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    METHOD FOR CONTINUOUS PREPARATION OF HIGH BULK DENSITY METHIONINE CRYSTAL
    3.
    发明申请
    METHOD FOR CONTINUOUS PREPARATION OF HIGH BULK DENSITY METHIONINE CRYSTAL 审中-公开

    公开(公告)号：US20180043281A1

    公开(公告)日：2018-02-15

    申请号：US15549833

    申请日：2015-12-23

    Applicant: Shandong Nhu Amino Acid Co., Ltd. ,  Zhejiang University ,  Zhejiang Nhu Co., Ltd.

    Inventor： Zhirong Chen ,  Zhixuan Wang ,  Cong Chen ,  Zhengjiang Wang ,  Cunchao Wang ,  Yin Li ,  Zhixiang Zhang

    IPC: B01D9/00 ,  C07C319/28 ,  C07C323/58

    CPC classification number: B01D9/0036 ,  B01D9/0013 ,  B01D9/0027 ,  B01D9/0054 ,  B01D2009/0086 ,  C07C319/28 ,  C07C323/58

    Abstract: The present disclosure relates to a method for continuous preparation of high bulk density methionine crystals. The process of the method is as follows: a hydrolysate solution, which is obtained from a reaction of 5-(β-methylmercaptoethyl) hydantoin and a potassium carbonate solution, is mixed with an external circulation material from a DTB neutralization crystallizer having a gas phase neutralization section; after being cooled, the mixture enters a liquid distributor of a neutralization region in the upper part of the crystallizer and is sprayed in the form of liquid droplet or trickle into carbon dioxide gas for neutralization reaction, and then naturally falls into a crystallization region in the lower part to be mixed with a material in the region; the obtained mixture grows on fine crystals in a system to form crystals having larger particle diameters, and meanwhile new crystal nucleuses are formed; in a deposition area in the middle part of the crystallization region, the crystals having larger particle diameters deposits into an elutriation leg, while the fine crystals circulate with the external circulation material, and a part of the external circulation material is used to elutriate the crystals in the elutriation leg, while another part of the same is used to be mixed with the hydrolysate solution; and the crystals in the elutriation leg are separated, washed and dried to obtain the high bulk density methionine product.

    Crystalline phase of (3S.3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) with L-lysine
    5.
    发明授权
    Crystalline phase of (3S.3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) with L-lysine 有权
    （3S.3S'）4,4'-二硫代二烷基双（3-氨基丁烷-1-磺酸）与L-赖氨酸的结晶相

    公开(公告)号：US09278921B2

    公开(公告)日：2016-03-08

    申请号：US14437343

    申请日：2013-10-22

    Applicant: Quantum Genomics

    Inventor： Fabrice Balavoine ,  Jean-Marie Schneider ,  Gérard Coquerel ,  Nicolas Couvrat

    IPC: C07C323/66 ,  C07C229/26 ,  A61K31/145 ,  A61K47/18

    CPC classification number: C07C319/28 ,  A61K31/145 ,  A61K47/183 ,  C07B2200/13 ,  C07C227/42 ,  C07C229/26 ,  C07C323/66

    Abstract: The present invention relates to a new crystalline phase of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and its use, particularly in the pharmaceutical industry, and to processes for preparation thereof. The invention is also directed to pharmaceutical compositions containing at least one crystalline phase of (3S,3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) (ABSD) with L-lysine and to the therapeutic or prophylactic use of such crystalline phase and compositions comprising the same.

    Abstract translation: 本发明涉及具有L-赖氨酸的（3S，3S'）4,4'-二磺酰基双（3-氨基丁烷-1-磺酸）（ABSD）的新结晶相及其用途，特别是在制药工业中，以及 其制备方法。 本发明还涉及含有（3S，3S'）4,4'-二磺酰基双（3-氨基丁烷-1-磺酸）（ABSD）与L-赖氨酸的至少一个结晶相和治疗或预防用途的药物组合物 的这种结晶相和包含它们的组合物。

    Configurations and methods for removal of mercaptans from feed gases
    7.
    发明授权
    Configurations and methods for removal of mercaptans from feed gases 有权
    从进料气体中除去硫醇的配置和方法

    公开(公告)号：US08377403B2

    公开(公告)日：2013-02-19

    申请号：US12375337

    申请日：2007-07-30

    Applicant: John Mak

    Inventor： John Mak

    IPC: B01D47/02 ,  B01D53/48 ,  B01D53/52 ,  B01D53/14 ,  B01D53/18

    CPC classification number: C10G45/02 ,  B01D53/1431 ,  B01D53/1487 ,  B01D53/1493 ,  B01D53/48 ,  B01D2252/205 ,  B01D2257/304 ,  B01D2257/306 ,  B01D2257/308 ,  B01D2258/06 ,  C01B17/0408 ,  C01B32/50 ,  C07C319/28 ,  C10G2300/202 ,  C10G2300/207 ,  C10L3/103 ,  C10L3/12 ,  C07C321/04

    Abstract: Contemplated configurations and methods employ COS hydrolysis and a downstream H2S removal unit to produce a treated feed gas that is then further desulfurized in an absorber using two lean oil fluids. The so produced mercaptan enriched hydrocarbon fluid is fed to a distillation column that produces a light overhead vapor that is preferably combined with the treated feed gas and a sulfur rich bottom product that is in most cases preferably directly fed to a hydrocarbon processing unit comprising a hydrotreater. In further especially preferred aspects, the hydrocarbon processing unit produces at least one and more typically both of the two lean oil fluids, and the treated gas is optionally further processed to produce clean fuel gas in a hydrotreater for olefinic saturation and sulfur conversion using a lean oil recycle for reactor temperature control.

