-
公开(公告)号：US07417127B2
公开(公告)日：2008-08-26
申请号：US11136538
申请日：2005-05-25
申请人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
发明人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
IPC分类号： C12P21/08
CPC分类号： C07K16/2884 , A61K2039/505 , C07K2319/00 , C12N2799/021
摘要： The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.
摘要翻译： 本发明属于肿瘤学领域。 本发明涉及具有特定序列的抗体，其对于由CD44基因的变体外显子v6编码的表位和所述抗体的衍生物是特异性的。 本发明还提供编码所述抗体蛋白质的核酸分子。 本发明还涉及生产所述抗体蛋白质的方法。 本发明还提供包含所述抗体蛋白质的药物组合物。 本发明还涉及在制备用于治疗癌症的药物中的用途。
-
公开(公告)号：US5618712A
公开(公告)日：1997-04-08
申请号：US225280
申请日：1994-04-04
申请人： Andrzej Sledziewski , Ewa Chlebowicz-Sledziewska , Peter Swetly , Gunther Adolf , Rudolf Hauptmann , Maria J. Castanon , Walter Spevak
发明人： Andrzej Sledziewski , Ewa Chlebowicz-Sledziewska , Peter Swetly , Gunther Adolf , Rudolf Hauptmann , Maria J. Castanon , Walter Spevak
IPC分类号： C12N15/09 , A61K35/74 , A61K36/06 , A61K38/00 , A61K38/46 , C07K14/00 , C12N1/16 , C12N1/20 , C12N5/00 , C12N5/10 , C12N9/36 , C12N15/56 , C12N15/81 , C12R1/19 , C12R1/865 , C12R1/91 , C12N15/70
CPC分类号： C12N9/2462 , C12N15/81 , A61K38/00
摘要： This invention relates to a process for preparing human lysozyme and the human lysozyme protein itself.
摘要翻译： 本发明涉及一种制备人溶菌酶和人溶菌酶蛋白的方法。
-
公开(公告)号：US4791101A
公开(公告)日：1988-12-13
申请号：US746793
申请日：1985-06-20
申请人： Gunther Adolf
发明人： Gunther Adolf
CPC分类号： A61K38/21
摘要： Ternary compositions of an interferon of the alpha and/or beta type with an interferon of the gamma type and tumor necrosis factor having a surprising and unexpected synergistic anti-proliferative effect on neoplastic cells when compared to the activity of the individual components of this invention, said compositions being useful in the treatment of neoplasia in animals including humans.
摘要翻译： 当与本发明的各个组分的活性相比，具有γ型和肿瘤坏死因子的干扰素的α和/或β型干扰素的三元组合物对肿瘤细胞具有惊人的和意想不到的协同抗增殖作用， 所述组合物可用于治疗包括人在内的动物的瘤形成。
-
公开(公告)号：US5798228A
公开(公告)日：1998-08-25
申请号：US805165
申请日：1997-02-24
申请人： Adolf Himmler , Rudolf Hauptmann , Norbert Hauel , Gunther Adolf , Peter Swetly
发明人： Adolf Himmler , Rudolf Hauptmann , Norbert Hauel , Gunther Adolf , Peter Swetly
IPC分类号： A61K38/21 , A61K38/00 , A61P31/12 , A61P35/00 , A61P37/04 , A61P43/00 , C07H21/04 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/565 , C07K16/00 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/20 , C12N15/21 , C12P21/02 , C12R1/19
CPC分类号： C07K14/555 , A61K38/00
摘要： This invention relates to a process for preparing recombinant horse and dog interferons and the interferons themselves.
摘要翻译： 本发明涉及一种制备重组马和狗干扰素和干扰素本身的方法。
-
5.发明授权Hybrid interferons, their use as pharmaceutical compositions and as intermediate products for the preparation of antibodies and the use thereof and processes for preparing them 失效混合干扰素，它们作为药物组合物的用途以及用于制备抗体的中间产物及其用途及其制备方法
公开(公告)号：US4917887A
公开(公告)日：1990-04-17
申请号：US23634
申请日：1987-03-09
申请人： Rudolf Hauptmann , Peter Swetly , Peter Meindl , Gunther Adolf , Edgar Falkner , Gerhard Bodo , Ingrid Maurer-Fogy
发明人： Rudolf Hauptmann , Peter Swetly , Peter Meindl , Gunther Adolf , Edgar Falkner , Gerhard Bodo , Ingrid Maurer-Fogy
IPC分类号： C07K14/005 , A61K38/00 , A61K38/21 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/195 , C07K14/52 , C07K14/555 , C07K14/56 , C07K16/00 , C07K16/24 , C07K17/10 , C12N1/20 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/20 , C12N15/70 , C12N15/81 , C12P21/00 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/38 , C12R1/425 , C12R1/91
CPC分类号： C12N15/70 , C07K14/555 , C07K14/56 , C07K16/249 , C12N15/81 , A61K38/00
摘要： This invention relates to new hybrid interferons consisting of part of an .alpha.-interferon and part of an omega interferon, the N-terminal Met or N-formyl-Met derivatives thereof and, if the peptide sequence of the hybrid interferon contains a glycosylation site, the N-glycosylated derivatives thereof, their use as pharmaceutical compositions and as intermediate products for immunizing experimental animals and processes for producing them,new monoclonal antibodies and their use in purifying .alpha. and omega-interferons, the hybrid cell lines which secrete them and processes for preparing them,a new process for purifying .alpha. and omega-interferons by means of a new antibody affinity column containing the above-mentioned new monoclonal antibodies, and processes for the preparation thereof,new hybrid plasmids for improving the expression of omega-interferons and new intermediate plasmids for preparing the new plasmids and processes for the preparation thereof.
