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1.发明授权Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells 失效电穿孔和离子电渗疗法以及将药物和基因插入细胞的方法
公开(公告)号：US5507724A
公开(公告)日：1996-04-16
申请号：US183963
申请日：1994-01-21
摘要： A catheter device having a plurality of axially extending, circumferentially spaced electrodes carried thereby, infusion means for infusion of fluid medium for carrying genes and drugs, and expandable sealing means at each end of the electrodes for sealing off and confining the therapeutic medium to the area to be treated is inserted into a selected blood vessel of a patient and advanced to a preselected location within the blood vessel where cells on or near the wall of the vessel are to be treated. Once in place, the catheter device is expanded so that the plurality of axially extending, circumferentially spaced electrodes carried thereby are in contact with the inner wall of the blood vessel and seals at each end of the electrodes expand and seal the catheter device in the preselected location. A quantity of therapeutic genes or drugs is infused into the area of the electrodes via a tube and a conventional pump. A power pack connected to the electrodes is energized subjecting the cells to electric fields of predetermined amplitude and duration making the walls of the cells transiently permeable to enabling therapeutic genes or drugs carried by the fluid medium to enter the cells without killing them.
摘要翻译： 导管装置，其具有多个沿轴向延伸的周向隔开的电极，由此输送用于输送用于携带基因和药物的流体介质的输注装置，以及用于密封和限制治疗介质至该区域的电极的每个端部处的可膨胀密封装置 被处理的细胞被插入到患者的选定的血管中并且前进到血管内的预定位置，其中待处理血管壁上或其附近的细胞。 一旦就位，导管装置被扩张，使得由其携带的多个沿轴向延伸的周向间隔开的电极与血管的内壁接触，并且在电极的每个端部处的密封件将预先选定的导管装置膨胀和密封 位置。 一些治疗基因或药物通过管和常规泵注入电极区域。 连接到电极的电源组通电使细胞进入具有预定振幅和持续时间的电场，使得细胞壁瞬时渗透，使得流体介质携带的治疗基因或药物进入细胞而不杀死细胞。
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公开(公告)号：US5704908A
公开(公告)日：1998-01-06
申请号：US729007
申请日：1996-10-10
摘要： An electroporation apparatus for introducing molecules into cells at a selected location within a cavity in the body of a patient includes an elongated catheter having a proximal end and a distal end and a guide wire extending from the proximal end to the distal end, an inflatable balloon carried by the distal end, the balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber between the two bladders, a first electrode on an outer surface of the outer perforated bladder, a second electrode spaced from the first electrode, a remote electrode, a lumen for delivering a predetermined quantity of a fluid medium carrying preselected molecules into the chamber to be infused into the body cavity at the predetermined location; and a source of power for applying a voltage pulse between selected pairs of the electrodes for transport of the molecules by iontophoresis and/or repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter the cells.
摘要翻译： 用于在患者体内的空腔内的选定位置处将分子引入细胞的电穿孔装置包括具有近端和远端的细长导管和从近端延伸到远端的导丝，可膨胀气囊 所述气囊具有内部可充气气囊和在所述两个气囊之间限定室的外部穿孔气囊，所述外部穿孔气囊的外表面上的第一电极，与所述第一电极间隔开的第二电极，远端 电极，用于将预定量的携带预选分子的流体介质输送到所述腔室中以在预定位置输注到体腔内腔; 以及用于在所选择的电极对之间施加电压脉冲的电源，用于通过离子电渗传输分子和/或重复产生预定幅度和持续时间的电场，从而诱导预定位置处的多个电池的壁为 瞬时渗透以使分子进入细胞。
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3.发明授权Electroporation method and apparatus for insertion of drugs and genes into endothelial cells 失效用于将药物和基因插入内皮细胞的电穿孔方法和装置
公开(公告)号：US5304120A
公开(公告)日：1994-04-19
申请号：US907322
申请日：1992-07-01
摘要： A catheter device is inserted into a selected blood vessel of a patient and advanced to a preselected location within the blood vessel where the endothelial cells on the inner wall of the vessel are to be treated. Once in place, the catheter device is expanded so that a plurality of axially extending, circumferentially spaced electrodes carried thereby are in contact with the inner wall of the blood vessel. A fluid medium is then infused into the blood vessel adjacent the electrodes via a conventional pump. A power pack connected to the electrodes is energized to apply a predetermined electric signal to the electrodes. This subjects the endothelial cells to electric fields of predetermined amplitude and duration in order to make the walls of the endothelial cells transiently permeable to permit therapeutic genes or drugs carried by the fluid medium to enter the endothelial cells without killing them.
摘要翻译： 将导管装置插入到患者的所选择的血管中并且前进到血管内预先选定的位置，其中血管内壁上的内皮细胞将被处理。 一旦就位，导管装置被扩张，使得由其携带的多个轴向延伸的周向隔开的电极与血管的内壁接触。 然后通过常规泵将流体介质输入到与电极相邻的血管中。 连接到电极的电源组通电以向电极施加预定的电信号。 这将使内皮细胞受到预定幅度和持续时间的电场，以使内皮细胞的壁瞬时渗透以允许治疗基因或由流体介质携带的药物进入内皮细胞而不杀死它们。
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