公开(公告)号：US09879027B2

公开(公告)日：2018-01-30

申请号：US15494538

申请日：2017-04-23

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE

发明人： Kefang Lai ,  Xiaodong Liu ,  Bonian Zhong ,  Shan Zhong ,  Chuqin Huang

IPC分类号： A61K36/00 ,  C07D493/04 ,  A61K36/264 ,  A61K31/36

CPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264 ,  A61K2236/13 ,  A61K2236/33 ,  A61K2236/37 ,  A61K2236/39 ,  Y02P20/544

摘要： The invention discloses a method for extracting high-purity asarinin and use thereof. The method comprises: putting crude asarum powder in an SFE-CO2 device; under the conditions that an extraction kettle has a pressure of 30-40 Mpa and a temperature of 45-70° C., separating kettles I and II have a pressure of 5-10 Mpa, a temperature of 30-50° C. and the flow rate of CO2 is 35-60 L/h, extracting for 60-240 min to obtain total volatile oil of asarum; standing the total volatile oil of asarum for 24-72 h at a low temperature, and carrying out suction filtration under reduced pressure to obtain crude asarinin; and re-crystallizing the crude asarinin in absolute ethanol twice to obtain pure asarinin. It is found for the first time that asarinin has a good cough-relieving activity and thus can be used in preparing medicines for treating various types of coughs.

公开(公告)号：US09629869B2

公开(公告)日：2017-04-25

申请号：US15351512

申请日：2016-11-15

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE ,  STATE KEY LABORATORY OF RESPIRATORY DISEASE

发明人： Kefang Lai ,  Shan Zhong ,  Zhenyong Gan ,  Xiaodong Liu ,  Yichu Nie ,  Nanshan Zhong

IPC分类号： A61K36/00 ,  A61K31/715 ,  A61K36/79 ,  A23L29/30 ,  A23P10/00

CPC分类号： A61K31/715 ,  A23L5/00 ,  A23L29/30 ,  A23L33/125 ,  A23P10/00 ,  A23V2002/00 ,  A61K36/79 ,  A61K2236/15 ,  A61K2236/33

摘要： The present invention relates to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for treating coughing, and more specifically to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for preventing and relieving coughing and eliminating airway inflammation. Experiments demonstrate that the Fructus schisandrae total polysaccharides can remarkably reduce the coughing times of a guinea pig with increased cough sensitivity induced by cigarette smoke and an acute cough guinea pig induced by citric acid smoke, prolong the latent period of cough, and significantly reduce the airway inflammation of the guinea pig with increased cough susceptibility induced by cigarette smoke, so that the Fructus schisandrae total polysaccharides can be used for preparing drugs for preventing cough, relieving cough and eliminating airway inflammation.

公开(公告)号：US20170056431A1

公开(公告)日：2017-03-02

申请号：US15351512

申请日：2016-11-15

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE ,  STATE KEY LABORATORY OF RESPIRATORY DISEASE

发明人： Kefang Lai ,  Shan Zhong ,  Zhenyong Gan ,  Xiaodong Liu ,  Yichu Nie ,  Nanshan Zhong

IPC分类号： A61K31/715 ,  A23L29/30 ,  A23P10/00 ,  A61K36/79

CPC分类号： A61K31/715 ,  A23L5/00 ,  A23L29/30 ,  A23L33/125 ,  A23P10/00 ,  A23V2002/00 ,  A61K36/79 ,  A61K2236/15 ,  A61K2236/33

摘要： The present invention relates to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for treating coughing, and more specifically to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for preventing and relieving coughing and eliminating airway inflammation. Experiments demonstrate that the Fructus schisandrae total polysaccharides can remarkably reduce the coughing times of a guinea pig with increased cough sensitivity induced by cigarette smoke and an acute cough guinea pig induced by citric acid smoke, prolong the latent period of cough, and significantly reduce the airway inflammation of the guinea pig with increased cough susceptibility induced by cigarette smoke, so that the Fructus schisandrae total polysaccharides can be used for preparing drugs for preventing cough, relieving cough and eliminating airway inflammation.

