公开(公告)号：US11850311B2

公开(公告)日：2023-12-26

申请号：US17281621

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Satoshi Amano

IPC: A61K9/70 ,  A61K31/407

CPC classification number: A61K9/7069 ,  A61K31/407

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.

公开(公告)号：US20210369637A1

公开(公告)日：2021-12-02

申请号：US17281621

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Satoshi Amano

IPC: A61K9/70 ,  A61K31/407

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.

公开(公告)号：US12151030B2

公开(公告)日：2024-11-26

申请号：US17426796

申请日：2020-01-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takao Kurokawa ,  Hidekazu Kuma ,  Masaki Yukuhiro

IPC: A61K9/70 ,  A61K31/13 ,  A61K31/27 ,  A61K31/381 ,  A61K31/403 ,  A61K31/407 ,  A61K31/4422 ,  A61K31/573

Abstract: The present invention provides a patch comprising an adhesive layer on a backing, wherein the adhesive layer contains a adhesive base, a skin irritant drug or a pharmaceutically acceptable salt thereof, and diflucortolone valerate, and the content of the diflucortolone valerate is 0.0009 to 0.08% by mass based on the total mass of the adhesive layer.

公开(公告)号：US11590106B2

公开(公告)日：2023-02-28

申请号：US17281623

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Yasunari Michinaka

IPC: A61K31/407 ,  A61K9/70 ,  A61K47/02 ,  A61K47/12 ,  A61K47/32

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.

公开(公告)号：US20210393587A1

公开(公告)日：2021-12-23

申请号：US17281623

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Yasunari Michinaka

IPC: A61K31/407 ,  A61K9/70 ,  A61K47/02 ,  A61K47/32 ,  A61K47/12

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.