公开(公告)号：US20170224630A1

公开(公告)日：2017-08-10

申请号：US15518847

申请日：2015-10-13

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Junji NOGUCHI ,  Eisuke HATANAKA ,  Hisakazu KURITA ,  Ryusuke FUDOJI ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K47/06 ,  C08F226/10 ,  C09J7/02 ,  A61K31/00 ,  C08F226/02 ,  C08K5/092

CPC classification number: A61K9/7053 ,  A61K9/7061 ,  A61K31/00 ,  A61K31/485 ,  A61K47/06 ,  A61K47/10 ,  C08F226/02 ,  C08F226/10 ,  C08K5/092

Abstract: A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

公开(公告)号：US20210244925A1

公开(公告)日：2021-08-12

申请号：US16973553

申请日：2019-07-11

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Eisuke HATANAKA ,  Kazuki KURIYAMA ,  Naoki YAMAMOTO

IPC: A61M37/00

Abstract: A method of producing a microneedle sheet according to an embodiment includes: preparing a sheet having a first surface and a second surface; making a first cut in a range from the first surface to the second surface of the sheet to form a first outer edge that defines a tip end of the microneedle; and making, after forming the first outer edge, a second cut in a range from the first surface to the second surface of the sheet to form a second outer edge that defines the tip end of the microneedle, thereby forming the tip end of the microneedle.