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公开(公告)号:US07323469B2
公开(公告)日:2008-01-29
申请号:US10783000
申请日:2004-02-20
IPC分类号: A61K31/519 , A61K31/497 , C07D487/04 , A61P35/04
CPC分类号: C07D487/04
摘要: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumor.
摘要翻译: 本发明涉及式I的7H-吡咯并[2,3-d]嘧啶衍生物,其中符号和取代基如说明书中所定义,其制备方法,包含该衍生物的药物组合物及其用途 衍生物 - 单独或与一种或多种其它药学活性化合物组合 - 用于制备用于治疗特别是增殖性疾病如肿瘤的药物组合物。
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公开(公告)号:US07390805B2
公开(公告)日:2008-06-24
申请号:US11686023
申请日:2007-03-14
IPC分类号: C07D413/10 , C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/497 , A06P35/04
CPC分类号: C07D487/04
摘要: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.
摘要翻译: 本发明涉及式I的7H-吡咯并[2,3-d]嘧啶衍生物,其中符号和取代基如说明书中所定义,其制备方法,包含该衍生物的药物组合物及其用途 衍生物 - 单独或与一种或多种其它药学活性化合物组合 - 用于制备用于治疗特别是增殖性疾病如肿瘤的药物组合物。
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公开(公告)号:US07244729B2
公开(公告)日:2007-07-17
申请号:US10485747
申请日:2002-08-06
IPC分类号: C07D413/10 , C07D487/04 , A61K31/519 , A61K31/5355 , A61P35/00
CPC分类号: C07D487/04
摘要: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives-alone or in combination with one or more other pharmaceutically active compounds-for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour
摘要翻译: 本发明涉及式I的7H-吡咯并[2,3-d]嘧啶衍生物,其中符号和取代基如说明书中所定义,其制备方法,包含该衍生物的药物组合物及其用途 衍生物 - 单独或与一种或多种其它药学活性化合物组合 - 用于制备用于治疗特别是增殖性疾病如肿瘤的药物组合物
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公开(公告)号:US20070161632A1
公开(公告)日:2007-07-12
申请号:US11686023
申请日:2007-03-14
IPC分类号: A61K31/5377 , A61K31/519 , C07D487/04
CPC分类号: C07D487/04
摘要: The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.
摘要翻译: 本发明涉及式I的7H-吡咯并[2,3-d]嘧啶衍生物,其中符号和取代基如说明书中所定义,其制备方法,包含该衍生物的药物组合物及其用途 衍生物 - 单独或与一种或多种其它药学活性化合物组合 - 用于制备用于治疗特别是增殖性疾病如肿瘤的药物组合物。
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公开(公告)号:US08026247B2
公开(公告)日:2011-09-27
申请号:US11575025
申请日:2005-09-14
申请人: Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Andreas Floersheimer , Pascal Furet , Paul W. Manley , Andrea Vaupel
发明人: Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Andreas Floersheimer , Pascal Furet , Paul W. Manley , Andrea Vaupel
IPC分类号: C07D239/46 , C07D403/12 , C07D413/12 , A61K31/505
CPC分类号: C07D239/47 , C07D403/12 , C07D413/12
摘要: The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.
摘要翻译: 本发明涉及式(I)化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,特别是肿瘤疾病。
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公开(公告)号:US20110301157A1
公开(公告)日:2011-12-08
申请号:US13211765
申请日:2011-08-17
申请人: Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Andreas Floersheimer , Pascal Furet , Paul W. Manley , Andrea Vaupel , Carole Pissot Soldermann , Francois Gessier , Christian Schnell , Amanda Jane Littlewood-Evans , Prasad Koteswara Kapa , Joginder S. Bajwa , Xinglong Jiang
发明人: Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Andreas Floersheimer , Pascal Furet , Paul W. Manley , Andrea Vaupel , Carole Pissot Soldermann , Francois Gessier , Christian Schnell , Amanda Jane Littlewood-Evans , Prasad Koteswara Kapa , Joginder S. Bajwa , Xinglong Jiang
IPC分类号: A61K31/538 , A61K31/496 , A61K31/505 , C07D413/12 , C07D413/14 , C07D401/14 , C07D239/34 , A61K31/506 , C07D401/12 , A61P17/06 , A61P29/00 , A61P11/06 , A61P9/00 , A61P25/28 , A61P35/02 , A61P35/00 , C07D403/12 , A61P3/10 , A61P37/00 , A61P41/00 , A61K31/5377
CPC分类号: C07D239/47 , C07D403/12 , C07D413/12
摘要: The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.