摘要翻译： 本发明涉及五味子总多糖在制备用于治疗咳嗽的药物或营养品中的新应用，更具体地涉及五味子总多糖在制备用于预防和减轻咳嗽和消除气道炎症的药物或营养品中的新应用 。 实验表明，五味子总多糖可以显着降低豚鼠咳嗽时间，吸烟引起咳嗽敏感性增加，柠檬酸烟引起急性咳嗽豚鼠，延长咳嗽潜伏期，明显减少气道 香烟烟雾引起的咳嗽易感性增加的豚鼠发炎，使五味子总多糖可用于制备预防咳嗽，缓解咳嗽和消除呼吸道炎症的药物。

公开(公告)号：US20160339054A1

公开(公告)日：2016-11-24

申请号：US15110100

申请日：2015-03-25

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE

发明人： Kefang LAI ,  Xiaodong LIU ,  Bonian ZHONG ,  Shan ZHONG ,  Yichu NIE

IPC分类号： A61K31/715 ,  A61K36/268

CPC分类号： A61K31/715 ,  A61K36/268 ,  A61K2236/00 ,  A61K2236/30

摘要： The present invention discloses an Asarum total polysaccharide extract with antitussive activity, an extraction method thereof and an application in the preparation of a medicine for preventing and treating coughs. The present invention proves that the Asarum total polysaccharide extract has a significant effect of suppressing cough for the first time through a large number of pharmacodynamic tests, has the therapeutic effect approximate to codeine, has the effect of prolonging the cough latent period better than codeine, and also finds that the total Asarum polysaccharide extract has the effects of reducing the cough sensitivity and suppressing the airway inflammation for the first time, has excellent preventive and therapeutic effects on various types of coughs, and can be used for preparing the medicines for preventing and treating cough-related diseases.

摘要翻译： 本发明公开了具有镇咳活性的Asarum全多糖提取物及其提取方法以及用于预防和治疗咳嗽药物的应用。 本发明证明，Asarum全多糖提取物通过大量药效学试验首次具有抑制咳嗽的显着作用，具有接近可待因的治疗作用，具有延长咳嗽潜伏期比可待因更好的效果， 并且发现总Asarum多糖提取物首次具有降低咳嗽敏感性和抑制气道炎症的作用，对各种咳嗽具有优异的预防和治疗效果，并且可用于制备预防和治疗药物， 治疗咳嗽相关疾病

公开(公告)号：US20180271896A1

公开(公告)日：2018-09-27

申请号：US15996504

申请日：2018-06-03

申请人： THE FIRST AFFILIATTED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE

发明人： Kefang LAI ,  Xiaodong LIU ,  Bonian ZHONG ,  Shan ZHONG ,  Yichu NIE

IPC分类号： A61K31/715 ,  A61K36/268

摘要： The present invention discloses an Asarum total polysaccharide extract with antitussive activity, an extraction method thereof and an application in the preparation of a medicine for preventing and treating coughs. The present invention proves that the Asarum total polysaccharide extract has a significant effect of suppressing cough for the first time through a large number of pharmacodynamic tests, has the therapeutic effect approximate to codeine, has the effect of prolonging the cough latent period better than codeine, and also finds that the total Asarum polysaccharide extract has the effects of reducing the cough sensitivity and suppressing the airway inflammation for the first time, has excellent preventive and therapeutic effects on various types of coughs, and can be used for preparing the medicines for preventing and treating cough-related diseases.

公开(公告)号：US10744152B2

公开(公告)日：2020-08-18

申请号：US15996504

申请日：2018-06-03

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE

发明人： Kefang Lai ,  Xiaodong Liu ,  Bonian Zhong ,  Shan Zhong ,  Yichu Nie

IPC分类号： A61K36/00 ,  A61K31/715 ,  A61K36/268

摘要： The present invention discloses an Asarum total polysaccharide extract with antitussive activity, an extraction method thereof and an application in the preparation of a medicine for preventing and treating coughs. The present invention proves that the Asarum total polysaccharide extract has a significant effect of suppressing cough for the first time through a large number of pharmacodynamic tests, has the therapeutic effect approximate to codeine, has the effect of prolonging the cough latent period better than codeine, and also finds that the total Asarum polysaccharide extract has the effects of reducing the cough sensitivity and suppressing the airway inflammation for the first time, has excellent preventive and therapeutic effects on various types of coughs, and can be used for preparing the medicines for preventing and treating cough-related diseases.

