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    Method for the detection of Fusarium graminearum
    3.
    发明授权
    Method for the detection of Fusarium graminearum 失效
    检测禾谷镰刀菌的方法

    公开(公告)号：US07919243B2

    公开(公告)日：2011-04-05

    申请号：US11570226

    申请日：2005-07-14

    申请人： Robert Mach ,  Andreas Farnleitner ,  Georg Reischer

    发明人： Robert Mach ,  Andreas Farnleitner ,  Georg Reischer

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12Q1/6895

    摘要： A method for the detection of Fusarium graminearum (Gibberella zeae) comprising the steps: providing a sample containing a nucleic acid, contacting said sample with at least one forward primer and at least one reverse primer, wherein the at least one reverse primer hybridises within the β-tubulin nucleic acid sequence of Fusarium graminearum (Gibberella zeae) and comprises the nucleic acid sequence 5′-R1TTTTCGTX1GX2AGT-3′ (SEQ ID NO 1), wherein R1 comprises at least one nucleic acid residue of the β-tubulin nucleic acid sequence located upstream of the hybridisation site of the nucleic acid sequence SEQ ID NO 1 and subsequent to the nucleic acid sequence SEQ ID NO 1, X1 is guanine, adenine or inosine, X2 is cytosine, adenine or inosine, and wherein the at least one forward primer hybridises upstream of the hybridisation site of a nucleic acid sequence complementary to the at least one reverse primer, subjecting the sample contacted with the at least one forward primer and the at least one reverse primer to a nucleic acid amplification technique, and optionally determining the presence of Fusarium graminearum (Gibberella zeae) in a sample by detecting a nucleic acid amplification product.

    摘要翻译： 一种用于检测禾谷镰刀菌（玉米赤霉）的方法，包括以下步骤：提供含有核酸的样品，使所述样品与至少一个正向引物和至少一个反向引物接触，其中所述至少一个反向引物与 禾谷镰刀菌（Gibberella zeae）的微管蛋白核酸序列，其包含核酸序列5'-R1TTTTCGTX1GX2AGT-3'（SEQ ID NO 1），其中R 1包含至少一个β-微管蛋白核酸的核酸残基 酸序列位于核酸序列SEQ ID NO 1的杂交位点的上游，并且在核酸序列SEQ ID NO 1之后，X1是鸟嘌呤，腺嘌呤或肌苷，X2是胞嘧啶，腺嘌呤或肌苷，并且其中至少 一个正向引物杂交与至少一个反向引物互补的核酸序列的杂交位点的上游，对与至少一个正向引物接触的样品和t 他至少有一个与核酸扩增技术有关的反向引物，并且通过检测核酸扩增产物任选地测定样品中禾谷镰刀菌（Gibarerella zeae）的存在。

    METHOD FOR THE PRODUCTION OF ERYTHRITOL
    4.
    发明申请
    METHOD FOR THE PRODUCTION OF ERYTHRITOL 审中-公开
    生产艾力霉素的方法

    公开(公告)号：US20130210099A1

    公开(公告)日：2013-08-15

    申请号：US13876722

    申请日：2011-09-28

    申请人： Astrid Mach-Aigner ,  Robert Mach

    发明人： Astrid Mach-Aigner ,  Robert Mach

    IPC分类号： C12P7/18

    CPC分类号： C12P7/18

    摘要： The invention relates to a method for the production of erythritol, in which erythrose is reduced to erythritol using a NADPH-specific enzyme, wherein the enzyme is an erythrose reductase which was isolated from the group of saprophytes selected from the strains of Hypocrea, Gibberella, Aspergillus and Penicillium. Hereby it is possible to produce erythritol in high yields.

    摘要翻译： 本发明涉及一种生产赤藓糖醇的方法，其中使用NADPH特异性酶将赤藓糖还原成赤藓糖醇，其中该酶是从选自Hypocrea，Gibberella， 曲霉菌和青霉菌。 由此可以高产率生产赤藓糖醇。

    Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging
    5.
    发明授权
    Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging 有权
    放射性标记的苯甲酰胺类似物，其合成和用于诊断成像

