公开(公告)号：US12065509B2

公开(公告)日：2024-08-20

申请号：US17520141

申请日：2021-11-05

申请人： HD IMMUNE GMBH

发明人： Oskar Smrzka ,  Stefan Bartl ,  Michela Parth

IPC分类号： C07K17/02 ,  C07K16/18 ,  G01N33/577 ,  G01N33/68

CPC分类号： C07K17/02 ,  C07K16/18 ,  G01N33/577 ,  G01N33/6896 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  G01N2800/2835

摘要： A monoclonal antibody may have a binding domain that binds to a peptide of the HTT protein having the sequence of p7543 (SEQ ID No. 3). Such a monoclonal according may include a heavy chain variable region CDR1 comprising GYTFTEYT (SEQ ID No. 66), a heavy chain variable region CDR2 comprising INPNNGGT (SEQ ID No. 67), a heavy chain variable region CDR3 comprising ASLDGRDY (SEQ ID No. 68), a light chain variable region CDR1 comprising QSLLNSRTRKNY (SEQ ID No. 69), a light chain variable region CDR2 comprising WAS (SEQ ID No. 70), and/or a light chain variable region comprising KQSYNLLT (SEQ ID No. 71).