公开(公告)号：US20050214212A1

公开(公告)日：2005-09-29

申请号：US11136538

申请日：2005-05-25

申请人： Gunther Adolf ,  Elinborg Ostermann ,  Erik Patzelt ,  Marlies Sproll ,  Karl-Heinz Heider ,  John Miglietta ,  Augustinus Antonius Van Dongen

发明人： Gunther Adolf ,  Elinborg Ostermann ,  Erik Patzelt ,  Marlies Sproll ,  Karl-Heinz Heider ,  John Miglietta ,  Augustinus Antonius Van Dongen

IPC分类号： C07K16/28 ,  A61K51/00 ,  A61K39/395 ,  C07H21/04 ,  C12N15/09 ,  C12P21/06

CPC分类号： C07K16/2884 ,  A61K2039/505 ,  C07K2319/00 ,  C12N2799/021

摘要： The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.

摘要翻译： 本发明属于肿瘤学领域。 本发明涉及具有特定序列的抗体，其对于由CD44基因的变体外显子v6编码的表位和所述抗体的衍生物是特异性的。 本发明还提供编码所述抗体蛋白质的核酸分子。 本发明还涉及生产所述抗体蛋白质的方法。 本发明还提供包含所述抗体蛋白质的药物组合物。 本发明还涉及在制备用于治疗癌症的药物中的用途。