公开(公告)号：US20240307430A1

公开(公告)日：2024-09-19

申请号：US18671968

申请日：2024-05-22

Applicant: HEFEI KNATURE BIO-PHARM CO., LTD.

Inventor： Junbo GE ,  Aijun SUN ,  Wei LUO ,  Wei WANG ,  Kanglin WANG ,  Lei WANG ,  Beijian ZHANG ,  Zheng DONG ,  Xinyu WENG ,  Yongchao ZHAO

IPC: A61K31/7084 ,  A61K31/4709 ,  A61P9/00

CPC classification number: A61K31/7084 ,  A61K31/4709 ,  A61P9/00

Abstract: A pharmaceutical composition, including nicotinamide adenine dinucleotide (NAD) and a CD38 inhibitor in a weight ratio of 1-5:5-1, where the CD38 inhibitor is compound 78c. A pharmaceutical preparation including the pharmaceutical composition and an application of the pharmaceutical composition in the prevention and/or treatment of doxorubicin-induced cardiotoxicity are further provided.

公开(公告)号：US20210371843A1

公开(公告)日：2021-12-02

申请号：US17256364

申请日：2020-06-11

Applicant: HEFEI KNATURE BIO-PHARM CO., LTD.

Inventor： Wei WANG ,  Kanglin WANG ,  Minjie FU ,  Yonghong JIN ,  Feng TIAN ,  Heping JIA ,  Zhihao HU

IPC: C12N9/78 ,  C12N9/10 ,  C12N9/12 ,  C12N9/00 ,  C12P19/36

Abstract: The invention discloses a genetically engineered bacterium in which the gene encoding adenine deaminase on the genome of the bacterium is knocked out or/and the gene encoding the enzyme in the NAD+ anabolic pathway is integrated on the genome of the bacterium. The invention also discloses a construction method of the above-mentioned genetically engineered bacteria. The gene encoding adenine deaminase on the genome of the host strain is knocked out to obtain a strain with high NAD+ yield. Or the expression cassettes of the gene encoding the enzyme in the NAD+ synthesis pathway are constructed separately, and then the enzyme encoding The gene expression cassette is integrated into the genome of the host strain whose gene encoding adenine deaminase is knocked out to construct a strain with high NAD+ production. The application of the above genetically engineered bacteria is disclosed. A method of producing NAD+ is disclosed.