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公开(公告)号：US20070178573A1
公开(公告)日：2007-08-02
申请号：US11361029
申请日：2006-02-23
申请人： Graham Cheetham , Kieron Brown , Sarah Vial , Neesha Dedi
发明人： Graham Cheetham , Kieron Brown , Sarah Vial , Neesha Dedi
CPC分类号： C12N9/1205 , C07K2299/00 , C07K2319/00
摘要： The invention relates to molecules or molecular complexes which comprise binding pockets of TAK1 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising TAK1. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the TAK1 or TAK1-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to TAK1 or homologues thereof.
摘要翻译： 本发明涉及包含TAK1或其结构同源物的结合口袋的分子或分子复合物。 本发明涉及可结晶组合物和包含TAK1的晶体。 本发明还涉及一种数据存储介质，其编码有分子和分子复合物的结构坐标，其包含TAK1或TAK1样ATP结合口袋。 本发明还涉及包含这种数据存储材料的计算机。 计算机可以产生这种分子或分子复合物的三维结构或图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计与TAK1或其同系物结合的化合物（包括抑制性化合物）的方法。
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公开(公告)号：US20110171714A1
公开(公告)日：2011-07-14
申请号：US12986404
申请日：2011-01-07
申请人： Graham Cheetham , Kieron Brown , Sarah Vial , Neesha Dedi
发明人： Graham Cheetham , Kieron Brown , Sarah Vial , Neesha Dedi
CPC分类号： C12N9/1205 , C07K2299/00 , C07K2319/00
摘要： The invention relates to molecules or molecular complexes which comprise binding pockets of TAK1 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising TAK1. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the TAK1 or TAK1-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to TAK1 or homologues thereof.
摘要翻译： 本发明涉及包含TAK1或其结构同源物的结合口袋的分子或分子复合物。 本发明涉及可结晶组合物和包含TAK1的晶体。 本发明还涉及一种数据存储介质，其编码有分子和分子复合物的结构坐标，其包含TAK1或TAK1样ATP结合口袋。 本发明还涉及包含这种数据存储材料的计算机。 计算机可以产生这种分子或分子复合物的三维结构或图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计与TAK1或其同系物结合的化合物（包括抑制性化合物）的方法。
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3.发明申请Crystal structure of interleukin-2 tyrosine kinase (ITK) and binding pockets thereof 审中-公开白细胞介素-2酪氨酸激酶（ITK）的晶体结构及其结合口袋公开(公告)号：US20060030016A1
公开(公告)日：2006-02-09
申请号：US11003787
申请日：2004-12-03
申请人： Graham Cheetham , Kieron Brown , Ronald Knegtel , Suzanne Renwick , Sarah Vial
发明人： Graham Cheetham , Kieron Brown , Ronald Knegtel , Suzanne Renwick , Sarah Vial
CPC分类号： C12N9/1205 , C07K2299/00 , G16B15/00
摘要： The invention relates to molecules or molecular complexes which comprise binding pockets of ITK or its structural homologues. The invention relates to crystallizable compositions and crystals comprising ITK. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the ITK or ITK-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ITK or homologues thereof.
摘要翻译： 本发明涉及包含ITK或其结构同系物的结合口袋的分子或分子复合物。 本发明涉及可结晶组合物和包含ITK的晶体。 本发明还涉及一种数据存储介质，其编码有包含ITK或ITK样ATP结合口袋的分子和分子复合物的结构坐标。 本发明还涉及包含这种数据存储材料的计算机。 计算机可以产生这种分子或分子复合物的三维结构或图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计结合ITK或其同系物的化合物（包括抑制性化合物）的方法。
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4.发明授权Crystal structure of polo-like kinase 3 (PLK3) and binding pockets thereof 失效polo样激酶3（PLK3）的结构结构及其结合口袋公开(公告)号：US07700340B2
公开(公告)日：2010-04-20
申请号：US11818698
申请日：2007-06-14
IPC分类号： C12N9/12
CPC分类号： C12N9/1205 , C07K2299/00 , G06F19/16
摘要： The invention relates to molecules or molecular complexes, which comprise binding pockets of PLK3 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising PLK3. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the PLK3 or PLK3-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for, identify and design compounds, including inhibitory compounds that bind to PLK3 or homologues thereof.
摘要翻译： 本发明涉及分子或分子复合物，其包含PLK3或其结构同系物的结合口袋。 本发明涉及可结晶组合物和包含PLK3的晶体。 本发明还涉及一种用分子和分子复合物的结构坐标编码的数据存储介质，其包含PLK3或类似PLK3的ATP结合口袋。 本发明还涉及包含这种数据存储材料的计算机。 计算机可以产生这种分子或分子复合物的三维结构或图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选，鉴定和设计化合物的方法，包括结合PLK3或其同系物的抑制性化合物。
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5.发明申请Crystal structure of polo-like kinase 3 (PLK3) and binding pockets thereof 失效polo样激酶3（PLK3）的结构结构及其结合口袋公开(公告)号：US20080293579A1
公开(公告)日：2008-11-27
申请号：US11818698
申请日：2007-06-14
CPC分类号： C12N9/1205 , C07K2299/00 , G06F19/16
摘要： The invention relates to molecules or molecular complexes, which comprise binding pockets of PLK3 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising PLK3. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the PLK3 or PLK3-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for, identify and design compounds, including inhibitory compounds that bind to PLK3 or homologues thereof.
摘要翻译： 本发明涉及分子或分子复合物，其包含PLK3或其结构同系物的结合口袋。 本发明涉及可结晶组合物和包含PLK3的晶体。 本发明还涉及一种用分子和分子复合物的结构坐标编码的数据存储介质，其包含PLK3或类似PLK3的ATP结合口袋。 本发明还涉及包含这种数据存储材料的计算机。 计算机可以产生这种分子或分子复合物的三维结构或图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选，鉴定和设计化合物的方法，包括结合PLK3或其同系物的抑制性化合物。
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