    公开(公告)号：US07947838B2

    公开(公告)日：2011-05-24

    申请号：US12643175

    申请日：2009-12-21

    申请人： Robert Mach ,  Zhude Tu

    发明人： Robert Mach ,  Zhude Tu

    IPC分类号： C07D451/00 ,  C07D451/14

    CPC分类号： A61K31/47 ,  A61K31/495 ,  A61K51/04 ,  A61K51/0497 ,  C07C323/41 ,  C07D217/04 ,  C07D257/02 ,  C07D295/13

    摘要： Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

    摘要翻译： 公开了选择性结合Sigma-2受体的氟烷氧基苯甲酰胺化合物。 当用18F标记时，这些化合物可以用作通过正电子发射断层扫描（PET）成像肿瘤的放射性示踪剂。 此外，当用123I标记时，这些化合物可以用作通过单光子发射计算机断层摄影（SPECT）成像肿瘤的放射性示踪剂。 还公开了这些化合物的合成方法。

    RADIOLABELLED BENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING
    6.
    发明申请
    RADIOLABELLED BENZAMIDE ANALOGUES, THEIR SYNTHESIS AND USE IN DIAGNOSTIC IMAGING 有权
    无定形苯扎酰胺类似物，其合成和用于诊断成像

    公开(公告)号：US20100150836A1

    公开(公告)日：2010-06-17

    申请号：US12643175

    申请日：2009-12-21

    申请人： Robert Mach ,  Zhude Tu

    发明人： Robert Mach ,  Zhude Tu

    IPC分类号： A61K51/04 ,  A61P35/00

    CPC分类号： A61K31/47 ,  A61K31/495 ,  A61K51/04 ,  A61K51/0497 ,  C07C323/41 ,  C07D217/04 ,  C07D257/02 ,  C07D295/13

    摘要： Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

    摘要翻译： 公开了选择性结合Sigma-2受体的氟烷氧基苯甲酰胺化合物。 当用18F标记时，这些化合物可以用作通过正电子发射断层扫描（PET）成像肿瘤的放射性示踪剂。 此外，当用123I标记时，这些化合物可以用作通过单光子发射计算机断层摄影（SPECT）成像肿瘤的放射性示踪剂。 还公开了这些化合物的合成方法。

    DETECTION OF CANCER CELLS IN VITRO USING SIGMA-2 RECEPTOR LIGANDS AS RADIOTRACERS
    7.
    发明申请
    DETECTION OF CANCER CELLS IN VITRO USING SIGMA-2 RECEPTOR LIGANDS AS RADIOTRACERS 有权
    使用SIGMA-2受体配体作为放射线检测体外检测癌细胞

    公开(公告)号：US20100028936A1

    公开(公告)日：2010-02-04

    申请号：US12550220

    申请日：2009-08-28

    申请人： Robert Mach ,  Michael J. Welch ,  Douglas J. Rowland ,  Zhude Tu

    发明人： Robert Mach ,  Michael J. Welch ,  Douglas J. Rowland ,  Zhude Tu

    IPC分类号： C12Q1/02

    CPC分类号： C07D295/13 ,  A61K31/47 ,  A61K31/495 ,  A61K51/04 ,  A61K51/0497 ,  C07C323/41 ,  C07D217/04 ,  C07D257/02

    摘要： Methods for detection of cancer cells and for determining the proliferative status of cells in a tissue sample in vitro are disclosed. These methods comprise contacting a tissue sample with a radiolabeled compound or salt thereof of Formula wherein at least one of X, Y, and Z comprises a radioisotope, n is an integer from 2 to about 10; and each of A and A1 is a C1-C4 alkoxyl, a C1-C4 fluoroalkyl or a C1-C4 fluoroalkoxyl. The methods further comprise detecting the distribution of the radioisotope in the tissue sample, whereby a cell having a high density of the radioisotope compared to quiescent cells is diagnostic for a cancer cell.

    摘要翻译： 公开了用于检测癌细胞并用于测定体外组织样品中细胞增殖状态的方法。 这些方法包括使组织样品与其中X，Y和Z中的至少一个包含放射性同位素的放射性标记的化合物或其盐接触，n为2至约10的整数; A和A1各自为C1-C4烷氧基，C1-C4氟烷基或C1-C4氟烷氧基。 所述方法还包括检测组织样品中放射性同位素的分布，由此与静止细胞相比具有高密度放射性同位素的细胞是癌细胞的诊断。

    Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors
    8.
    发明授权
    Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors 有权
    用于成像实体瘤增殖状态的Sigma-2受体放射性示踪剂

