公开(公告)号：US20220185769A1

公开(公告)日：2022-06-16

申请号：US17440759

申请日：2020-03-18

申请人： Guang An Mojia Biotechnology Co., Ltd.

发明人： Man Kit LAU ,  Yan CHEN ,  Ansen CHIEW ,  Chengliang LU ,  Congming ZENG ,  Jinhuan SU ,  Weihua LU

IPC分类号： C07C235/12 ,  C07C227/08 ,  C07C231/02 ,  C12P13/06 ,  C12N9/88

摘要： Provided is a method for preparing β-alanine, the method comprising: preparing a β-alanine product from a reactant containing fumaric acid and aqueous ammonia in the presence of a catalyst, wherein the catalyst contains a catalyst composition containing aspartase and L-aspartic acid-α-decarboxylase, and adding fumaric acid during the reaction, wherein the total moles of the fumaric acid added is equal to the initial moles of the aqueous ammonia in the reactant minus the initial moles of the fumaric acid in the reactant. Also provided are methods for preparing a β-alanine salt (in particular calcium β-alanine, sodium β-alanine, and potassium β-alanine) and a pantothenate (in particular calcium pantothenate, sodium pantothenate, and potassium pantothenate).

公开(公告)号：US20220154240A1

公开(公告)日：2022-05-19

申请号：US17434418

申请日：2020-02-26

申请人： Guang An Mojia Biotechnology Co., Ltd.

发明人： Ansen CHIEW ,  Jinhuan SU ,  Congming ZENG ,  Tailong JIANG ,  Yan CHEN ,  Man Kit LAU

IPC分类号： C12P41/00 ,  C12P17/04

摘要： Disclosed is a method for resolving an optical isomer from a racemate by means of electrodialysis. Specifically, an electrodialysis technique is used in an enzymatic resolution process, mainly in the separation of products after enzymatic resolution. Taking a preparation process for D-pantolactone as an example, the key point is that D-pantoic acid and L-pantolactone are separated from an enzymatic resolution solution by means of an electrodialysis method, which replaces the existing organic solvent extraction method. The process method is simple and easy to operate, has a high yield of D-pantoic acid of a good purity, greatly reduces the usage amount of an organic solvent, reduces production costs and is environmentally friendly, such that the working environment of workers can be improved to a great extent, and the operation safety index is improved.

公开(公告)号：US20220195471A1

公开(公告)日：2022-06-23

申请号：US17606448

申请日：2020-04-23

申请人： Guang An Mojia Biotechnology Co., Ltd.

发明人： Man Kit LAU ,  Jinhuan SU ,  Ansen CHIEW ,  Yan CHEN ,  Congming ZENG

IPC分类号： C12P17/04 ,  C07D307/33 ,  B01D11/04

摘要： Provided is a method for resolving an optical isomer from a racemate by using supercritical fluid extraction technology. The method is mainly applied to the separation of a product obtained after enzymatic resolution. Taking a preparation process of D-pantolactone as an example, the key point is to separate D-pantolactone and L-pantolactone from an enzymatic resolution liquid by means of supercritical fluid extraction.