公开(公告)号：US08227766B2

公开(公告)日：2012-07-24

申请号：US12464855

申请日：2009-05-12

申请人： Gregg J. Chapman

发明人： Gregg J. Chapman

IPC分类号： G01N21/64

CPC分类号： G01J1/02 ,  A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  G01J1/0219 ,  G01J1/0228 ,  G01J1/0233 ,  G01J1/04 ,  G01J1/0411 ,  G01J1/58 ,  G01N21/645 ,  G01N2201/0221

摘要： A hand-held probe for intra-operative detection of fluorescence labeled compounds includes a housing comprising a handle and a columnar portion, and a power source within the housing. A light emission source proximate the columnar portion of the housing is configured to fluoresce at least one of predetermined compounds and predetermined antibodies. An excitation switch proximate the handle selectably activates the light emission source. A detector receives fluorescent light emissions directed toward the columnar portion from at least one of the compounds and antibodies and convert the fluorescent light emissions to a corresponding emission electrical signal. A controller within the housing receives the emission electrical signal from the detector and converts the emission electrical signal to a corresponding data signal. Finally, a data port within the housing receives the data signal from the controller, converts the data signal to a corresponding output signal, and transmits the output signal.

摘要翻译： 用于手术中检测荧光标记化合物的手持探针包括壳体，其包括手柄和柱状部分，以及壳体内的动力源。 靠近壳体的柱状部分的发光源被配置为使预定化合物和预定抗体中的至少一种发荧光。 靠近手柄的激励开关可选择地激活发光源。 检测器从至少一种化合物和抗体接收朝向柱状部分的荧光发射，并将荧光发射转换成相应的发射电信号。 壳体内的控制器接收来自检测器的发射电信号，并将发射电信号转换成相应的数据信号。 最后，外壳内的数据端口接收来自控制器的数据信号，将数据信号转换为相应的输出信号，并发送输出信号。

公开(公告)号：US20220082708A1

公开(公告)日：2022-03-17

申请号：US17148724

申请日：2021-01-14

申请人： Gregg J. Chapman

发明人： Gregg J. Chapman

IPC分类号： G01T1/16 ,  G01T1/24 ,  G01T1/202 ,  G01D5/48

摘要： A hybrid collimated probe incorporates two detectors consisting of a scintillating crystal or semiconductor material, such as Cadmium-Zinc-Telluride (CZT). The count rate measured on the rear detector is corrected for the shielding effect of the front detector before the count rate ratio is calculated. This is done by multiplying the rear detector count rate by a factor pre-determined from the thickness and density of the front detector for a specific radionuclide energy. The count rate ratio also must be corrected for the presence of background radiation at the target site. This is done by taking a 3 second average of the count rate over tissue that does not contain a radiotracer sequestered at the site of pathology, but in adjacent tissue that is uniformly perfused by a lower level concentration of the radiotracer circulating in the blood pool background.

公开(公告)号：US11562454B2

公开(公告)日：2023-01-24

申请号：US17148724

申请日：2021-01-14

申请人： Gregg J. Chapman

发明人： Gregg J. Chapman

IPC分类号： G06Q50/26 ,  G06F21/60 ,  G06F21/62 ,  G06F9/54 ,  G06Q50/00 ,  G06N5/04 ,  G09B19/00 ,  G06N20/00 ,  A61B6/00 ,  G01D5/48 ,  G01T1/16 ,  G01T1/202 ,  G01T1/24 ,  H04L67/53 ,  H04L67/50 ,  G06Q10/10

摘要： A hybrid collimated probe incorporates two detectors consisting of a scintillating crystal or semiconductor material, such as Cadmium-Zinc-Telluride (CZT). The count rate measured on the rear detector is corrected for the shielding effect of the front detector before the count rate ratio is calculated. This is done by multiplying the rear detector count rate by a factor pre-determined from the thickness and density of the front detector for a specific radionuclide energy. The count rate ratio also must be corrected for the presence of background radiation at the target site. This is done by taking a 3 second average of the count rate over tissue that does not contain a radiotracer sequestered at the site of pathology, but in adjacent tissue that is uniformly perfused by a lower level concentration of the radiotracer circulating in the blood pool background.

公开(公告)号：US20210219928A1

公开(公告)日：2021-07-22

申请号：US17148716

申请日：2021-01-14

申请人： Gregg J. Chapman

发明人： Gregg J. Chapman

IPC分类号： A61B6/00 ,  G01T1/161 ,  G01T7/00

摘要： The necessary detector configuration and mathematical algorithms to implement a lateral (side-viewing) field of view in a gamma detection probe designed for laparoscopic use is disclosed. For this application, the diameter of the probe is limited to 12 mm. A hybrid collimation design, using a combination of both electronic collimation and metallic shielding, allows the probe to detect gamma emissions form 15 KeV-1.0 MeV. In the lower energy range, the 1.52 mm tungsten shielding is sufficient to collimate the primary detector. Two additional detectors are used to provide electronic collimation and depth detection. The upper energy limit of 1.0 MeV is imposed to exclude the possibility of electron-positron pair production which occurs at energies of 1.022 MeV and greater.

公开(公告)号：US20090283698A1

公开(公告)日：2009-11-19

申请号：US12464855

申请日：2009-05-12

申请人： Gregg J. Chapman

发明人： Gregg J. Chapman

IPC分类号： G01J1/58

CPC分类号： G01J1/02 ,  A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  G01J1/0219 ,  G01J1/0228 ,  G01J1/0233 ,  G01J1/04 ,  G01J1/0411 ,  G01J1/58 ,  G01N21/645 ,  G01N2201/0221

摘要： A hand-held probe for intra-operative detection of fluorescence labeled compounds includes a housing comprising a handle and a columnar portion, and a power source within the housing. A light emission source proximate the columnar portion of the housing is configured to fluoresce at least one of predetermined compounds and predetermined antibodies. An excitation switch proximate the handle selectably activates the light emission source. A detector receives fluorescent light emissions directed toward the columnar portion from at least one of the compounds and antibodies and convert the fluorescent light emissions to a corresponding emission electrical signal. A controller within the housing receives the emission electrical signal from the detector and converts the emission electrical signal to a corresponding data signal. Finally, a data port within the housing receives the data signal from the controller, converts the data signal to a corresponding output signal, and transmits the output signal.

摘要翻译： 用于手术中检测荧光标记化合物的手持探针包括壳体，其包括手柄和柱状部分，以及壳体内的动力源。 靠近壳体的柱状部分的发光源被配置为使预定化合物和预定抗体中的至少一种发荧光。 靠近手柄的激励开关可选择地激活发光源。 检测器从至少一种化合物和抗体接收朝向柱状部分的荧光发射，并将荧光发射转换成相应的发射电信号。 壳体内的控制器接收来自检测器的发射电信号，并将发射电信号转换成相应的数据信号。 最后，外壳内的数据端口接收来自控制器的数据信号，将数据信号转换为相应的输出信号，并发送输出信号。