公开(公告)号：US09320728B2

公开(公告)日：2016-04-26

申请号：US14317976

申请日：2014-06-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takahito Yoshizaki ,  Kouji Tanaka ,  Kazunosuke Aida ,  Terumitsu Kaiho ,  Nobuo Tsutsumi

IPC: A61K31/4045 ,  A61K9/70

CPC classification number: A61K31/4045 ,  A61K9/7053

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.

Abstract translation: 一种贴剂的制造方法，其特征在于，在支承层的至少一个表面配置有支撑层和粘合剂层，其特征在于，包括：工序A）得到粘合剂层组合物，其含有游离罗哌尼罗， 在所得粘合剂层中为5〜13.2质量％ 步骤B）将粘合剂层组合物在50至76℃的温度下加热5分钟至24小时; 和步骤C）以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至常温，由此以溶解形式的过饱和浓度得到包含游离罗哌尼罗的粘合剂层。

公开(公告)号：US20150004215A1

公开(公告)日：2015-01-01

申请号：US14317976

申请日：2014-06-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takahito YOSHIZAKI ,  Kouji Tanaka ,  Kazunosuke Aida ,  Terumitsu Kaiho ,  Nobuo Tsutsumi

IPC: A61K31/4045 ,  A61K9/70

CPC classification number: A61K31/4045 ,  A61K9/7053

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.

Abstract translation: 一种贴剂的制造方法，其特征在于，在支承层的至少一个表面配置有支撑层和粘合剂层，其特征在于，包括：工序A）得到粘合剂层组合物，其含有游离罗哌尼罗， 在所得粘合剂层中为5〜13.2质量％ 步骤B）将粘合剂层组合物在50至76℃的温度下加热5分钟至24小时; 和步骤C）以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至常温，由此以溶解形式的过饱和浓度得到包含游离罗哌尼罗的粘合剂层。