公开(公告)号：US20210161934A1

公开(公告)日：2021-06-03

申请号：US17154192

申请日：2021-01-21

申请人： H. Lee Moffitt Cancer Center and Research Institute, Inc. ,  The University of Miami Leonard M. Miller School of Medicine

发明人： James Mulé ,  Rana Falahat ,  Glen Barber

IPC分类号： A61K31/7068 ,  A61K35/17 ,  A61K31/7084 ,  A61P35/00 ,  C12N5/0783 ,  G01N33/574

摘要： Disclosed herein is a method for enhancing antitumor T cell responses in subjects. The method involves administering to the subject in need thereof a composition comprising a demethylating agent in an amount effective to demethylate STING proteins in the tumor cells. This method is particularly useful in subjects with deficient STING expression in the tumor cells. Therefore, also disclosed is a method for treating a tumor in a subject that involves detecting in a biopsy sample from the subject reduced STING expression, reduced cGAS expression, or a combination thereof; and then administering to the subject a demethylating agent in an amount effective to demethylate STING proteins in the tumor cells. The method can further involve administering to the subject a therapeutically effective amount of a STING agonist. The method can further involve administering to the subject tumor infiltrating lymphocytes (TILs), such as HLA-matched TILs.

公开(公告)号：US20210220441A1

公开(公告)日：2021-07-22

申请号：US17052973

申请日：2019-05-08

申请人： h. Lee Moffitt Cancer Center and Research Institute, Inc.

发明人： James Mulé ,  Rana Falahat ,  Genyuan Zhu

IPC分类号： A61K38/19 ,  A61K9/00 ,  A61K35/26 ,  A61K47/36

摘要： As disclosed herein, stromal cells are important for the recruitment and organization of lymphocytes in TLSs. Therefore, disclosed herein are composition and methods for bioengineering TLSs in animals, such as mice. These compositions involve chemokine-releasing microparticles or cells that can be implanted into the animals. Therefore, disclosed herein are chitosan hydrogels with chemokine releasing microparticles or cells.