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公开(公告)号：US08735450B2
公开(公告)日：2014-05-27
申请号：US13266122
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A61K31/196 , A61K9/14 , C07C229/42 , B82Y40/00
CPC分类号： A61K31/196 , A61K9/0053 , A61K9/0087 , A61K9/14 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/16 , A61K9/1682 , A61K9/4808 , A61K9/4825 , A61K9/4858 , A61K9/5115 , A61K9/5123 , A61K9/513 , A61K9/5138 , A61K9/5192 , A61K47/12 , A61K47/20 , Y02A50/465 , Y10T428/2982
摘要： The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac, medicaments produced using diclofenac in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of diclofenac administered by way of said medicaments.
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公开(公告)号：US20120263760A1
公开(公告)日：2012-10-18
申请号：US13266115
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H. William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H. William Bosch
IPC分类号： A61K31/421 , A61P25/04 , B32B5/16 , A61K9/00
CPC分类号： C07D263/20 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1694 , A61K31/421 , Y10T428/2978
摘要： The present invention relates to methods for producing particles of metaxalone using dry milling processes as well as compositions comprising metaxalone, medicaments produced using metaxalone in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of metaxalone administered by way of said medicaments.
摘要翻译： 本发明涉及使用干研磨方法生产美他沙酮颗粒的方法以及包含美他沙酮，以颗粒形式和/或组合物使用美他沙酮制备的药物的组合物，以及使用治疗有效的方法治疗动物，包括人的方法 通过所述药物施用的美他沙酮的量。
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公开(公告)号：US20120165410A1
公开(公告)日：2012-06-28
申请号：US13265914
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A61K31/192 , A61P29/00
摘要： The present invention relates to methods for producing particles of a biologically active material using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产生物活性物质的颗粒的方法以及包含这些材料的组合物，使用所述生物活性材料以颗粒形式和/或组合物制备的药物，以及治疗动物的方法， 包括使用治疗有效量的通过所述药物施用的所述生物活性物质的人。
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4.发明申请METHOD FOR IMPROVING THE DISSOLUTION PROFILE OF A BIOLOGICALLY ACTIVE MATERIAL 审中-公开改善生物活性材料溶解度特征的方法公开(公告)号：US20120165323A1
公开(公告)日：2012-06-28
申请号：US13265927
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch , Matt Callahan
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch , Matt Callahan
IPC分类号： A61K31/5415 , A61K31/196
CPC分类号： A61K9/1682 , A01N25/14 , A61K9/145 , A61K9/146 , A61K31/137 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/415 , A61K31/421 , A61K31/496 , A61K31/5415
摘要： The present invention relates to a method for improving the dissolution profile of a biologically active material comprising the steps of dry milling a solid biologically active material and a millable grinding matrix in a mill comprising a plurality of milling bodies, for a time period sufficient to produce particles of the biologically active material dispersed in an at least partially milled grinding material.