公开(公告)号：US10251854B2

公开(公告)日：2019-04-09

申请号：US15508761

申请日：2013-07-05

申请人： Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory ,  Guangzhou Institute of Respiratory Disease

发明人： Mao Chen ,  Shaoxuan Zhu ,  Ping Wan ,  Wei Wang ,  Wei Liao ,  Hairong Hu ,  Xianglin Fu ,  Jin Feng ,  Binge Huang ,  Lin Zhang ,  Nanshan Zhong ,  Jinping Zheng ,  Hongying Mo

IPC分类号： A61K31/198 ,  C07C323/58 ,  C07C319/28 ,  C07C319/14

摘要： Disclosed are an S-(carboxymethyl)-cysteine pharmaceutical compound (I), and a preparation method and use thereof. Also disclosed are an S-(carboxymethyl)-D-cysteine ammonium salt monohydrate, and use thereof in preparation of medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases, in particular in preparation of expectorants. The compounds can reduce airway resistance and production of oxides in rat COPD models, increase the level of antioxidants, and alleviate damage caused by the oxides and inflammatory mediators to lungs.

公开(公告)号：US20180305372A1

公开(公告)日：2018-10-25

申请号：US15694938

申请日：2017-09-04

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE

发明人： Kefang LAI ,  Xiaodong LIU ,  Bonian ZHONG ,  Shan ZHONG ,  Chuqin HUANG

IPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264

CPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264 ,  A61K2236/13 ,  A61K2236/33 ,  A61K2236/37 ,  A61K2236/39 ,  Y02P20/544

摘要： The invention discloses a use of asarinin in preparation of medicines for treating various coughs. The asarinin is used for preparing medicines for treating various coughs separately or in combination with other medicines. The asarinin can be extracted by an SFE-CO2 method. The asarinin and usable drug carriers or excipients are made into various formulations. And the formulations are granules, tablets, capsules, soft capsules, pills, dripping pills, ointments, syrups, injection, oral liquid, tinctures, sustained-releasing drugs, controlled release drugs or targeting preparations.

公开(公告)号：US20170333374A1

公开(公告)日：2017-11-23

申请号：US15508761

申请日：2013-07-05

申请人： Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Phamaceutical Factory ,  Guangzhou Institute of Respiratory Disease

发明人： Mao Chen ,  Shaoxuan Zhu ,  Ping Wan ,  Wei Wang ,  Wei Liao ,  Hairong Hu ,  Xianglin Fu ,  Jin Feng ,  Binge Huang ,  Lin Zhang ,  Nanshan Zhong ,  Jinping Zheng ,  Hongying Mo

IPC分类号： A61K31/198 ,  C07C323/58 ,  C07C319/28

CPC分类号： A61K31/198 ,  C07B2200/07 ,  C07C319/14 ,  C07C319/28 ,  C07C323/58

摘要： Disclosed are an S-(carboxymethyl)-cysteine pharmaceutical compound (I), and a preparation method and use thereof. Also disclosed are an S-(carboxymethyl)-D-cysteine ammonium salt monohydrate, and use thereof in preparation of medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases, in particular in preparation of expectorants. The compounds can reduce airway resistance and production of oxides in rat COPD models, increase the level of antioxidants, and alleviate damage caused by the oxides and inflammatory mediators to lungs.

公开(公告)号：US20170283428A1

公开(公告)日：2017-10-05

申请号：US15494538

申请日：2017-04-23

申请人： GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE

发明人： Kefang LAI ,  Xiaodong LIU ,  Bonian ZHONG ,  Shan ZHONG ,  Chuqin HUANG

IPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264

CPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264 ,  A61K2236/13 ,  A61K2236/33 ,  A61K2236/37 ,  A61K2236/39 ,  Y02P20/544

摘要： The invention discloses a method for extracting high-purity asarinin and use thereof. The method comprises: putting crude asarum powder in an SFE-CO2 device; under the conditions that an extraction kettle has a pressure of 30-40 Mpa and a temperature of 45-70° C., separating kettles I and II have a pressure of 5-10 Mpa, a temperature of 30-50° C. and the flow rate of CO2 is 35-60 L/h, extracting for 60-240 min to obtain total volatile oil of asarum; standing the total volatile oil of asarum for 24-72 h at a low temperature, and carrying out suction filtration under reduced pressure to obtain crude asarinin; and re-crystallizing the crude asarinin in absolute ethanol twice to obtain pure asarinin. It is found for the first time that asarinin has a good cough-relieving activity and thus can be used in preparing medicines for treating various types of coughs.