公开(公告)号：US20250082591A1

公开(公告)日：2025-03-13

申请号：US18960714

申请日：2024-11-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro NAKASHIMA ,  Yusuke TANAKA ,  Keiichiro TSURUSHIMA

IPC: A61K31/167 ,  A61K9/70 ,  A61K47/10

Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or pharmaceutically acceptable salt thereof in the adhesive layer is 3 mass % to 5 mass % with respect to the total mass of the adhesive layer, the content of the terpene resin in the adhesive layer is 5 mass % to 18 mass % with respect to the total mass of the adhesive layer, and the content of propylene glycol in the adhesive layer is 3 mass % to 7 mass % with respect to the total mass of the adhesive layer, wherein crystals are not precipitated in the patch, and wherein the adhesive layer has an adhesive surface, and requires a force of 1.3 N or less to release the adhesive surfaces during self-adhesion.

公开(公告)号：US20230346720A1

公开(公告)日：2023-11-02

申请号：US18083793

申请日：2022-12-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro NAKASHIMA ,  Yusuke TANAKA ,  Keiichiro TSURUSHIMA

IPC: A61K9/70 ,  A61K31/167 ,  A61K47/10

CPC classification number: A61K31/167 ,  A61K9/7046 ,  A61K47/10

Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or a pharmaceutically acceptable salt thereof in the adhesive layer in terms of free form is 2 mass% to 6 mass% with respect to the total mass of the adhesive layer, wherein the ratio of the mass of the lidocaine or a pharmaceutically acceptable salt thereof in terms of free form to the mass of propylene glycol in the adhesive layer is 1:0.6 to 1:1.8, and wherein the content of the terpene resin in the adhesive layer is 5 mass% to 18 mass% with respect to a total mass of the adhesive layer.