摘要翻译: 本发明涉及式(I)化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,特别是肿瘤疾病。
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公开(公告)号:US20080287427A1
公开(公告)日:2008-11-20
申请号:US11575025
申请日:2005-09-14
申请人: Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Andreas Floersheimer , Pascal Furet , Paul W. Manley , Andreas Vaupel , Carole Pissot Soldermann , Francois Gessier , Christian Schnell , Amanda Jane Littlewood-Evans , Prasad Koteswara Kapa , Joginder S. Bajwa , Xinglong Jiang
发明人: Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Andreas Floersheimer , Pascal Furet , Paul W. Manley , Andreas Vaupel , Carole Pissot Soldermann , Francois Gessier , Christian Schnell , Amanda Jane Littlewood-Evans , Prasad Koteswara Kapa , Joginder S. Bajwa , Xinglong Jiang
IPC分类号: A61K31/5377 , C07D403/12 , A61K31/506 , C07D213/72 , C07D413/02
CPC分类号: C07D239/47 , C07D403/12 , C07D413/12
摘要: The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising en a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.
摘要翻译: 本发明涉及式(I)化合物及其在治疗动物或人体中的用途,包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途 用于治疗蛋白激酶依赖性疾病,特别是增殖性疾病,特别是肿瘤疾病。
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公开(公告)号:US5354761A
公开(公告)日:1994-10-11
申请号:US69660
申请日:1993-06-01
IPC分类号: A61K31/44 , A61K31/4402 , A61K31/4418 , A61P33/02 , C07D213/78 , C07D213/81 , C07D213/83 , C07D401/04
CPC分类号: C07D213/78 , C07D213/81 , C07D213/83
摘要: Compounds of formula I ##STR1## wherein Y, Z, S, S', m, n and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are effective especially against protozoal infections. They are prepared in a manner known per se.
摘要翻译: 其中Y,Z,S,S',m,n和R 1 -R 4如说明书中所定义的式I化合物(I)具有有价值的药物性质,并且尤其对抗原生动物感染是有效的。 它们是以本身已知的方式准备的。
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公开(公告)号:US5238941A
公开(公告)日:1993-08-24
申请号:US849262
申请日:1992-03-11
IPC分类号: C07C281/18 , C07C337/08 , C07D213/78 , C07D239/30 , C07D401/04
CPC分类号: C07D213/78 , C07C281/18 , C07C337/08 , C07D239/30 , C07D401/04
摘要: Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.
摘要翻译: 其中A,X 1,X 2,X 3,X 4,Y,Z和R 1至R 6具有说明书中给出的含义的式I化合物(I)具有有价值的药物性质,尤其对肿瘤有效。 它们是以本身已知的方式准备的。
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公开(公告)号:US20100305113A1
公开(公告)日:2010-12-02
申请号:US12599131
申请日:2008-05-07
IPC分类号: A61K31/542 , C07D487/04 , A61K31/5025 , A61K31/5377 , A61P35/00 , A61P29/00 , A61P37/08 , A61P9/00
CPC分类号: C07D487/04
摘要: The invention relates to novel compounds of the formula I, as well as other invention embodiments related to these compounds. The compounds are e.g. useful in the treatment of the animal or human body in view of their ability to inhibit protein kinases such as especially PI3 kinase.
摘要翻译: 本发明涉及式I的新化合物以及与这些化合物有关的其它发明实施方案。 化合物是例如 鉴于其抑制蛋白激酶(例如PI3激酶)的能力,可用于动物或人体的治疗。
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