公开(公告)号：US20170333374A1

公开(公告)日：2017-11-23

申请号：US15508761

申请日：2013-07-05

申请人： Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Phamaceutical Factory ,  Guangzhou Institute of Respiratory Disease

发明人： Mao Chen ,  Shaoxuan Zhu ,  Ping Wan ,  Wei Wang ,  Wei Liao ,  Hairong Hu ,  Xianglin Fu ,  Jin Feng ,  Binge Huang ,  Lin Zhang ,  Nanshan Zhong ,  Jinping Zheng ,  Hongying Mo

IPC分类号： A61K31/198 ,  C07C323/58 ,  C07C319/28

CPC分类号： A61K31/198 ,  C07B2200/07 ,  C07C319/14 ,  C07C319/28 ,  C07C323/58

摘要： Disclosed are an S-(carboxymethyl)-cysteine pharmaceutical compound (I), and a preparation method and use thereof. Also disclosed are an S-(carboxymethyl)-D-cysteine ammonium salt monohydrate, and use thereof in preparation of medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases, in particular in preparation of expectorants. The compounds can reduce airway resistance and production of oxides in rat COPD models, increase the level of antioxidants, and alleviate damage caused by the oxides and inflammatory mediators to lungs.

公开(公告)号：US10251854B2

公开(公告)日：2019-04-09

申请号：US15508761

申请日：2013-07-05

申请人： Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory ,  Guangzhou Institute of Respiratory Disease

发明人： Mao Chen ,  Shaoxuan Zhu ,  Ping Wan ,  Wei Wang ,  Wei Liao ,  Hairong Hu ,  Xianglin Fu ,  Jin Feng ,  Binge Huang ,  Lin Zhang ,  Nanshan Zhong ,  Jinping Zheng ,  Hongying Mo

IPC分类号： A61K31/198 ,  C07C323/58 ,  C07C319/28 ,  C07C319/14

摘要： Disclosed are an S-(carboxymethyl)-cysteine pharmaceutical compound (I), and a preparation method and use thereof. Also disclosed are an S-(carboxymethyl)-D-cysteine ammonium salt monohydrate, and use thereof in preparation of medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases, in particular in preparation of expectorants. The compounds can reduce airway resistance and production of oxides in rat COPD models, increase the level of antioxidants, and alleviate damage caused by the oxides and inflammatory mediators to lungs.