公开(公告)号：US08877235B2

公开(公告)日：2014-11-04

申请号：US13923828

申请日：2013-06-21

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Kazunosuke Aida ,  Terumitsu Kaiho ,  Tetsurou Tateishi ,  Nobuo Tsutsumi

IPC: A61K9/70 ,  A61F13/02 ,  A61K9/00 ,  A61K31/216

CPC classification number: A61K9/0014 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/216

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier; a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70° C. for 1 to 24 hours; and a step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.

Abstract translation: 一种贴剂的制造方法，其特征在于，在支撑层的至少一个表面上配置有支撑层和粘合剂层，所述方法包括：获得包含奥昔布宁盐酸盐作为药物的粘合剂层组合物的工序A， 基于聚合物和/或基于橡胶的聚合物作为粘合剂基剂，液体石蜡，固醇，有机酸和增粘剂; 将粘合剂层组合物在55〜70℃的温度范围内加热1〜24小时的工序B; 以及以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至低于室温的温度的步骤C，从而得到包含过饱和浓度的药物的粘合剂层 一个溶解的形式。

公开(公告)号：US08802134B2

公开(公告)日：2014-08-12

申请号：US13772843

申请日：2013-02-21

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Naruhito Higo ,  Tetsurou Tateishi ,  Takaaki Terahara ,  Kazunosuke Aida ,  Shigeki Hayashi ,  Nobuo Tsutsumi

IPC: A61K9/00 ,  A61F13/02

CPC classification number: A61J3/00 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/216

Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.

Abstract translation: 一种具有高皮肤渗透性和高的药物物理性质如粘附性和内聚性以及长期保存性的贴剂的制造方法。 通过首先获得含有奥昔布宁和/或其盐作为药物的粘合剂层组合物，作为粘合剂的丙烯酸类聚合物和/或橡胶类聚合物，液体石蜡，有机酸和 增粘剂 在从药物的熔点到高于熔点10℃的温度的温度下加热粘合剂层组合物2〜24小时; 并缓慢冷却加热的粘合剂层组合物以获得以溶解形式的过饱和浓度的包含药物的粘合剂层。

公开(公告)号：US20140161865A1

公开(公告)日：2014-06-12

申请号：US13772843

申请日：2013-02-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naruhito Higo ,  Tetsurou Tateishi ,  Takaaki Terahara ,  Kazunosuke Aida ,  Shigeki Hayashi ,  Nobuo Tsutsumi

IPC: A61J3/00 ,  A61K31/216

CPC classification number: A61J3/00 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/216

Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.

Abstract translation: 一种具有高皮肤渗透性和高的药物物理性质如粘附性和内聚性以及长期保存性的贴剂的制造方法。 通过首先获得含有奥昔布宁和/或其盐作为药物的粘合剂层组合物，作为粘合剂的丙烯酸类聚合物和/或橡胶类聚合物，液体石蜡，有机酸和 增粘剂 在从药物的熔点到高于熔点10℃的温度的温度下加热粘合剂层组合物2〜24小时; 并缓慢冷却加热的粘合剂层组合物以获得以溶解形式的过饱和浓度的包含药物的粘合剂层。

公开(公告)号：USRE45510E1

公开(公告)日：2015-05-05

申请号：US13687376

申请日：2012-11-28

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Hideaki Iwahashi ,  Shigeo Ota ,  Nobuo Tsutsumi ,  Takafumi Miyachika

IPC: A61F13/00

CPC classification number: A61F13/00029 ,  A61F13/0259 ,  A61F2013/00289 ,  A61F2013/00812

Abstract: A patch permitting division of only its release sheet by simply pulling right and left, wherein detachment of the release sheet is easy. There is provided a patch comprising a stretchable support, a plaster applied substantially all over one major surface of the support and a release sheet attached to the whole surface of the plaster wherein only the release sheet is divided at a division zone by simply pulling right and left, and wherein one or two or more precut parts that open when the patch is pulled right and left are disposed in the neighborhood on the division zone.

Abstract translation: 一个补丁只允许通过简单地向左和向右拉动分离其释放片，其中剥离片的脱离容易。 提供了一种贴片，其包括可拉伸支撑件，基本上涂覆在支撑体的整个主表面上的石膏和附着到石膏整个表面的剥离片，其中只有剥离片在分隔区域被简单地向右拉和 左，并且其中当所述贴片被左右拉动时打开的一个或两个或更多个预切割部分设置在所述分割区域附近。

公开(公告)号：US09320728B2

公开(公告)日：2016-04-26

申请号：US14317976

申请日：2014-06-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takahito Yoshizaki ,  Kouji Tanaka ,  Kazunosuke Aida ,  Terumitsu Kaiho ,  Nobuo Tsutsumi

IPC: A61K31/4045 ,  A61K9/70

CPC classification number: A61K31/4045 ,  A61K9/7053

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.

Abstract translation: 一种贴剂的制造方法，其特征在于，在支承层的至少一个表面配置有支撑层和粘合剂层，其特征在于，包括：工序A）得到粘合剂层组合物，其含有游离罗哌尼罗， 在所得粘合剂层中为5〜13.2质量％ 步骤B）将粘合剂层组合物在50至76℃的温度下加热5分钟至24小时; 和步骤C）以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至常温，由此以溶解形式的过饱和浓度得到包含游离罗哌尼罗的粘合剂层。

公开(公告)号：US20150004215A1

公开(公告)日：2015-01-01

申请号：US14317976

申请日：2014-06-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takahito YOSHIZAKI ,  Kouji Tanaka ,  Kazunosuke Aida ,  Terumitsu Kaiho ,  Nobuo Tsutsumi

IPC: A61K31/4045 ,  A61K9/70

CPC classification number: A61K31/4045 ,  A61K9/7053

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.

Abstract translation: 一种贴剂的制造方法，其特征在于，在支承层的至少一个表面配置有支撑层和粘合剂层，其特征在于，包括：工序A）得到粘合剂层组合物，其含有游离罗哌尼罗， 在所得粘合剂层中为5〜13.2质量％ 步骤B）将粘合剂层组合物在50至76℃的温度下加热5分钟至24小时; 和步骤C）以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至常温，由此以溶解形式的过饱和浓度得到包含游离罗哌尼罗的粘合剂层。