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    Benzofuran derivatives, their preparation and use
    3.
    发明申请
    Benzofuran derivatives, their preparation and use 失效
    苯并呋喃衍生物，其制备和用途

    公开(公告)号：US20020032205A1

    公开(公告)日：2002-03-14

    申请号：US09874392

    申请日：2001-06-04

    Applicant: H. Lundbeck A/S

    Inventor： Kim Andersen ,  Mario Rottlander ,  Klaus Peter Bogeso ,  Henrik Pedersen ,  Thomas Ruhland ,  Robert Dancer

    IPC: A61K031/496 ,  C07D49/02 ,  A61K031/4525 ,  A61K031/352

    CPC classification number: C07D307/87 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D471/04

    Abstract: The present invention relates to benzofuran derivatives having general Formula (I) 1 wherein A is selected from (1), (2), (3), (4) 2 wherein Z is O or S; s is 0 or 1; q is 0 or 1; R4 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C26-alkynyl, C1-6-alkyl-aryl, or C1-6-alkyl-O-aryl; D is a spacer group selected from branched or straight chain C1-6-alkylene, C2-6-alkenylene and C2-6-alkynylene; its enantiomers, and pharmaceutically acceptable acid addition salt thereof. The compounds are potently binding to the 5-HT1A receptor.

    Abstract translation: 本发明涉及通式（I）的苯并呋喃衍生物，其中A选自（1），（2），（3），（4）其中Z为O或S; s为0或1; q为0或1; R 4是氢，C 1-6 - 烷基，C 2-6烯基，C 2-6炔基，C 1-6 - 烷基 - 芳基或C 1-6 - 烷基-O-芳基; D是选自支链或直链C 1-6 - 亚烷基，C 2-6亚烯基和C 2-6亚炔基的间隔基; 其对映体及其药学上可接受的酸加成盐。 这些化合物与5-HT1A受体有很强的结合。

    Indane or dihydroindole derivatives
    4.
    发明申请
    Indane or dihydroindole derivatives 失效
    茚满或二氢吲哚衍生物

    公开(公告)号：US20010051625A1

    公开(公告)日：2001-12-13

    申请号：US09915680

    申请日：2001-07-26

    Applicant: H. Lundbeck A/S

    Inventor： Jens Kristian Perregaard ,  Ivan Mikkelsen ,  Henrik Pedersen

    IPC: A61K031/496 ,  C07D413/14 ,  A61K031/454

    CPC classification number: C07D405/12 ,  C07D317/66

    Abstract: The present invention relates to substituted indane or dihydroindole compounds of 1 Formula (I), wherein A and B are independently O or S; D is an optionally substituted methylene group; X is N or optionally substituted C; and W is a spacer group. The compounds are either selective dopamine D4 ligands or they have combined effects at dopamine D4 and serotonergic receptors and/or the serotonergic transporter. These compounds are therefore useful in the treatment of certain psychiatric and neurologic disorders, including psychosis, depression and anxiety.

    Abstract translation: 本发明涉及式（I）的取代的茚满或二氢吲哚化合物，其中A和B独立地为O或S; D是任选取代的亚甲基; X为N或任选取代的C; W是间隔基。 这些化合物是选择性多巴胺D4配体，或它们在多巴胺D4和5-羟色胺能受体和/或血清素能转运体上具有组合效应。 因此，这些化合物可用于治疗某些精神和神经障碍，包括精神病，抑郁和焦虑。

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