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    ENZYMATIC SAMPLE PURIFICATION
    3.
    发明申请
    ENZYMATIC SAMPLE PURIFICATION 审中-公开

    公开(公告)号：US20190003937A1

    公开(公告)日：2019-01-03

    申请号：US15770456

    申请日：2016-02-29

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Viktor SHKOLNIKOV ,  Anita ROGACS

    IPC: G01N1/40 ,  C12Q1/37

    Abstract: An enzymatic purification method involves the introduction of a sample comprising a target analyte and amino acids into a porous matrix of a reaction chamber. The reaction chamber includes first pores and second pores. The first pores contain polypeptide synthesis enzymes that react with the amino acids to form polypeptides. First pores having a first size to be accessible by amino acids but inaccessible by the subsequently formed polypeptides. The second pores have a second size greater than the first size, are in contact with the first pores and form a series extending from within the reaction chamber to a waste chamber. The formed polypeptides are migrated through the series of second pores to the waste chamber. The target analyte of the sample is extracted from the reaction chamber.

    ENZYMATIC SAMPLE PURIFICATION
    5.
    发明申请
    ENZYMATIC SAMPLE PURIFICATION 有权

    公开(公告)号：US20220280942A1

    公开(公告)日：2022-09-08

    申请号：US17752394

    申请日：2022-05-24

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Viktor Shkolnikov ,  Anita ROGACS

    IPC: B01L3/00 ,  G01N1/34 ,  C07K1/34 ,  B01L7/00

    Abstract: An apparatus of an enzymatic sample purifier can include a reaction chamber containing a polypeptide synthesizing enzyme capable of reacting with a protein degradation product to form polypeptides having a size of at least 1,000 Da and including the protein degradation product, the reaction chamber having a port configured to receive a fluid sample including a target analyte having a size of no greater than 500 Da and the protein degradation product. The apparatus can also include a product chamber, an electrophoretic transport mechanism to move a purified portion of the fluid sample including the target analyte to the product chamber, and a separator positioned to retain the formed polypeptides resulting from reaction of the protein degradation product with the polypeptide synthesizing enzyme in the reaction chamber and to pass the target analyte to the product chamber, wherein the separator comprises a porous matrix.

    ENZYMATIC SAMPLE PURIFICATION
    7.
    发明申请
    ENZYMATIC SAMPLE PURIFICATION 审中-公开

    公开(公告)号：US20190056299A1

    公开(公告)日：2019-02-21

    申请号：US15770479

    申请日：2016-02-29

    Applicant: Hewlett-Packard Development Company , L.P.

    Inventor： Viktor SHKOLNIKOV ,  Anita ROGACS

    IPC: G01N1/40 ,  C12Q1/37 ,  G01N1/34

    Abstract: An enzymatic sample purifier comprises a reaction chamber containing an enzyme, a product chamber and a separator. The reaction chamber has a port to receive a sample comprising a protein degradation product. The separator retains polypeptides resulting from reaction of the protein degradation product with the enzyme in the reaction chamber and facilitates transport of purified remaining portions of the sample comprising a target analyte to the product chamber.

    TARGET CLASS FEATURE MODEL
    10.
    发明申请
    TARGET CLASS FEATURE MODEL 审中-公开

    公开(公告)号：US20190034518A1

    公开(公告)日：2019-01-31

    申请号：US16074704

    申请日：2016-10-28

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： Lei LIU ,  Anita ROGACS

    IPC: G06F17/30

    Abstract: A method may include sensing first data samples from a first set of different subjects having a membership in a target class and sensing second data samples from a second set of different subjects not having a membership in the target class, wherein each of the first data samples and the second data samples includes a composite of individual data features. The individual data features from each composite of the first data samples and the second data samples are extracted and quantified. Sets of features and associated weightings of a target class model are identified based upon quantified values of the individual features from each composite of the first samples and the second samples to create a model representing a fingerprint of the target class to determine membership status of a sample having an unknown membership status with respect to the target class.

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