公开(公告)号：US20200316355A1

公开(公告)日：2020-10-08

申请号：US16767290

申请日：2018-11-06

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takuya TAJIMA ,  Naoki YAMAMOTO ,  Seiji TOKUMOTO

IPC: A61M37/00

Abstract: An application kit according to one embodiment includes: a cartridge including a sheet member; and an applicator being connectable to the cartridge. The cartridge includes a bending portion configured to bend the sheet member and a cartridge-side connector configured to be detachably connected to the applicator. The applicator includes: an applicator body; an applicator-side connector provided to a bottom portion of the applicator body; a cap provided above the applicator body and being movable along a height direction of the applicator body; and an elastic member extending along the height direction between the applicator body and the cap and configured to apply, to the cap, an elastic force that acts in a direction away from the bottom portion.

公开(公告)号：US20170333690A1

公开(公告)日：2017-11-23

申请号：US15532836

申请日：2015-12-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Makoto OGURA ,  Naoki YAMAMOTO ,  Takashi KUMON

IPC: A61M37/00

Abstract: A microneedle device system includes a microneedle device having a sheet-like microneedle having a sheet in which one surface is a skin contact surface and the other surface is a rear surface, and in which a plurality of microneedles are formed substantially along a surface of the sheet, and in which the microneedles in the skin piercing region are raised from the skin contact surface so as to be capable of piercing skin if the sheet is bent in a thickness direction, an adhesive layer that is disposed on the sheet-like microneedle, and a liner that is attached to the adhesive layer so as to be releasable therefrom, and an auxiliary tool having a bending portion which bends the microneedle device in the thickness direction, and on which the microneedle device is mounted so as to be movable along the bending portion.

公开(公告)号：US20190009070A1

公开(公告)日：2019-01-10

申请号：US16061834

申请日：2016-12-06

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryusuke FUDOJI ,  Naoki YAMAMOTO

IPC: A61M37/00 ,  C08L67/04

Abstract: The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.

公开(公告)号：US20160144160A1

公开(公告)日：2016-05-26

申请号：US14899148

申请日：2014-06-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Makoto OGURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023

Abstract: An applicator of one aspect for applying microneedles to skin includes a resistive portion configured to apply resistance against movement of a microneedle sheet having the plurality of microneedles formed along a main surface of the sheet, and a bending portion configured to bend the microneedle sheet passed through the resistive portion to raise the microneedle from the main surface.

Abstract translation: 用于将微针施加到皮肤的一个方面的涂抹器包括电阻部分，其被构造成施加抵抗沿着所述片材的主表面形成的具有多个微针的微针片的运动的阻力;以及弯曲部分，其被配置为弯曲经过的微针片 电阻部分，用于将微针从主表面上升。

公开(公告)号：US20160136405A1

公开(公告)日：2016-05-19

申请号：US14899146

申请日：2014-06-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Makoto OGURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M25/002 ,  A61M35/00 ,  A61M37/00 ,  A61M2025/0266 ,  A61M2037/0023

Abstract: An applicator of one aspect for applying a sheet member to skin includes a body having a bottom surface facing the skin and a first guide configured to guide the sheet member to a space between the skin and the bottom surface, in which the sheet member is applied to the skin after being folded in the space.

Abstract translation: 用于将片材构件施加到皮肤的一个方面的施加器包括具有面向皮肤的底表面的主体和被构造成将片材引导到皮肤和底表面之间的空间的第一引导件，其中应用片材构件 在空间中折叠后的皮肤。

公开(公告)号：US20190388668A1

公开(公告)日：2019-12-26

申请号：US16471290

申请日：2017-12-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takuya TAJIMA ,  Naoki YAMAMOTO ,  Seiji TOKUMOTO

IPC: A61M37/00

Abstract: An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.

公开(公告)号：US20240269446A1

公开(公告)日：2024-08-15

申请号：US17766434

申请日：2020-09-14

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Shinpei NISHIMURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: A microneedle sheet according to one embodiment includes: a sheet body having a main surface; and at least one microneedle formed on the sheet body and lying along the main surface. Each of the at least one microneedle has a base positioned on a first side of the sheet body and a tip oriented toward a second side of the sheet body that is opposite to the first side. A first portion of the sheet body is bent from the first side, whereby the microneedle positioned in the first portion is raised from the main surface and the raised microneedle is applied to skin.

公开(公告)号：US20210244925A1

公开(公告)日：2021-08-12

申请号：US16973553

申请日：2019-07-11

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Eisuke HATANAKA ,  Kazuki KURIYAMA ,  Naoki YAMAMOTO

IPC: A61M37/00

Abstract: A method of producing a microneedle sheet according to an embodiment includes: preparing a sheet having a first surface and a second surface; making a first cut in a range from the first surface to the second surface of the sheet to form a first outer edge that defines a tip end of the microneedle; and making, after forming the first outer edge, a second cut in a range from the first surface to the second surface of the sheet to form a second outer edge that defines the tip end of the microneedle, thereby forming the tip end of the microneedle.

公开(公告)号：US20190201676A1

公开(公告)日：2019-07-04

申请号：US16325325

申请日：2017-08-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Seiji TOKUMOTO

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61K9/00 ,  A61K47/36 ,  A61M37/00 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053

Abstract: A microneedle sheet is disclosed that comprises a plurality of microneedles formed on a sheet generally along a principal surface of the sheet, wherein the microneedles contain a water-soluble polysaccharide and water, the water content is 1 mass % or more and less than 19 mass % based on the total mass of the microneedles, and the microneedles are raised from the principal surface by bending the sheet.

公开(公告)号：US20190046779A1

公开(公告)日：2019-02-14

申请号：US16078784

申请日：2017-02-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takuya TAJIMA ,  Naoki YAMAMOTO ,  Kazuki KURIYAMA ,  Seiji TOKUMOTO

IPC: A61M37/00

Abstract: An applicator according to one embodiment is an applicator for applying a sheet member to skin, and includes: a bottom plate facing the skin; a top plate facing the bottom plate and configured to be pressed toward the bottom plate; and a bending portion configured to apply the sheet member to the skin by bending the sheet member having advanced thereto in a pressed state in which the top plate has been moved toward the bottom plate.