体。 本发明还涉及一种数据存储介质，其编码有分子和分子复合物的结构坐标，其包含TAK1或TAK1样ATP结合口袋。 本发明还涉及包含这种数据存储材料的计算机。 计算机可以产生这种分子或分子复合物的三维结构或图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计与TAK1或其同系物结合的化合物（包括抑制性化合物）的方法。
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公开(公告)号：US20110171714A1
公开(公告)日：2011-07-14
申请号：US12986404
申请日：2011-01-07
申请人： Graham Cheetham , Kieron Brown , Sarah Vial , Neesha Dedi
发明人： Graham Cheetham , Kieron Brown , Sarah Vial , Neesha Dedi
CPC分类号： C12N9/1205 , C07K2299/00 , C07K2319/00
摘要： The invention relates to molecules or molecular complexes which comprise binding pockets of TAK1 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising TAK1. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the TAK1 or TAK1-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to TAK1 or homologues thereof.
摘要翻译： 本发明涉及包含TAK1或其结构同源物的结合口袋的分子或分子复合物。 本发明涉及可结晶组合物和包含TAK1的晶体。 本发明还涉及一种数据存储介质，其编码有分子和分子复合物的结构坐标，其包含TAK1或TAK1样ATP结合口袋。 本发明还涉及包含这种数据存储材料的计算机。 计算机可以产生这种分子或分子复合物的三维结构或图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计与TAK1或其同系物结合的化合物（包括抑制性化合物）的方法。
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3.发明申请Crystal structure of interleukin-2 tyrosine kinase (ITK) and binding pockets thereof 审中-公开白细胞介素-2酪氨酸激酶（ITK）的晶体结构及其结合口袋公开(公告)号：US20060030016A1
公开(公告)日：2006-02-09
申请号：US11003787
申请日：2004-12-03
申请人： Graham Cheetham , Kieron Brown , Ronald Knegtel , Suzanne Renwick , Sarah Vial
发明人： Graham Cheetham , Kieron Brown , Ronald Knegtel , Suzanne Renwick , Sarah Vial
CPC分类号： C12N9/1205 , C07K2299/00 , G16B15/00
摘要： The invention relates to molecules or molecular complexes which comprise binding pockets of ITK or its structural homologues. The invention relates to crystallizable compositions and crystals comprising ITK. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the ITK or ITK-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ITK or homologues thereof.
摘要翻译： 本发明涉及包含ITK或其结构同系物的结合口袋的分子或分子复合物。 本发明涉及可结晶组合物和包含ITK的晶体。 本发明还涉及一种数据存储介质，其编码有包含ITK或ITK样ATP结合口袋的分子和分子复合物的结构坐标。 本发明还涉及包含这种数据存储材料的计算机。 计算机可以产生这种分子或分子复合物的三维结构或图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计结合ITK或其同系物的化合物（包括抑制性化合物）的方法。
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公开(公告)号：US20050143402A1
公开(公告)日：2005-06-30
申请号：US10979375
申请日：2004-11-01
申请人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce Coll , Suzanne Renwick , Peter Weber
发明人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce Coll , Suzanne Renwick , Peter Weber
IPC分类号： C12N9/12 , G06F19/00 , A61K31/517 , G01N33/48 , G01N33/50
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
摘要翻译： 本发明提供包含Aurora-2或其同系物的结合口袋的结晶分子或分子复合物。 本发明还提供了包含Aurora-2的晶体。 本发明还涉及包含用Aurora-2结合口袋的结构座标编码的数据存储介质的计算机，以及使用计算机评价化合物结合分子或分子复合物的能力的方法。 本发明还提供了使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明提供了使用结构坐标筛选和设计结合Aurora-2或其同系物的化合物（包括抑制性化合物）的方法。
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公开(公告)号：US08124392B2
公开(公告)日：2012-02-28
申请号：US12890826
申请日：2010-09-27
申请人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
发明人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
摘要翻译： 本发明提供包含Aurora-2或其同系物的结合口袋的结晶分子或分子复合物。 本发明还提供了包含Aurora-2的晶体。 本发明还涉及包含用Aurora-2结合口袋的结构座标编码的数据存储介质的计算机，以及使用计算机评价化合物结合分子或分子复合物的能力的方法。 本发明还提供了使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明提供了使用结构坐标筛选和设计结合Aurora-2或其同系物的化合物（包括抑制性化合物）的方法。
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公开(公告)号：US4152222A
公开(公告)日：1979-05-01
申请号：US827008
申请日：1977-08-23
申请人： Peter G. Sheasby , Graham Cheetham
发明人： Peter G. Sheasby , Graham Cheetham
摘要： Anodized aluminium having an anodic oxide film of at least 3 microns thickness is colored by electrolytically depositing inorganic pigment from metallic salt solutions, particularly nickel, cobalt, tin and copper salts and mixtures. The pigment deposits are characterized by outer ends of an average size in excess of 260 A lying at a distance of 500 - 3000 A from the aluminium/aluminium oxide interface.In a preferred method of production the anodic oxide coating is formed under conventional anodizing conditions in a sulphuric acid-based electrolyte. The anodized aluminium is then treated in phosphoric acid at a voltage of 8 - 50 volts to enlarge the pores to above 260 A in a region at the base of the pores adjacent the barrier layer. The pigment is then deposited in the pores to the specified depth and interesting new color shades are obtained as a result of optical interference due to the presence of the large size shallow inorganic pigment deposits.
