公开(公告)号：US08877235B2

公开(公告)日：2014-11-04

申请号：US13923828

申请日：2013-06-21

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Kazunosuke Aida ,  Terumitsu Kaiho ,  Tetsurou Tateishi ,  Nobuo Tsutsumi

IPC: A61K9/70 ,  A61F13/02 ,  A61K9/00 ,  A61K31/216

CPC classification number: A61K9/0014 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/216

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier; a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70° C. for 1 to 24 hours; and a step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.

Abstract translation: 一种贴剂的制造方法，其特征在于，在支撑层的至少一个表面上配置有支撑层和粘合剂层，所述方法包括：获得包含奥昔布宁盐酸盐作为药物的粘合剂层组合物的工序A， 基于聚合物和/或基于橡胶的聚合物作为粘合剂基剂，液体石蜡，固醇，有机酸和增粘剂; 将粘合剂层组合物在55〜70℃的温度范围内加热1〜24小时的工序B; 以及以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至低于室温的温度的步骤C，从而得到包含过饱和浓度的药物的粘合剂层 一个溶解的形式。

公开(公告)号：US11202764B2

公开(公告)日：2021-12-21

申请号：US16605268

申请日：2018-04-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuya Kominami ,  Takito Shima ,  Naoyuki Uchida ,  Naoko Fujita ,  Shigeo Suzuki ,  Terumitsu Kaiho

IPC: A61K9/70 ,  A61K47/12 ,  A61P25/04 ,  A61K31/485

Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.

公开(公告)号：US09320728B2

公开(公告)日：2016-04-26

申请号：US14317976

申请日：2014-06-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takahito Yoshizaki ,  Kouji Tanaka ,  Kazunosuke Aida ,  Terumitsu Kaiho ,  Nobuo Tsutsumi

IPC: A61K31/4045 ,  A61K9/70

CPC classification number: A61K31/4045 ,  A61K9/7053

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.

Abstract translation: 一种贴剂的制造方法，其特征在于，在支承层的至少一个表面配置有支撑层和粘合剂层，其特征在于，包括：工序A）得到粘合剂层组合物，其含有游离罗哌尼罗， 在所得粘合剂层中为5〜13.2质量％ 步骤B）将粘合剂层组合物在50至76℃的温度下加热5分钟至24小时; 和步骤C）以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至常温，由此以溶解形式的过饱和浓度得到包含游离罗哌尼罗的粘合剂层。

公开(公告)号：US20150004215A1

公开(公告)日：2015-01-01

申请号：US14317976

申请日：2014-06-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takahito YOSHIZAKI ,  Kouji Tanaka ,  Kazunosuke Aida ,  Terumitsu Kaiho ,  Nobuo Tsutsumi

IPC: A61K31/4045 ,  A61K9/70

CPC classification number: A61K31/4045 ,  A61K9/7053

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.

Abstract translation: 一种贴剂的制造方法，其特征在于，在支承层的至少一个表面配置有支撑层和粘合剂层，其特征在于，包括：工序A）得到粘合剂层组合物，其含有游离罗哌尼罗， 在所得粘合剂层中为5〜13.2质量％ 步骤B）将粘合剂层组合物在50至76℃的温度下加热5分钟至24小时; 和步骤C）以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至常温，由此以溶解形式的过饱和浓度得到包含游离罗哌尼罗的粘合剂层。