摘要翻译： 本发明涉及一种用于改善生物活性材料的溶出曲线的方法，包括以下步骤：在包含多个研磨体的研磨机中将固体生物活性材料和可研磨基质干磨，时间足以产生 分散在至少部分磨碎的研磨材料中的生物活性材料的颗粒。
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公开(公告)号：US20120148634A1
公开(公告)日：2012-06-14
申请号：US13266119
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A61K9/14 , B32B5/16 , A61P25/04 , A61K31/192 , A61P25/00
CPC分类号： A61K31/192 , A61J3/02 , A61K9/14 , A61K9/141 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1682 , Y02A50/465 , Y10T428/2982
摘要： The present invention relates to methods for producing particles of naproxen using dry milling processes as well as compositions comprising naproxen, medicaments produced using naproxen in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of naproxen administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产萘普生颗粒的方法以及包含萘普生的组合物，使用纳豆酮颗粒形式和/或组合物制备的药物，以及使用治疗有效的方法治疗动物（包括人）的方法 通过所述药物施用萘普生的量。
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公开(公告)号：US20120141548A1
公开(公告)日：2012-06-07
申请号：US13266118
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosvch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosvch
IPC分类号： A61K31/5415 , A61P25/04 , B32B5/16 , A61K9/14
CPC分类号： C07D417/12 , A61K9/14 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/5115 , A61K9/5123 , A61K9/513 , A61K31/5415 , B02C23/06 , B63B22/026 , B63B27/34 , B63B2035/442 , B63B2035/448 , B65H75/38 , B65H75/4402 , B65H75/4415 , B65H75/4486 , B65H2701/33 , B67D9/00 , Y02A50/465 , Y10T428/2982
摘要： The present invention relates to methods for producing particles of meloxicam using dry milling processes as well as compositions comprising meloxicam, medicaments produced using meloxicam in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of meloxicam administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产美洛昔康颗粒的方法以及包含美洛昔康的组合物，使用颗粒形式和/或组合物的美洛昔康制备的药物以及使用治疗有效的方法治疗动物（包括人）的方法 通过所述药物施用的美洛昔康的量。
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公开(公告)号：US20140065219A1
公开(公告)日：2014-03-06
申请号：US13781115
申请日：2013-02-28
IPC分类号： A61J3/02
CPC分类号： A61J3/02 , A61K9/0075 , A61K31/137 , A61K31/46 , A61K2300/00
摘要： Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm are described.
摘要翻译： 制备包含药物活性剂的可吸入复合颗粒的方法，所述方法包括：a）提供包含可研磨基质和固体药物活性剂的复合颗粒，其中所述药物活性剂具有体积平均值的中值粒度 基础在50nm和3um之间; 并且b）在不研磨体的研磨机中研磨复合颗粒足以产生质量中值空气动力学直径在1m和20μm之间的可吸入复合颗粒的时间段。
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公开(公告)号：US20120135047A1
公开(公告)日：2012-05-31
申请号：US13266122
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A61K31/196 , C07C229/42 , A61K9/14 , B82Y40/00 , B82Y5/00
CPC分类号： A61K31/196 , A61K9/0053 , A61K9/0087 , A61K9/14 , A61K9/141 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/16 , A61K9/1682 , A61K9/4808 , A61K9/4825 , A61K9/4858 , A61K9/5115 , A61K9/5123 , A61K9/513 , A61K9/5138 , A61K9/5192 , A61K47/12 , A61K47/20 , Y02A50/465 , Y10T428/2982
摘要： The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac, medicaments produced using diclofenac in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of diclofenac administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产双氯芬酸颗粒的方法以及包含双氯芬酸的组合物，使用颗粒形式的双氯芬酸和/或组合物制备的药物，以及使用治疗有效的方法治疗动物，包括人的方法 通过所述药物施用的双氯芬酸的量。
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公开(公告)号：US10022303B2
公开(公告)日：2018-07-17
申请号：US13781115
申请日：2013-02-28
IPC分类号： A61K9/00 , A61K31/00 , A61J3/02 , A61K31/137 , A61K31/46
摘要： Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm are described.
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公开(公告)号：US20120202694A1
公开(公告)日：2012-08-09
申请号：US13265936
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H William Bosch
IPC分类号： A01N57/20 , A61K31/192 , A61K31/5415 , A61K31/405 , A23F5/08 , A61K31/635 , A61K31/196 , A61K31/421 , A01P13/00 , A23G1/02 , A61K31/137 , A61K31/496
CPC分类号： B02C17/10 , A01N25/34 , A01N39/04 , A01N47/10 , A01N57/20 , A23P10/30 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K31/137 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/415 , A61K31/421 , A61K31/496 , A61K31/5415
摘要： The present invention relates to methods for producing particles of a biologically active material using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments.
摘要翻译： 本发明涉及使用干磨法生产生物活性物质的颗粒的方法以及包含这些材料的组合物，使用所述生物活性材料以颗粒形式和/或组合物制备的药物，以及治疗动物的方法， 包括使用治疗有效量的通过所述药物施用的所述生物活性物质的人。
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