公开(公告)号：US20180362583A1

公开(公告)日：2018-12-20

申请号：US16113869

申请日：2018-08-27

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  UNIVERSITY OF SOUTH FLORIDA

发明人： Lori Hazlehurst ,  Mark McLaughlin ,  Priyesh Jain ,  William S. Dalton

IPC分类号： C07K7/06 ,  A61K45/06

摘要： Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.

公开(公告)号：US10059740B2

公开(公告)日：2018-08-28

申请号：US15165687

申请日：2016-05-26

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  UNIVERSITY OF SOUTH FLORIDA

发明人： Lori Hazlehurst ,  Mark McLaughlin ,  Priyesh Jain ,  William S. Dalton

IPC分类号： A61K38/00 ,  C07K7/06 ,  A61K38/08 ,  A61K45/06

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K38/08 ,  A61K45/06

摘要： Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.

公开(公告)号：US20170068789A1

公开(公告)日：2017-03-09

申请号：US15119852

申请日：2015-02-19

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  MOFFITT GENETICS CORPORATION (DBA M2GEN)

发明人： William S. Dalton ,  Eric B. Haura ,  Naveen Kumar ,  Eric Padron ,  Kenneth H. Shain ,  Eduardo M. Sotomayor

IPC分类号： G06F19/00

CPC分类号： G16H50/20 ,  G16H50/70

摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, including a system for providing treatment suggestions. The system includes a data warehouse including patient data for a plurality of patients associated with one or more care facilities, and one or more processors including instructions for implementing an evidence-based clinical decision engine. The engine is operable to: identify patient cohorts defined by the data in the data warehouse including identifying relevant cohorts that include a population of patients who are similar, both by phenotype and genotype, to a candidate patient; evaluate the patient cohorts to identify a cohort that is a best match for the candidate patient based on historical treatment information for patients in each candidate patient cohort; select a cohort from the plurality of cohorts; and provide a treatment suggestion to the patient or a care provider based on the selection.

摘要翻译： 方法，系统和装置，包括在计算机存储介质上编码的计算机程序，包括用于提供治疗建议的系统。 该系统包括数据仓库，包括与一个或多个护理设施相关联的多个患者的患者数据，以及包括用于实施基于证据的临床决策引擎的指令的一个或多个处理器。 引擎可操作地：识别由数据仓库中的数据定义的患者队列，包括识别相关队列，其包括通过表型和基因型与候选患者类似的患者群; 根据每个候选患者队列中患者的历史治疗信息，评估患者队列，以确定与候选患者最佳匹配的队列; 从多个队列中选择一个队列; 并根据选择向患者或护理提供者提供治疗建议。