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![LIQUID FORMULATIONS OF SALTS OF 4-[2-(4-METHYLPHENYLSULFANYL)PHENYL]PIPERIDINE](/abs-image/US/2010/04/29/US20100105730A1/abs.jpg.150x150.jpg)
1.发明申请LIQUID FORMULATIONS OF SALTS OF 4-[2-(4-METHYLPHENYLSULFANYL)PHENYL]PIPERIDINE 审中-公开4- [2-（4-甲基苯基）苯基]哌嗪的液体液体制剂公开(公告)号：US20100105730A1
公开(公告)日：2010-04-29
申请号：US12527907
申请日：2008-03-14
IPC分类号： A61K31/445 , C07D211/20 , A61P25/00
CPC分类号： A61K31/451 , A61K9/0095 , C07D211/20
摘要： Liquid formulations of the DL-lactic acid, the glutaric acid, the L-aspartic acid and the glutamic acid salts of 4-[2-(4-methylphenylsulfanyl)phenyl]piperidine and their use in the manufacture of a medicament to be used in the treatment of CNS diseases are provided.
摘要翻译： 4- [2-（4-甲基苯基硫烷基）苯基]哌啶的DL-乳酸，戊二酸，L-天冬氨酸和谷氨酸盐的液体制剂及其在制备用于 提供CNS疾病的治疗。
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公开(公告)号：US08501226B2
公开(公告)日：2013-08-06
申请号：US13606511
申请日：2012-09-07
CPC分类号： A61K31/60 , A61K9/1635 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K31/606
摘要： The present invention concerns a method for coating granules comprising mesalazine, with a coating mixture comprising two polymers, polymer I and polymer II; said polymer I being selected to allow formation of a closing membrane around said granules in the absence of said polymer II, and said polymer II being selected to act as a water-soluble pore former in said coating mixture; wherein a) the amount of polymer I is adjusted to provide a closing membrane in the absence of polymer II, and b) the amount of polymer II in said coating mixture is adjusted to obtain coated granules which exhibit controlled release of mesalazine. The invention further concerns a product obtainable by the coating method.
摘要翻译： 本发明涉及包含美沙拉嗪的颗粒的包衣方法，包括两种聚合物，聚合物I和聚合物II的涂料混合物; 所述聚合物I被选择为允许在不存在所述聚合物II的情况下在所述颗粒周围形成封闭膜，并且所述聚合物II被选择作为所述涂料混合物中的水溶性成孔剂; 其中a）调节聚合物I的量以在不存在聚合物II的情况下提供闭合膜，和b）调节所述涂料混合物中聚合物II的量，以获得展示美沙拉嗪的受控释放的包衣颗粒。 本发明还涉及通过涂布方法可获得的产品。
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公开(公告)号：US20120328698A1
公开(公告)日：2012-12-27
申请号：US13606511
申请日：2012-09-07
CPC分类号： A61K31/60 , A61K9/1635 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K31/606
摘要： The present invention concerns a method for coating granules comprising mesalazine, with a coating mixture comprising two polymers, polymer I and polymer II; said polymer I being selected to allow formation of a closing membrane around said granules in the absence of said polymer II, and said polymer II being selected to act as a water-soluble pore former in said coating mixture; wherein a) the amount of polymer I is adjusted to provide a closing membrane in the absence of polymer II, and b) the amount of polymer II in said coating mixture is adjusted to obtain coated granules which exhibit controlled release of mesalazine. The invention further concerns a product obtainable by the coating method.
摘要翻译： 本发明涉及包含美沙拉嗪的颗粒的包衣方法，包括两种聚合物，聚合物I和聚合物II的涂料混合物; 所述聚合物I被选择为允许在不存在所述聚合物II的情况下在所述颗粒周围形成封闭膜，并且所述聚合物II被选择作为所述涂料混合物中的水溶性成孔剂; 其中a）调节聚合物I的量以在不存在聚合物II的情况下提供闭合膜，和b）调节所述涂料混合物中聚合物II的量，以获得展示美沙拉嗪的受控释放的包衣颗粒。 本发明还涉及通过涂布方法可获得的产品。
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公开(公告)号：US08282958B2
公开(公告)日：2012-10-09
申请号：US10583669
申请日：2004-12-16
CPC分类号： A61K31/60 , A61K9/1635 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K31/606
摘要： The present invention concerns a method for coating granules comprising mesalazine, with a coating mixture comprising two polymers, polymer I and polymer II; said polymer I being selected to allow formation of a closing membrane around said granules in the absence of said polymer II, and said polymer II being selected to act as a water-soluble pore former in said coating mixture; wherein a) the amount of polymer I is adjusted to provide a closing membrane in the absence of polymer II, and b) the amount of polymer II in said coating mixture is adjusted to obtain coated granules which exhibit controlled release of mesalazine. The invention further concerns a product obtainable by the coating method.
摘要翻译： 本发明涉及包含美沙拉嗪的颗粒的包衣方法，包括两种聚合物，聚合物I和聚合物II的涂料混合物; 所述聚合物I被选择为允许在不存在所述聚合物II的情况下在所述颗粒周围形成封闭膜，并且所述聚合物II被选择作为所述涂料混合物中的水溶性成孔剂; 其中a）调节聚合物I的量以在不存在聚合物II的情况下提供闭合膜，和b）调节所述涂料混合物中聚合物II的量，以获得展示美沙拉嗪的受控释放的包衣颗粒。 本发明还涉及通过涂布方法可获得的产品。
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公开(公告)号：US20070154551A1
公开(公告)日：2007-07-05
申请号：US10583669
申请日：2004-12-16
申请人： Svenn Jepsen , Gudrun Lasskogen
发明人： Svenn Jepsen , Gudrun Lasskogen
CPC分类号： A61K31/60 , A61K9/1635 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K31/606
摘要： The present invention concerns a method for coating granules comprising mesalazine, with a coating mixture comprising two polymers, polymer I and polymer II; said polymer I being selected to allow formation of a closing membrane around said granules in the absence of said polymer II, and said polymer II being selected to act as a water-soluble pore former in said coating mixture; wherein a) the amount of polymer I is adjusted to provide a closing membrane in the absence of polymer II, and b) the amount of polymer II in said coating mixture is adjusted to obtain coated granules which exhibit controlled release of mesalazine. The invention further concerns a product obtainable by the coating method.
摘要翻译： 本发明涉及包含美沙拉嗪的颗粒的包衣方法，包括两种聚合物，聚合物I和聚合物II的涂料混合物; 所述聚合物I被选择为允许在不存在所述聚合物II的情况下在所述颗粒周围形成封闭膜，并且所述聚合物II被选择作为所述涂料混合物中的水溶性成孔剂; 其中a）调节聚合物I的量以在不存在聚合物II的情况下提供闭合膜，和b）调节所述涂料混合物中聚合物II的量，以获得展示美沙拉嗪的受控释放的包衣颗粒。 本发明还涉及通过涂布方法可获得的产品。
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