摘要翻译： 本发明涉及由α-干扰素和ω-干扰素的一部分组成的新的杂合干扰素，其N-末端Met或N-甲酰基-Mc衍生物，如果杂合干扰素的肽序列含有糖基化位点， 其N-糖基化衍生物，它们作为药物组合物的用途和用于免疫实验动物的中间产物及其制备方法，新的单克隆抗体及其在纯化α和ω-干扰素中的用途，分泌它们的杂交细胞系和 制备它们，通过含有上述新单克隆抗体的新抗体亲和柱纯化α和ω-干扰素的新方法及其制备方法，用于改善ω-干扰素表达的新型杂合质粒和新的 用于制备新质粒的中间质粒及其制备方法。
-
公开(公告)号：US5605688A
公开(公告)日：1997-02-25
申请号：US302391
申请日：1994-09-08
申请人： Adolf Himmler , Rudolf Hauptmann , Norbert Hauel , Gunther Adolf , Peter Swetly
发明人： Adolf Himmler , Rudolf Hauptmann , Norbert Hauel , Gunther Adolf , Peter Swetly
IPC分类号： A61K38/21 , A61K38/00 , A61P31/12 , A61P35/00 , A61P37/04 , A61P43/00 , C07H21/04 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/565 , C07K16/00 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/20 , C12N15/21 , C12P21/02 , C12R1/19
CPC分类号： C07K14/555 , A61K38/00
摘要： This invention relates to a process for preparing recombinant horse and dog interferons and the interferons themselves.
摘要翻译： 本发明涉及一种制备重组马和狗干扰素以及干扰素本身的方法。
-
7.发明授权Monoclonal antibodies against IFN-omega, processes for preparing them and their use in the purification and detection of IFN-omega 失效针对IFN-ω的单克隆抗体，其制备方法及其在纯化和检测IFN-ω中的应用
公开(公告)号：US5317089A
公开(公告)日：1994-05-31
申请号：US102160
申请日：1987-09-28
申请人： Gunther Adolf
发明人： Gunther Adolf
IPC分类号： C12N15/02 , A61K38/21 , A61K39/395 , C07K1/22 , C07K14/005 , C07K14/195 , C07K14/52 , C07K14/555 , C07K16/00 , C07K16/24 , C07K19/00 , C12N5/00 , C12N5/10 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C07K15/14 , C07K15/26
CPC分类号： C07K14/555 , C07K16/249
摘要： The invention relates to new monoclonal antibodies which react specifically with human interferon of the IFN-omega type but not with other human interferons, and processes for preparing them, and for methods for their use in the purification and detection of IFN-omega.
摘要翻译： 本发明涉及与IFN-ω型的人干扰素特异性但不与其它人类干扰素特异性反应的新单克隆抗体及其制备方法，以及用于IFN-ω的纯化和检测的方法。
-
公开(公告)号：US20050214212A1
公开(公告)日：2005-09-29
申请号：US11136538
申请日：2005-05-25
申请人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John Miglietta , Augustinus Antonius Van Dongen
发明人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John Miglietta , Augustinus Antonius Van Dongen
CPC分类号： C07K16/2884 , A61K2039/505 , C07K2319/00 , C12N2799/021
摘要： The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.
摘要翻译： 本发明属于肿瘤学领域。 本发明涉及具有特定序列的抗体，其对于由CD44基因的变体外显子v6编码的表位和所述抗体的衍生物是特异性的。 本发明还提供编码所述抗体蛋白质的核酸分子。 本发明还涉及生产所述抗体蛋白质的方法。 本发明还提供包含所述抗体蛋白质的药物组合物。 本发明还涉及在制备用于治疗癌症的药物中的用途。
-
9.发明授权Vascular anticoagulant proteins DNA which codes them, processer for preparing them and their use 失效编码它们的血管抗凝蛋白DNA，用于制备它们的处理器及其用途
公开(公告)号：US5837842A
公开(公告)日：1998-11-17
申请号：US376050
申请日：1995-01-23
申请人： Rudolf Hauptmann , Ingrid Maurer-Fogy , Gerhard Bodo , Peter Swetly , Christian Stratowa , Edgar Falkner , Gunther Adolf , Christiaan Maria Peter Reutelingsperger
发明人： Rudolf Hauptmann , Ingrid Maurer-Fogy , Gerhard Bodo , Peter Swetly , Christian Stratowa , Edgar Falkner , Gunther Adolf , Christiaan Maria Peter Reutelingsperger
IPC分类号： G01N33/50 , A61K35/14 , A61K38/00 , A61P7/02 , A61P29/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K19/00 , C12N1/20 , C12N5/10 , C12N15/09 , C12N15/70 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/86 , C07H21/04
CPC分类号： C12N15/70 , C07K14/4721 , C07K16/18 , G01N33/86 , A61K38/00
摘要： This invention relates to biologically active proteins, the DNA molecules coding for them, processes for preparing them and their use.
摘要翻译： 本发明涉及生物活性蛋白质，编码它们的DNA分子，其制备方法及其应用。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.02 秒)
