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1.发明授权Immunogenic composition comprising variants of Staphylococcal clumping factor A 有权包含葡萄球菌聚集因子A的变体的免疫原性组合物公开(公告)号：US08715687B2
公开(公告)日：2014-05-06
申请号：US13388715
申请日：2010-08-03
IPC分类号： A61K39/085 , C07K14/31 , C12N15/00
CPC分类号： C07K16/1271 , A61K39/00 , A61K39/085 , A61K2039/522 , A61K2039/55566 , C07K14/31 , C07K2317/76
摘要： The present invention relates to ClfA polypeptides wherein amino acid Y474 or an amino acid adjacent to Y474 is mutated such that fibrinogen binding activity is decreased compared to an equivalent ClfA polypeptide without mutation of Y474 or an amino acid adjacent to Y474 as well as immunogenic compositions, vaccines, processes and uses of such mutated ClfA polypeptides.
摘要翻译： 本发明涉及其中氨基酸Y474或与Y474相邻的氨基酸突变以使纤维蛋白原结合活性与不具有Y474突变或Y474相邻氨基酸的等价ClfA多肽以及免疫原性组合物相比降低的ClfA多肽， 这些突变的ClfA多肽的疫苗，方法和用途。
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2.发明申请IMMUNOGENIC COMPOSITION COMPRISING VARIANTS OF STAPHYLOCOCCAL CLUMPING FACTOR A 有权含有血小板沉淀因子A变异的免疫组合物公开(公告)号：US20120189650A1
公开(公告)日：2012-07-26
申请号：US13388715
申请日：2010-08-03
IPC分类号： A61K39/085 , A61P31/04 , A61P37/04 , C07K14/31 , C12N15/31
CPC分类号： C07K16/1271 , A61K39/00 , A61K39/085 , A61K2039/522 , A61K2039/55566 , C07K14/31 , C07K2317/76
摘要： The present invention relates to ClfA polypeptides wherein amino acid Y474 or an amino acid adjacent to Y474 is mutated such that fibrinogen binding activity is decreased compared to an equivalent ClfA polypeptide without mutation of Y474 or an amino acid adjacent to Y474 as well as immunogenic compositions, vaccines, processes and uses of such mutated ClfA polypeptides.
摘要翻译： 本发明涉及其中氨基酸Y474或与Y474相邻的氨基酸突变以使纤维蛋白原结合活性与不具有Y474突变或Y474相邻氨基酸的等价ClfA多肽以及免疫原性组合物相比降低的ClfA多肽， 这些突变的ClfA多肽的疫苗，方法和用途。
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公开(公告)号：US20120141523A1
公开(公告)日：2012-06-07
申请号：US13388757
申请日：2010-08-03
IPC分类号： A61K39/085 , A61P31/04 , C07K14/31
CPC分类号： A61K39/085 , C07K14/31 , C07K2319/00
摘要： The present application relates to an immunogenic composition comprising a fragment of a staphylococcal Isd protein such as IsdA, IsdB, IsdC or IsdH which comprises a NEAT domain. Fusion proteins comprising a NEAT domain of a first staphylococcal Isd protein and a NEAT domain from a second Isd protein are also disclosed as well as fusion proteins comprising a NEAT domain of a staphylococcal Isd protein involved in an iron/heme uptake system and a ligand binding domain of a staphylococcal extracellular component binding protein, for example ClfA, ClfB, SdrC, SdrD or SdrE.
摘要翻译： 本申请涉及包含葡萄球菌Isd蛋白片段的免疫原性组合物，所述葡萄球菌Isd蛋白质包括NEAT结构域，所述IsdA，IsdB，IsdC或IsdH包含NEAT结构域。 还公开了包含第一葡萄球菌Isd蛋白的NEAT结构域和来自第二Isd蛋白的NEAT结构域的融合蛋白以及包含参与铁/血红素吸收系统和配体结合的葡萄球菌Isd蛋白的NEAT结构域的融合蛋白 葡萄球菌胞外成分结合蛋白的结构域，例如ClfA，ClfB，SdrC，SdrD或SdrE。
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