公开(公告)号：US10022303B2

公开(公告)日：2018-07-17

申请号：US13781115

申请日：2013-02-28

申请人： H. William Bosch ,  Matthew Callahan ,  Felix Meiser ,  Marck Norret ,  Adrian Russell

发明人： H. William Bosch ,  Matthew Callahan ,  Felix Meiser ,  Marck Norret ,  Adrian Russell

IPC分类号： A61K9/00 ,  A61K31/00 ,  A61J3/02 ,  A61K31/137 ,  A61K31/46

摘要： Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm are described.

公开(公告)号：US20140065219A1

公开(公告)日：2014-03-06

申请号：US13781115

申请日：2013-02-28

申请人： William H. Bosch ,  Matthew Callahan ,  Felix Meiser ,  Marck Norret ,  Adrian Russell

发明人： William H. Bosch ,  Matthew Callahan ,  Felix Meiser ,  Marck Norret ,  Adrian Russell

IPC分类号： A61J3/02

CPC分类号： A61J3/02 ,  A61K9/0075 ,  A61K31/137 ,  A61K31/46 ,  A61K2300/00

摘要： Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm are described.

摘要翻译： 制备包含药物活性剂的可吸入复合颗粒的方法，所述方法包括：a）提供包含可研磨基质和固体药物活性剂的复合颗粒，其中所述药物活性剂具有体积平均值的中值粒度 基础在50nm和3um之间; 并且b）在不研磨体的研磨机中研磨复合颗粒足以产生质量中值空气动力学直径在1m和20μm之间的可吸入复合颗粒的时间段。