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公开(公告)号：US20080220438A1
公开(公告)日：2008-09-11
申请号：US12109615
申请日：2008-04-25
申请人： Gregg B. Morin , Serge Lichtsteiner , Alain Philippe Vasserot , Robert Adams , William H. Andrews
发明人： Gregg B. Morin , Serge Lichtsteiner , Alain Philippe Vasserot , Robert Adams , William H. Andrews
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again in hyperplastic diseases, including many cancers. This disclosure provides regulatory elements that promote transcription in cells that express telomerase reverse transcriptase (TERT). The disclosure also provides systems using TERT promoter sequences for identifying compounds that can be used to modulate telomerase expression
摘要翻译： 端粒酶逆转录酶是负责维持端粒长度和增加祖细胞复制能力的端粒酶复合物的一部分。 端粒酶活性在成熟分化细胞中被关闭，但在包括许多癌症在内的增生性疾病中又重新开始。 本公开提供了在表达端粒酶逆转录酶（TERT）的细胞中促进转录的调节元件。 本公开还提供了使用TERT启动子序列鉴定可用于调节端粒酶表达的化合物的系统
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公开(公告)号：US07378244B2
公开(公告)日：2008-05-27
申请号：US11411604
申请日：2006-04-25
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again in hyperplastic diseases, including many cancers. This disclosure provides regulatory elements that promote transcription in cells that express telomerase reverse transcriptase (TERT). The disclosure also provides systems using TERT promoter sequences for identifying compounds that can be used to modulate telomerase expression.
摘要翻译： 端粒酶逆转录酶是负责维持端粒长度和增加祖细胞复制能力的端粒酶复合物的一部分。 端粒酶活性在成熟分化细胞中被关闭，但在包括许多癌症在内的增生性疾病中又重新开始。 本公开提供了在表达端粒酶逆转录酶（TERT）的细胞中促进转录的调节元件。 本公开还提供了使用TERT启动子序列鉴定可用于调节端粒酶表达的化合物的系统。
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公开(公告)号：US20060281106A1
公开(公告)日：2006-12-14
申请号：US11411604
申请日：2006-04-25
申请人： William Andrews , Gregg Morin , Serge Lichtsteiner , Alain Vasserot , Robert Adams , Lisa Cardoza , Jane Lebkowski
发明人： William Andrews , Gregg Morin , Serge Lichtsteiner , Alain Vasserot , Robert Adams , Lisa Cardoza , Jane Lebkowski
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again in hyperplastic diseases, including many cancers. This disclosure provides regulatory elements that promote transcription in cells that express telomerase reverse transcriptase (TERT). The disclosure also provides systems using TERT promoter sequences for identifying compounds that can be used to modulate telomerase expression
摘要翻译： 端粒酶逆转录酶是负责维持端粒长度和增加祖细胞复制能力的端粒酶复合物的一部分。 端粒酶活性在成熟分化细胞中被关闭，但在包括许多癌症在内的增生性疾病中又重新开始。 本公开提供了在表达端粒酶逆转录酶（TERT）的细胞中促进转录的调节元件。 本公开还提供了使用TERT启动子序列鉴定可用于调节端粒酶表达的化合物的系统
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4.发明申请公开(公告)号：US20060166254A1
公开(公告)日：2006-07-27
申请号：US11374817
申请日：2006-03-13
CPC分类号： C12N9/1241 , A61K39/00 , C12Y207/07049 , Y10S435/935
摘要： This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.
摘要翻译： 本发明提供了纯化的端粒酶及其纯化方法。 该方法包括使用几个连续的步骤，包括使用结合带负电荷的分子的基质，结合带正电荷的分子的基质，中间选择性基质，基于其大小，形状或浮力密度分离分子的方法， 并通过亲和纯化。
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5.发明申请Producing telomerase activators and inhibitors by screening with purified telomerase 失效通过用纯化的端粒酶筛选生产端粒酶激活剂和抑制剂公开(公告)号：US20050089883A1
公开(公告)日：2005-04-28
申请号：US10811033
申请日：2004-03-26
CPC分类号： C12N9/1241 , A61K39/00 , C12Y207/07049 , Y10S435/935
摘要： This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.
摘要翻译： 本发明提供了纯化的端粒酶及其纯化方法。 该方法包括使用几个连续的步骤，包括使用结合带负电荷的分子的基质，结合带正电荷的分子的基质，中间选择性基质，基于其大小，形状或浮力密度分离分子的方法， 并通过亲和纯化。
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