公开(公告)号：US20230034383A1

公开(公告)日：2023-02-02

申请号：US17381294

申请日：2021-07-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yuka TAKAGI ,  Kazuya ISHIDA ,  Ryoma TAMURA ,  Takao KUROKAWA ,  Yasunari MICHINAKA

IPC: A61K31/407 ,  A61K9/70 ,  A61K47/06

Abstract: A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising: using an adhesive agent for preparing the adhesive agent layer, the adhesive agent containing free asenapine in a range of 2 to 5% by mass, styrene-isoprene-styrene block copolymer (SIS) in a range of 7 to 18% by mass, polyisobutylene (PIB) in a range of 0.5 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 30 to 70% by mass, and liquid paraffin in a range of 5 to 10% by mass, relative to a total amount of the adhesive agent; and preparing the asenapine-containing patch whose average cumulative amount of skin permeation of asenapine (24 hours) after applying the asenapine-containing patch to skin of a dorsal scapular region of a 5-week-old Hartley white female guinea pig and holding the asenapine-containing patch with an occlusive dressing for 24 hours is in a range of 90 to 300 μg/cm2 in terms of free form.

公开(公告)号：US20210228496A1

公开(公告)日：2021-07-29

申请号：US16751307

申请日：2020-01-24

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yuka TAKAGI ,  Kazuya ISHIDA ,  Takao KUROKAWA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K47/06 ,  A61K31/407

Abstract: A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising:
using an adhesive agent for preparing the adhesive agent layer, the adhesive agent comprising free asenapine in a range of 2 to 5% by mass, isopropyl palmitate in a range of 5 to 12% by mass, styrene-isoprene-styrene block copolymer in a range of 10 to 20% by mass, polyisobutylene in a range of 3 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 50 to 70% by mass, and liquid paraffin in a range of 5 to 12% by mass, relative to a total amount of the adhesive agent; and
preparing the asenapine-containing patch having an amount of the adhesive agent layer after drying in a range of 100 to 400 g/m2.