公开(公告)号：US20140296525A1

公开(公告)日：2014-10-02

申请号：US14294707

申请日：2012-12-06

Applicant: H. Lundbeck A/S

Inventor： Carla De Faveri ,  Mariano Stivanello

IPC: C07D489/08

CPC classification number: C07D489/08 ,  A61K31/485

Abstract: The present invention relates to an improved process for recovery of nalmefene hydrochloride [17-(cyclopropylmethyl)-4,5- alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride] from an aqueous composition containing nalmefene and certain impurities.

Abstract translation: 本发明涉及从含有纳美芬和某些杂质的含水组合物中回收盐酸纳美芬[17-（环丙基甲基）-4,5-α-环氧-6-亚甲基吗啡喃-3,14-二醇盐酸盐]的改进方法。

公开(公告)号：US20210147366A1

公开(公告)日：2021-05-20

申请号：US17045045

申请日：2019-04-05

Applicant: H. Lundbeck A/S

Inventor： Carla De Faveri ,  Florian Anton Martin Huber ,  Mariano Stivanello

IPC: C07D241/04 ,  B01J23/44

Abstract: This invention relates to a novel chemical process for the synthesis of 2,2-dimethylpiperazine and the further transformation of 2,2-dimethylpiperazine into ferf-butyl-3,3-dimethylpiperazine-1-carboxylate-hemi-DL-tartrate.

公开(公告)号：US08841452B1

公开(公告)日：2014-09-23

申请号：US14294707

申请日：2012-12-06

Applicant: H. Lundbeck A/S

Inventor： Carla De Faveri ,  Mariano Stivanello

IPC: C07D489/08 ,  C07D489/02

CPC classification number: C07D489/08 ,  A61K31/485

Abstract: The present invention relates to an improved process for recovery of nalmefene hydrochloride[17-(cyclopropylmethyl)-4,5-alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride] from an aqueous composition containing nalmefene and certain impurities.

Abstract translation: 本发明涉及从含有纳美芬和某些杂质的含水组合物中回收盐酸纳美芬[17-（环丙基甲基）-4,5-α-环氧-6-亚甲基吗啡喃-3,14-二醇盐酸盐]的改进方法。