公开(公告)号：US07439263B2

公开(公告)日：2008-10-21

申请号：US11131510

申请日：2005-05-18

申请人： Guillaume De Nanteuil ,  Alain Benoist ,  Murielle Combettes ,  Elizabeth Harley

发明人： Guillaume De Nanteuil ,  Alain Benoist ,  Murielle Combettes ,  Elizabeth Harley

IPC分类号： A61K31/40 ,  C07D207/04

CPC分类号： C07D405/12 ,  C07D207/10 ,  C07D207/16 ,  C07D277/12 ,  C07D295/185 ,  C07D403/12 ,  C07D409/12 ,  C07D417/12

摘要： Compounds of formula (I): wherein: X1 represents an atom or group selected from CR4aR4b, O, S(O)q1 and NR5, wherein R4a, R4b, q1 and R5 are as defined in the description, m1 represents zero or an integer from 1 to 4 inclusive, m2 represents an integer from 1 to 4 inclusive, n1 and n2, which may be identical or different, each represent an integer from 1 to 3 inclusive, R1 represents hydrogen or a group selected from carboxy, alkoxycarbonyl, optionally substituted carbamoyl and optionally substituted alkyl, R2 represents hydrogen or alkyl, Ak represents an optionally substituted alkylene chain, p represents zero, 1 or 2, R3 represents hydrogen or cyano, X2 and X3, which may be identical or different, each represent either S(O)q2, or CR6aR6b, wherein q2, R6a and R6b are as defined in the description, its optical isomers, where they exist, and its addition salts with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful as DPP-IV inhibitors.

摘要翻译： 式（I）的化合物：其中：X 1表示选自CR 4a R 4a，O，S（O） q1和NR5，其中R 4a 4a，R 4b，q 1和...， R 5如描述中所定义，m 1表示0或1至4的整数，其中m 2表示1的整数， 至4个，其中可以相同或不同的n 1和n 2各自表示1至3的整数，包括1和3的整数，R 1， 表示氢或选自羧基，烷氧基羰基，任选取代的氨基甲酰基和任选取代的烷基的基团，R 2表示氢或烷基，Ak表示任选取代的亚烷基链，p表示0,1或2，R 3或3表示氢或氰基，X 2和X 3可以相同或不同，各自表示S（O） q2，或CR 6a R 6b，其中q2

公开(公告)号：US20050261501A1

公开(公告)日：2005-11-24

申请号：US11131510

申请日：2005-05-18

申请人： Guillaume De Nanteuil ,  Alain Benoist ,  Murielle Combettes ,  Elizabeth Harley

发明人： Guillaume De Nanteuil ,  Alain Benoist ,  Murielle Combettes ,  Elizabeth Harley

IPC分类号： C07D295/18 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/426 ,  A61K31/427 ,  A61K31/438 ,  A61P3/10 ,  A61P43/00 ,  C07D207/06 ,  C07D207/10 ,  C07D207/16 ,  C07D277/06 ,  C07D277/12 ,  C07D295/185 ,  C07D311/96 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D211/22

CPC分类号： C07D405/12 ,  C07D207/10 ,  C07D207/16 ,  C07D277/12 ,  C07D295/185 ,  C07D403/12 ,  C07D409/12 ,  C07D417/12

摘要： Compounds of formula (I): wherein: X1 represents an atom or group selected from CR4aR4b, O, S(O)q1 and NR5, wherein R4a, R4b, q1 and R5 are as defined in the description, m1 represents zero or an integer from 1 to 4 inclusive, m2 represents an integer from 1 to 4 inclusive, n1 and n2, which may be identical or different, each represent an integer from 1 to 3 inclusive, R1 represents hydrogen or a group selected from carboxy, alkoxycarbonyl, optionally substituted carbamoyl and optionally substituted alkyl, R2 represents hydrogen or alkyl, Ak represents an optionally substituted alkylene chain, p represents zero, 1 or 2, R3 represents hydrogen or cyano, X2 and X3, which may be identical or different, each represent either S(O)q2, or CR6aR6b, wherein q2, R6a and R6b are as defined in the description, its optical isomers, where they exist, and its addition salts with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful as DPP-IV inhibitors.

摘要翻译： 式（I）的化合物：其中：X 1表示选自CR 4a R 4a，O，S（O） q1和NR5，其中R 4a 4a，R 4b，q 1和...， R 5如描述中所定义，m 1表示0或1至4的整数，其中m 2表示1的整数， 至4个，其中可以相同或不同的n 1和n 2各自表示1至3的整数，包括1和3的整数，R 1， 表示氢或选自羧基，烷氧基羰基，任选取代的氨基甲酰基和任选取代的烷基的基团，R 2表示氢或烷基，Ak表示任选取代的亚烷基链，p表示0,1或2，R 3或3表示氢或氰基，X 2和X 3可以相同或不同，各自表示S（O） q2，或CR 6a R 6b，其中q2