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    APOLIPOPROTEIN NANODISCS WITH TELODENDRIMER
    1.
    发明公开
    APOLIPOPROTEIN NANODISCS WITH TELODENDRIMER 审中-公开

    公开(公告)号：US20230416414A1

    公开(公告)日：2023-12-28

    申请号：US18334034

    申请日：2023-06-13

    申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

    发明人： Juntao LUO ,  Wei HE ,  Kit S. LAM ,  Paul HENDERSON ,  Matthew A. COLEMAN

    IPC分类号： C07K17/02 ,  C07K14/775

    CPC分类号： C07K17/02 ,  C07K14/775

    摘要： The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

    APOLIPOPROTEIN NANODISCS WITH TELODENDRIMER
    5.
    发明申请
    APOLIPOPROTEIN NANODISCS WITH TELODENDRIMER 审中-公开

    公开(公告)号：US20180079829A1

    公开(公告)日：2018-03-22

    申请号：US15499855

    申请日：2017-04-27

    申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

    发明人： Juntao LUO ,  Wei HE ,  Kit S. LAM ,  Paul HENDERSON ,  Matthew A. COLEMAN

    IPC分类号： C07K17/02 ,  C07K14/775

    CPC分类号： C07K17/02 ,  C07K14/775

    摘要： The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a polyethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

    Method for selecting a candidate drug compound
    10.
    发明授权
    Method for selecting a candidate drug compound 有权
    选择候选药物化合物的方法

    公开(公告)号：US09176127B2

    公开(公告)日：2015-11-03

    申请号：US14201523

    申请日：2014-03-07

    申请人： PEPSCAN SYSTEMS B.V.

    发明人： Peter Timmerman ,  Joris Beld ,  Robbert H. Meloen ,  Wouter C. Puijk

    IPC分类号： C40B40/10 ,  C07K7/64 ,  C07K17/06 ,  G01N33/543 ,  C40B30/04 ,  C07K17/02

    CPC分类号： G01N33/54306 ,  C07K17/02 ,  C40B30/04 ,  G01N33/54353

    摘要： The disclosure relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule capable of reacting with the at least first and second reactive group; contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the at least one molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage, preferably wherein the coupling reaction is performed in solution, more preferably in an aqueous solution. Furthermore, a method is provided for selecting a candidate drug compound comprising providing a library of compounds hereof and determining the binding of a target molecule to the compounds.

    摘要翻译： 本公开涉及候选药物检测和药物开发领域。 提供了一种提供由至少一个分子通过至少两个键连接到分子支架构成的化合物的方法，所述方法包括提供包含至少第一和第二反应性基团的支架; 提供至少一个能够与至少第一和第二反应性基团反应的分子; 使所述支架与至少一个分子接触以在偶联反应中在所述支架和所述至少一个分子之间形成至少两个键，其中所述连接的形成加速连续键的形成，优选地其中所述偶联反应在 溶液，更优选在水溶液中。 此外，提供了选择候选药物化合物的方法，其包括提供本文化合物文库并确定靶分子与化合物的结合。