    Abstract translation: 考虑的配置和方法采用COS水解和下游H2S去除单元来产生经处理的进料气体，然后使用两种贫油流体在吸收器中进一步脱硫。 将如此制得的富硫醇硫醇流体进料到蒸馏塔中，该蒸馏塔产生轻质塔顶蒸气，其优选与经处理的进料气体和富含硫的底部产物组合，在大多数情况下优选直接进料至包含加氢处理器 。 在进一步特别优选的方面，烃处理单元产生至少一种并且更典型地两种贫油流体，并且任选地处理的气体进一步处理以在加氢处理器中产生清洁燃料气体，用于烯烃饱和和硫转化，使用稀 用于反应器温度控制的油循环。

    Process for producing methionine
    8.
    发明授权
    Process for producing methionine 有权
    生产甲硫氨酸的方法

    公开(公告)号：US08106237B2

    公开(公告)日：2012-01-31

    申请号：US12480288

    申请日：2009-06-08

    Applicant: Yoshiyuki Koizumi ,  Fumio Kubo

    Inventor： Yoshiyuki Koizumi ,  Fumio Kubo

    IPC: C07C323/03

    CPC classification number: C07C319/20 ,  C07C319/28 ,  C07C323/58

    Abstract: The present invention provides a process for producing methionine, which comprises steps of: hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound in a non-stirred continuous first reaction tank, and heat-treating the reaction solution after hydrolysis in a second reaction tank. According to the process of the present invention, a methionine crystal with a higher bulk density can be produced.

    Abstract translation: 本发明提供了产生甲硫氨酸的方法，其包括以下步骤：在非搅拌连续的第一反应槽中，在碱性钾化合物的存在下水解5- [2-（甲硫基）乙基]咪唑烷-2,4-二酮 并在第二反应槽中水解后对反应溶液进行热处理。 根据本发明的方法，可以生产出具有较高堆积密度的蛋氨酸晶体。

    METHOD FOR OBTAINING OPTICALLY PURE AMINO ACIDS
    9.
    发明申请
    METHOD FOR OBTAINING OPTICALLY PURE AMINO ACIDS 有权
    获得光稳定氨基酸的方法

    公开(公告)号：US20120016157A1

    公开(公告)日：2012-01-19

    申请号：US13258948

    申请日：2010-03-19

    Applicant: Kwan-Mook Kim ,  Hojun Kim

    Inventor： Kwan-Mook Kim ,  Hojun Kim

    IPC: C07C227/36

    CPC classification number: C07C273/16 ,  C07B55/00 ,  C07B57/00 ,  C07B2200/07 ,  C07C227/34 ,  C07C227/36 ,  C07C319/28 ,  C07D209/20 ,  C07C275/32 ,  C07C229/36 ,  C07C229/22 ,  C07C229/08 ,  C07C323/58

    Abstract: This invention relates to a method for obtaining optically pure amino acids, including optical resolution and optical conversion. This method significantly shortens the time taken for optical transformation, and enables the repeated use of an organic solution containing a enantioselective receptor, to thereby obtain optically pure amino acids in a simple and remarkably efficient manner, and to enable the very economical mass production of optically pure amino acids.

    Abstract translation: 本发明涉及一种获得光学纯氨基酸的方法，包括光学分辨率和光学转换。 该方法显着缩短了光学转化所需的时间，并且能够重复使用含有对映选择性受体的有机溶液，从而以简单且显着有效的方式获得光学纯氨基酸，并且能够非常经济地批量生产光学 纯氨基酸。

    Process For Isolating Mono-Carboxy Substituted Probucol Derivatives
    10.
    发明申请
    Process For Isolating Mono-Carboxy Substituted Probucol Derivatives 审中-公开
    用于分离单羧基取代的Probucol衍生物的方法

    公开(公告)号：US20100324328A1

    公开(公告)日：2010-12-23

    申请号：US12666101

    申请日：2008-06-25

    Applicant: Jeremy Stephen Parker ,  Evan William Snape

    Inventor： Jeremy Stephen Parker ,  Evan William Snape

    IPC: C07C67/58

    CPC classification number: C07C319/20 ,  C07C319/28 ,  C07C323/20

    Abstract: A process for isolating a compound of formula (I) or a salt thereof, where X and R1 are as defined in the specification, from a mixture containing it, and the corresponding diacid and dihydroxy derivative, said process comprising (i) adding to an organic solution containing said compounds, water and a one or more salts, all of which are bases selected from a carbonate or hydrogen carbonate base, (ii) separating the aqueous phase containing the compound of formula (II) from the organic phase containing the compounds of formula (I) and (III); then (iii) recovering the compound of formula (I) from remaining organic phase. The process provides for efficient isolation of the target compound, even on a large scale.

    Abstract translation: 一种分离式（I）化合物或其盐的方法，其中X和R 1如说明书中所定义，含有它的混合物和相应的二酸和二羟基衍生物，所述方法包括（i）加入到 含有所述化合物的有机溶液，水和一种或多种盐，其全部为选自碳酸盐或碳酸氢盐碱的碱，（ii）将含有式（II）化合物的水相与含有化合物的有机相分离 的式（I）和（III）; 然后（iii）从剩余的有机相中回收式（I）化合物。 该方法即使在大规模的情况下也能有效地分离目标化合物。

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