公开(公告)号：US20180140704A1

公开(公告)日：2018-05-24

申请号：US15568432

申请日：2016-04-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kana IMAMURA ,  Tomohiro SHINODA ,  Shingo SOMEKAWA ,  Yasunari MICHINAKA

IPC: A61K47/12 ,  A61K9/00 ,  A61P17/00 ,  A61K31/216

Abstract: The present invention provides a topical preparation for treating hyperhidrosis, comprising water, an anticholinergic drug, and one or more salts selected from the group consisting of lactate, tartrate, acetate and phosphate. Such a topical preparation comprises the above certain salt, thereby facilitating the accumulation of the anticholinergic drug in skin appendages.

公开(公告)号：US20210251913A1

公开(公告)日：2021-08-19

申请号：US17244552

申请日：2021-04-29

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo TANAKA ,  Hideaki OHASHI ,  Naruhide MIYOSHI ,  Takito SHIMA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US20190350874A1

公开(公告)日：2019-11-21

申请号：US16474213

申请日：2017-12-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo TANAKA ,  Hideaki OHASHI ,  Naruhide MIYOSHI ,  Takito SHIMA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US20160354322A1

公开(公告)日：2016-12-08

申请号：US15114979

申请日：2015-01-28

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yasunari MICHINAKA ,  Tomohiro SHINODA ,  Kana IMAMURA

IPC: A61K9/70 ,  A61K47/18 ,  A61K31/551

CPC classification number: A61K9/7053 ,  A61K9/70 ,  A61K9/703 ,  A61K31/551 ,  A61K47/18 ,  A61K47/32 ,  A61K47/34

Abstract: Provided is an emedastine-containing tape preparation comprising a support film, and a pressure-sensitive adhesive layer laminated on the support film, wherein the pressure-sensitive adhesive layer comprises emedastine, a fumarate salt of an organic amine, and a pressure-sensitive adhesive.

Abstract translation: 本发明提供含有依托汀的胶带制剂，其包含支撑膜和层压在支持膜上的压敏粘合剂层，其中压敏粘合剂层包含依达斯汀，有机胺的富马酸盐和压敏粘合剂 。

公开(公告)号：US20220273603A1

公开(公告)日：2022-09-01

申请号：US17682205

申请日：2022-02-28

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kana IMAMURA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K31/222 ,  A61K9/00 ,  A61K47/10 ,  A61K47/02

Abstract: A method for treating hyperhidrosis is disclosed. The method comprises administering a liquid topical preparation to a patient in need thereof. The liquid topical preparation comprises water and oxybutynin or a pharmaceutically acceptable salt thereof. The oxybutynin or pharmaceutically acceptable salt thereof is present in a range of, for example, from 10 mass % to 20 mass % based on a total mass of the liquid topical preparation.

公开(公告)号：US20180055783A1

公开(公告)日：2018-03-01

申请号：US15565864

申请日：2016-04-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoyuki UCHIDA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/4045 ,  A61K47/18

Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.

公开(公告)号：US20170224630A1

公开(公告)日：2017-08-10

申请号：US15518847

申请日：2015-10-13

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Junji NOGUCHI ,  Eisuke HATANAKA ,  Hisakazu KURITA ,  Ryusuke FUDOJI ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K47/06 ,  C08F226/10 ,  C09J7/02 ,  A61K31/00 ,  C08F226/02 ,  C08K5/092

CPC classification number: A61K9/7053 ,  A61K9/7061 ,  A61K31/00 ,  A61K31/485 ,  A61K47/06 ,  A61K47/10 ,  C08F226/02 ,  C08F226/10 ,  C08K5/092

Abstract: A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

公开(公告)号：US20160374956A1

公开(公告)日：2016-12-29

申请号：US15103449

申请日：2014-12-10

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Tomohiro SHINODA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K47/32 ,  A61K31/325

CPC classification number: A61K9/7084 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/137 ,  A61K31/27 ,  A61K31/325 ,  A61K31/551 ,  A61K47/32

Abstract: A multilayer-type patch comprising: a support layer; a drug reservoir layer; and an adhesive layer, wherein the drug reservoir layer comprises at least one drug selected from the group consisting of rivastigmine and pharmaceutically acceptable salts thereof, and a hydroxy group-containing acrylic-based polymer (A), the adhesive layer comprises at least one acrylic-based polymer (B) selected from the group consisting of carboxy group-containing alkyl (meth)acrylate copolymer and acrylic acid homopolymer, and a rubber-based adhesive base agent, a content of the drug in the drug reservoir layer in terms of rivastigmine in free form is 15 to 45% by mass relative to a total mass of the drug reservoir layer, and a total content of the acrylic-based polymer (B) in the adhesive layer is 7 to 18% by mass relative to a total mass of the adhesive layer.

Abstract translation: 一种装有覆盖材料的贴片，包括：贴片; 和覆盖材料，其中所述贴片包括支撑层和药物储存层，所述支撑层和药物储存层层叠在所述支撑层的一个表面上并且包含药物和药物储存剂基剂，所述覆盖材料包括覆盖层和粘合剂层 其叠层在覆盖层的一个表面上并且包含粘合剂基剂，贴片和覆盖材料以使得粘合剂层堆叠在支撑层的另一个表面上的方式布置，并且溶解度参数（SPa ），药物储库基剂的溶解度参数（SPb）和粘合剂基剂的溶解度参数（SPc）同时满足下述式（1）〜（3）所示的条件：0‰×SPa 'SPb‰¤1.5 2.0‰¤SPa'SPc‰2.8和1.0‰SPb'SPc‰2.8

公开(公告)号：US20250064754A1

公开(公告)日：2025-02-27

申请号：US18941163

申请日：2024-11-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo TANAKA ,  Hideaki OHASHI ,  Naruhide MIYOSHI ,  Takito SHIMA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US20230034383A1

公开(公告)日：2023-02-02

申请号：US17381294

申请日：2021-07-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yuka TAKAGI ,  Kazuya ISHIDA ,  Ryoma TAMURA ,  Takao KUROKAWA ,  Yasunari MICHINAKA

IPC: A61K31/407 ,  A61K9/70 ,  A61K47/06

Abstract: A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising: using an adhesive agent for preparing the adhesive agent layer, the adhesive agent containing free asenapine in a range of 2 to 5% by mass, styrene-isoprene-styrene block copolymer (SIS) in a range of 7 to 18% by mass, polyisobutylene (PIB) in a range of 0.5 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 30 to 70% by mass, and liquid paraffin in a range of 5 to 10% by mass, relative to a total amount of the adhesive agent; and preparing the asenapine-containing patch whose average cumulative amount of skin permeation of asenapine (24 hours) after applying the asenapine-containing patch to skin of a dorsal scapular region of a 5-week-old Hartley white female guinea pig and holding the asenapine-containing patch with an occlusive dressing for 24 hours is in a range of 90 to 300 μg/cm2 in terms of free form.