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公开(公告)号：US20110104782A1
公开(公告)日：2011-05-05
申请号：US12890826
申请日：2010-09-27
申请人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
发明人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
摘要翻译： 本发明提供包含Aurora-2或其同系物的结合口袋的结晶分子或分子复合物。 本发明还提供了包含Aurora-2的晶体。 本发明还涉及包含用Aurora-2结合口袋的结构座标编码的数据存储介质的计算机，以及使用计算机评价化合物结合分子或分子复合物的能力的方法。 本发明还提供了使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明提供了使用结构坐标筛选和设计结合Aurora-2或其同系物的化合物（包括抑制性化合物）的方法。
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公开(公告)号：US07809541B2
公开(公告)日：2010-10-05
申请号：US12070054
申请日：2008-02-13
申请人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
发明人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
摘要翻译： 本发明提供包含Aurora-2或其同系物的结合口袋的结晶分子或分子复合物。 本发明还提供了包含Aurora-2的晶体。 本发明还涉及包含用Aurora-2结合口袋的结构座标编码的数据存储介质的计算机，以及使用计算机评价化合物结合分子或分子复合物的能力的方法。 本发明还提供了使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明提供了使用结构坐标筛选和设计结合Aurora-2或其同系物的化合物（包括抑制性化合物）的方法。
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公开(公告)号：US20090287422A1
公开(公告)日：2009-11-19
申请号：US12070054
申请日：2008-02-13
申请人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
发明人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
摘要翻译： 本发明提供包含Aurora-2或其同系物的结合口袋的结晶分子或分子复合物。 本发明还提供了包含Aurora-2的晶体。 本发明还涉及包含用Aurora-2结合口袋的结构座标编码的数据存储介质的计算机，以及使用计算机评价化合物结合分子或分子复合物的能力的方法。 本发明还提供了使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明提供了使用结构坐标筛选和设计结合Aurora-2或其同系物的化合物（包括抑制性化合物）的方法。
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10.发明授权Aluminium articles having anodic oxide coatings and methods of coloring them by means of optical interference effects 失效具有阳极氧化物涂层的铝制品和通过光学干涉效应使它们着色的方法
公开(公告)号：US4310586A
公开(公告)日：1982-01-12
申请号：US140447
申请日：1980-04-17
CPC分类号： C25D11/22 , C25D11/12 , Y10S205/917 , Y10T428/265
摘要： The invention provides aluminium articles having porous anodic oxide films colored by means of an optical interference effect. In FIG. 4, the article 10 carries a first anodic oxide film 12 with pores 14 enlarged at their inner ends 20 and containing deposits 22. The products may be made by growing a second anodic oxide film 26 underneath the deposits 22 which are preferably of acid-resistant material. X is at least 26 nm, Y is preferably at least 60 nm, Z is preferably 15 nm to 200 nm, (Y+Z) is preferably 75 nm to 600 nm, and W is preferably at least 15 nm.
摘要翻译： 本发明提供了具有通过光学干涉效应着色的多孔阳极氧化膜的铝制品。 在图 如图4所示，制品10带有第一阳极氧化膜12，孔14在其内端20处扩大并含有沉积物22.产物可以通过在沉积物22的下面生长第二阳极氧化膜26制成，优选地具有耐酸性 材料。 X为26nm以上，Y优选为60nm以上，Z优选为15nm〜200nm，（Y + Z）优选为75nm〜600nm，W优选为15nm以上。
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