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    METHOD FOR INHIBITING ASENAPINE DEGRADATION
    4.
    发明公开
    METHOD FOR INHIBITING ASENAPINE DEGRADATION 审中-公开

    公开(公告)号：US20230414530A1

    公开(公告)日：2023-12-28

    申请号：US18035951

    申请日：2021-11-08

    申请人： HISAMITSU PHARMACEUTICAL CO., INC.

    发明人： Yuka TAKAGI ,  Nao IWAMOTO

    IPC分类号： A61K9/70 ,  A61K47/18 ,  A61K31/407

    CPC分类号： A61K9/7046 ,  A61K47/18 ,  A61K31/407

    摘要： Disclosed is a method for inhibiting degradation of asenapine or a pharmaceutically acceptable salt thereof in a patch. The patch comprises an adhesive layer on a base, and the adhesive layer contains an adhesive base and asenapine or a pharmaceutically acceptable salt thereof. The method includes incorporating at least one amine compound selected from the group consisting of monoethanolamine, diethanolamine, diisopropanolamine, isopropanolamine, triethanolamine and meglumine in the adhesive layer.

    ASENAPINE-CONTAINING PATCH
    5.
    发明公开
    ASENAPINE-CONTAINING PATCH 审中-公开

    公开(公告)号：US20230310340A1

    公开(公告)日：2023-10-05

    申请号：US18036203

    申请日：2021-11-08

    申请人： HISAMITSU PHARMACEUTICAL CO., INC.

    发明人： Yuka TAKAGI ,  Nao IWAMOTO

    IPC分类号： A61K9/70 ,  A61K31/407 ,  A61K47/18

    CPC分类号： A61K9/7069 ,  A61K31/407 ,  A61K47/183

    摘要： Disclosed is a patch in which degradation of asenapine or a pharmaceutically acceptable salt thereof is inhibited. The patch comprises an adhesive layer on a base, wherein the adhesive layer contains an adhesive base, asenapine or a pharmaceutically acceptable salt thereof, and at least one basic amino acid selected from the group consisting of lysine, arginine and histidine, or a pharmaceutically acceptable salt of said basic amino acid.

    METHOD FOR REDUCING SKIN SENSITIZATION OF AN ASENAPINE-CONTAINING PATCH
    7.
    发明申请
    METHOD FOR REDUCING SKIN SENSITIZATION OF AN ASENAPINE-CONTAINING PATCH 有权

    公开(公告)号：US20230034383A1

    公开(公告)日：2023-02-02

    申请号：US17381294

    申请日：2021-07-21

    申请人： HISAMITSU PHARMACEUTICAL CO., INC.

    发明人： Yuka TAKAGI ,  Kazuya ISHIDA ,  Ryoma TAMURA ,  Takao KUROKAWA ,  Yasunari MICHINAKA

    IPC分类号： A61K31/407 ,  A61K9/70 ,  A61K47/06

    摘要： A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising: using an adhesive agent for preparing the adhesive agent layer, the adhesive agent containing free asenapine in a range of 2 to 5% by mass, styrene-isoprene-styrene block copolymer (SIS) in a range of 7 to 18% by mass, polyisobutylene (PIB) in a range of 0.5 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 30 to 70% by mass, and liquid paraffin in a range of 5 to 10% by mass, relative to a total amount of the adhesive agent; and preparing the asenapine-containing patch whose average cumulative amount of skin permeation of asenapine (24 hours) after applying the asenapine-containing patch to skin of a dorsal scapular region of a 5-week-old Hartley white female guinea pig and holding the asenapine-containing patch with an occlusive dressing for 24 hours is in a range of 90 to 300 μg/cm2 in terms of free form.

    METHOD FOR REDUCING SKIN SENSITIZATION OF AN ASENAPINE-CONTAINING PATCH
    8.
    发明申请
    METHOD FOR REDUCING SKIN SENSITIZATION OF AN ASENAPINE-CONTAINING PATCH 有权

    公开(公告)号：US20210228496A1

    公开(公告)日：2021-07-29

    申请号：US16751307

    申请日：2020-01-24

    申请人： HISAMITSU PHARMACEUTICAL CO., INC.

    发明人： Yuka TAKAGI ,  Kazuya ISHIDA ,  Takao KUROKAWA ,  Yasunari MICHINAKA

    IPC分类号： A61K9/70 ,  A61K47/06 ,  A61K31/407

    摘要： A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising:
    using an adhesive agent for preparing the adhesive agent layer, the adhesive agent comprising free asenapine in a range of 2 to 5% by mass, isopropyl palmitate in a range of 5 to 12% by mass, styrene-isoprene-styrene block copolymer in a range of 10 to 20% by mass, polyisobutylene in a range of 3 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 50 to 70% by mass, and liquid paraffin in a range of 5 to 12% by mass, relative to a total amount of the adhesive agent; and
    preparing the asenapine-containing patch having an amount of the adhesive agent layer after drying in a range of 100 to 400 g/m2.

    ROTIGOTINE-CONTAINING PATCH
    9.
    发明申请
    ROTIGOTINE-CONTAINING PATCH 审中-公开

    公开(公告)号：US20200306203A1

    公开(公告)日：2020-10-01

    申请号：US16954627

    申请日：2018-12-14

    申请人： HISAMITSU PHARMACEUTICAL CO., INC.

    发明人： Hiroyuki ARAKI ,  Yuka TAKAGI ,  Yoko FUJIWARA ,  Hiroaki KOBAYASHI ,  Takao KUROKAWA

    IPC分类号： A61K9/70 ,  A61K31/381

    摘要： The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof,the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, andin the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form:content of the cross-linked polyvinylpyrrolidone) is 10:3 to 1:3.