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公开(公告)号：US09872883B2
公开(公告)日：2018-01-23
申请号：US15135147
申请日：2016-04-21
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor De Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： C07D401/06 , C07D401/12 , A61K31/445 , A61K38/05 , C07K5/062 , A61K9/16
CPC分类号： A61K38/05 , A61K9/1682 , C07D401/06 , C07D401/12 , C07K5/06034
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
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公开(公告)号：US20160235804A1
公开(公告)日：2016-08-18
申请号：US15135147
申请日：2016-04-21
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor De Groot , Silvina Garcia Rubio , Peter Manini
CPC分类号： A61K38/05 , A61K9/1682 , C07D401/06 , C07D401/12 , C07K5/06034
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
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3.发明申请METHODS OF PRODUCING ANAMORELIN HYDROCHLORIDE HAVING CONTROLLED CHLORIDE CONTENT 有权生产具有氯化物控制含量的阿诺霉素盐酸盐的方法公开(公告)号：US20150072934A1
公开(公告)日：2015-03-12
申请号：US14539318
申请日：2014-11-12
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Marcia Philipson , Eleanor De Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： C07K5/062
CPC分类号： A61K38/05 , A61K9/1682 , C07D401/06 , C07D401/12 , C07K5/06034
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
摘要翻译： 本发明涉及异山梨醇一盐酸盐的颗粒形式或包含具有受控氯化物含量的阿莫瑞林一盐酸盐的组合物，优选以无定形和/或细颗粒状态分离，制备颗粒形式的方法和包含颗粒形式的药物组合物。
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公开(公告)号：US09956261B2
公开(公告)日：2018-05-01
申请号：US15135107
申请日：2016-04-21
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor De Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： C07D401/12 , A61K38/05 , C07D401/06 , C07K5/062 , A61K9/16
CPC分类号： A61K38/05 , A61K9/1682 , C07D401/06 , C07D401/12 , C07K5/06034
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
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公开(公告)号：US20160237115A1
公开(公告)日：2016-08-18
申请号：US15135107
申请日：2016-04-21
发明人： Shin-itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor De Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： C07K5/062
CPC分类号： A61K38/05 , A61K9/1682 , C07D401/06 , C07D401/12 , C07K5/06034
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
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6.发明授权Methods of producing anamorelin hydrochloride having controlled chloride content 有权生产具有受控氯化物含量的盐酸阿莫瑞林的方法公开(公告)号：US09403867B2
公开(公告)日：2016-08-02
申请号：US14539318
申请日：2014-11-12
发明人： Shin-Itsu Kuwabe , Takehiko Yanagimachi , Hideyuki Yoshiyama , Seemon Pines , Eleanor De Groot , Silvina Garcia Rubio , Peter Manini
IPC分类号： C07D401/06 , A61K31/445 , C07K5/062 , C07D401/12
CPC分类号： A61K38/05 , A61K9/1682 , C07D401/06 , C07D401/12 , C07K5/06034
摘要： The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled chloride content, preferably isolated in an amorphous and/or fine particulate state, processes for making the particulate forms, and pharmaceutical compositions comprising the particulate forms.
摘要翻译： 本发明涉及异山梨醇一盐酸盐的颗粒形式或包含具有受控氯化物含量的阿莫瑞林一盐酸盐的组合物，优选以无定形和/或细颗粒状态分离，制备颗粒形式的方法和包含颗粒形式的药物组合物。
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公开(公告)号：US20220323430A1
公开(公告)日：2022-10-13
申请号：US17634616
申请日：2020-08-28
发明人： Koji Taniguchi , Kaori Iida , Asuka Hayashi , Eleanor De Groot
IPC分类号： A61K31/454 , A61K9/20
摘要： Methods for reducing the formation of impurities in finished dosage forms of anamorelin hydrochloride, including formulations for improving such stability and analytical techniques for controlling impurity formation.
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