    公开(公告)号：US07612206B2

    公开(公告)日：2009-11-03

    申请号：US12044952

    申请日：2008-03-08

    申请人： Robert Mach ,  Michael J. Welch ,  Douglas J. Rowland ,  Zhude Tu

    发明人： Robert Mach ,  Michael J. Welch ,  Douglas J. Rowland ,  Zhude Tu

    IPC分类号： C07D491/00 ,  A61K51/00 ,  A61M36/14

    CPC分类号： C07D295/13 ,  A61K31/47 ,  A61K31/495 ,  A61K51/04 ,  A61K51/0497 ,  C07C323/41 ,  C07D217/04 ,  C07D257/02

    摘要： Novel benzamide compounds of Formula (I), Formula (II), and Formula (III), salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mammal for the presence of a mammalian tumor therein comprises administering to the mammal a diagnostic imaging detectable effective amount of a benzamide compound having a structure illustrated in Formula (I), Formula (II) and Formula (III) and detecting binding of the compound to a tumor in the mammal. A method for diagnostic imaging of a mammalian tissue having cell surface sigma-2 receptors comprising administering to a mammal a diagnostic imaging amount of a compound having a structure illustrated in Formula (I) Formula (II) and Formula (III) and detecting an image of a tissue having an ample cells with sigma-2 receptors.

    摘要翻译： 式（I），式（II）和式（III）的新型苯甲酰胺化合物，其盐，水溶性盐，类似物和放射性标记的对应物作为用于成像实体瘤增殖状态的σ-2受体放射性示踪剂。 用于诊断哺乳动物存在哺乳动物肿瘤的方法包括给予哺乳动物诊断成像可检测的有效量的具有式（I），式（II）和式（III）所示结构的苯甲酰胺化合物和检测 化合物与哺乳动物肿瘤的结合。 一种用于具有细胞表面σ-2受体的哺乳动物组织的诊断成像的方法，包括向哺乳动物施用具有式（I）式（II）和式（III）所示结构的化合物的诊断成像量，并检测图像 的具有西格玛-2受体的大量细胞的组织。

    SIGMA-2 RECEPTOR RADIOTRACERS FOR IMAGING THE PROLIFERATIVE STATUS OF SOLID TUMORS
    10.
    发明申请
    SIGMA-2 RECEPTOR RADIOTRACERS FOR IMAGING THE PROLIFERATIVE STATUS OF SOLID TUMORS 有权
    用于成像固体肿瘤增生状态的SIGMA-2受体放射剂

    公开(公告)号：US20090041663A1

    公开(公告)日：2009-02-12

    申请号：US12044952

    申请日：2008-03-08

    申请人： Robert Mach

    发明人： Robert Mach

    IPC分类号： A61K51/04 ,  A61K101/00 ,  A61K101/02

    CPC分类号： C07D295/13 ,  A61K31/47 ,  A61K31/495 ,  A61K51/04 ,  A61K51/0497 ,  C07C323/41 ,  C07D217/04 ,  C07D257/02

    摘要： Novel benzamide compounds of Formula (I), Formula (II), and Formula (III), salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mammal for the presence of a mammalian tumor therein comprises administering to the mammal a diagnostic imaging detectable effective amount of a benzamide compound having a structure illustrated in Formula (I), Formula (II) and Formula (III) and detecting binding of the compound to a tumor in the mammal. A method for diagnostic imaging of a mammalian tissue having cell surface sigma-2 receptors comprising administering to a mammal a diagnostic imaging amount of a compound having a structure illustrated in Formula (I) Formula (II) and Formula (III) and detecting an image of a tissue having an ample cells with sigma-2 receptors.

    摘要翻译： 式（I），式（II）和式（III）的新型苯甲酰胺化合物，其盐，水溶性盐，类似物和放射性标记的对应物作为用于成像实体瘤增殖状态的σ-2受体放射性示踪剂。 用于诊断哺乳动物存在哺乳动物肿瘤的方法包括给予哺乳动物诊断成像可检测的有效量的具有式（I），式（II）和式（III）所示结构的苯甲酰胺化合物和检测 化合物与哺乳动物肿瘤的结合。 一种用于具有细胞表面σ-2受体的哺乳动物组织的诊断成像的方法，包括向哺乳动物施用具有式（I）式（II）和式（III）所示结构的化合物的诊断成像量，并检测图像 的具有西格玛-2受体的大量细胞的组织。