公开(公告)号：US20170037087A1

公开(公告)日：2017-02-09

申请号：US15304462

申请日：2015-04-15

Applicant: Griffith University

Inventor： Manisha Pandey ,  Michael Batzloff ,  Michael Good

IPC: C07K14/315 ,  C07K16/12 ,  A61K38/48 ,  C07K16/40 ,  A61K39/09 ,  A61K39/395

CPC classification number: C07K14/315 ,  A61K38/4873 ,  A61K39/092 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/1275 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  C12Y304/22

Abstract: A method and composition for eliciting an immune response to group A streptococcal bacteria in a mammal is provided, which includes administering to the mammal an M protein fragment, variant or derivative thereof and a SpyCEP protein or peptide fragment, or an antibody to the SpyCEP protein or fragment to facilitate restoring or enhancing neutrophil activity. Also provided is an immunodominant peptide fragment of SpyCEP.

Abstract translation: 提供了一种用于在哺乳动物中引起对A组链球菌细菌的免疫应答的方法和组合物，其包括向哺乳动物施用M蛋白片段，其变体或衍生物和SpyCEP蛋白或肽片段或对SpyCEP蛋白的抗体 或片段以促进中性粒细胞活性的恢复或增强。 还提供了SpyCEP的免疫显性肽片段。

公开(公告)号：US11406694B2

公开(公告)日：2022-08-09

申请号：US16333675

申请日：2016-10-24

Applicant: GRIFFITH UNIVERSITY

Inventor： Michael Good ,  Danielle Stanisic ,  Leanne Low

IPC: A61K39/002 ,  A61K39/018 ,  A61P33/06 ,  A61K31/65 ,  A61K39/015 ,  A61P33/02 ,  A01K67/027 ,  A61K31/435 ,  A61K31/7056 ,  A61K39/00

Abstract: Apicomplexan parasites or red blood cells infected with apicomplexan parasites are administered to an animal in combination with a delayed death agent that initially allows parasite replication but subsequently kills the apicomplexan parasites. This allows the elicitation of an immune response by the animal while preventing the parasites producing a serious infection of the animal. The apicomplexan parasites may be malaria or babesia parasites. The delayed death agent may be a tetracycline class antibiotic, a macrolide antibiotic or a lincosamide antibiotic.

公开(公告)号：US20190256562A1

公开(公告)日：2019-08-22

申请号：US16398598

申请日：2019-04-30

Applicant: Griffith University

Inventor： Manisha Pandey ,  Michael Batzloff ,  Michael Good

IPC: C07K14/315 ,  A61K38/48 ,  A61K39/395 ,  C07K16/40 ,  A61K39/09 ,  C07K16/12

Abstract: The invention relates to methods of eliciting an immune response to group A streptococcal bacteria in a mammal, the method including the step of administering to the mammal an effective amount of a composition comprising an isolated p145 peptide of SEQ ID NO: 56 and/or a p145 peptide variant having an amino acid sequence at least 90% identical to SEQ ID NO: 56, and an isolated SpyCEP peptide of SEQ ID NO: 18 and/or a SpyCEP peptide variant having an amino acid sequence at least 90% identical to SEQ ID NO: 18.

公开(公告)号：US10513544B2

公开(公告)日：2019-12-24

申请号：US16398598

申请日：2019-04-30

Applicant: Griffith University

Inventor： Manisha Pandey ,  Michael Batzloff ,  Michael Good

IPC: A61K39/09 ,  A61K39/395 ,  A61K38/48 ,  C07K14/315 ,  C07K16/12 ,  C07K16/40 ,  A61K39/00

Abstract: The invention relates to methods of eliciting an immune response to group A streptococcal bacteria in a mammal, the method including the step of administering to the mammal an effective amount of a composition comprising an isolated p145 peptide of SEQ ID NO: 56 and/or a p145 peptide variant having an amino acid sequence at least 90% identical to SEQ ID NO: 56, and an isolated SpyCEP peptide of SEQ ID NO: 18 and/or a SpyCEP peptide variant having an amino acid sequence at least 90% identical to SEQ ID NO: 18.

公开(公告)号：US10301362B2

公开(公告)日：2019-05-28

申请号：US15304462

申请日：2015-04-15

Applicant: Griffith University

Inventor： Manisha Pandey ,  Michael Batzloff ,  Michael Good

IPC: C07K14/315 ,  C07K16/12 ,  A61K39/09 ,  A61K38/48 ,  A61K39/395 ,  C07K16/40 ,  A61K39/00

Abstract: A method and composition for eliciting an immune response to group A streptococcal bacteria in a mammal is provided, which includes administering to the mammal an M protein fragment, variant or derivative thereof and a SpyCEP protein or peptide fragment, or an antibody to the SpyCEP protein or fragment to facilitate restoring or enhancing neutrophil activity. Also provided is an immunodominant peptide fragment of SpyCEP.