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    Gel Patch
    1.
    发明申请
    Gel Patch 审中-公开
    凝胶补丁

    公开(公告)号：US20160175262A1

    公开(公告)日：2016-06-23

    申请号：US14974288

    申请日：2015-12-18

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Keiichiro TSURUSHIMA ,  Yasuhisa KOSE ,  Takaaki YOSHINAGA

    IPC: A61K9/70 ,  A61K47/14

    CPC classification number: A61K9/7061 ,  A61K31/618 ,  A61K47/14 ,  A61K47/26

    Abstract: A gel patch includes a base fabric, an adhesive layer, and a release liner in this order, wherein the adhesive layer contains a physiologically active substance, a water-soluble (meth)acrylic polymer, water, a surfactant, and poly(methyl acrylate/2-ethylhexyl acrylate), and the surfactant comprises a polyethylene glycol fatty acid ester or a polyoxyethylene sorbitan fatty acid ester.

    Abstract translation: 凝胶贴剂依次包括基底织物，粘合剂层和剥离衬垫，其中粘合剂层含有生理活性物质，水溶性（甲基）丙烯酸聚合物，水，表面活性剂和聚（丙烯酸甲酯 丙烯酸-2-乙基己酯），表面活性剂包括聚乙二醇脂肪酸酯或聚氧乙烯脱水山梨糖醇脂肪酸酯。

    COOLING SHEET
    4.
    发明申请
    COOLING SHEET 有权

    公开(公告)号：US20220125626A1

    公开(公告)日：2022-04-28

    申请号：US17430035

    申请日：2020-02-14

    Applicant: HISAMITSU PHARMACEUTICAL CO.,INC.

    Inventor： Kentaro NAKASHIMA ,  Keiichiro TSURUSHIMA ,  Takaaki YOSHINAGA

    IPC: A61F7/02 ,  C09J129/04 ,  C08K5/12

    Abstract: A cooling sheet comprising: a backing layer; an adhesive agent layer; and a liner layer for protecting the adhesive agent layer, wherein the adhesive agent layer contains water at 65 to 85% by mass based on a total mass of the adhesive agent layer, polyalkylene glycol monooleate at 0.12 to 0.7% by mass based on the total mass of the adhesive agent layer, polyvinyl alcohol at 3 to 10% by mass based on the total mass of the adhesive agent layer, polyacrylic acid at 0.5 to 5% by mass based on the total mass of the adhesive agent layer, and a parahydroxybenzoate at 0.01 to 1% by mass based on the total mass of the adhesive agent layer, and a mass ratio of a content of the polyvinyl alcohol to a content of the polyacrylic acid is in a range of 1.2:1 to 5:1.

    Cataplasm and Method for Producing the Same
    5.
    发明申请
    Cataplasm and Method for Producing the Same 审中-公开
    泥asm及其制作方法

    公开(公告)号：US20160206569A1

    公开(公告)日：2016-07-21

    申请号：US14913455

    申请日：2014-08-21

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Keiichiro TSURUSHIMA ,  Yasuhisa KOSE ,  Seiichiro TSURU ,  Shinji YAMASOTO ,  Takaaki YOSHINAGA

    IPC: A61K9/70

    CPC classification number: A61K9/7061 ,  A61L15/225 ,  A61L15/585 ,  A61L15/60 ,  C08F220/14 ,  C08L33/02 ,  C08L71/00 ,  C08L33/08 ,  C08F2220/1858

    Abstract: A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.

    Abstract translation: 一种凝胶贴片，其包含支撑体上的膏药层，所述膏药层包含至少中和的聚丙烯酸，聚（丙烯酸甲酯/丙烯酸2-乙基己酯）乳液和水的混合物，其中所述聚（丙烯酸甲酯/ 丙烯酸乙基己酯）乳液是通过在介质沸点以上加热而蒸发残留物为57〜61％的乳液，其存在量为中和的聚丙烯酸的质量的至少2.5倍，优选至少3倍 酸。

    LIDOCAINE-CONTAINING PATCH
    6.
    发明申请
    LIDOCAINE-CONTAINING PATCH 有权

    公开(公告)号：US20250082591A1

    公开(公告)日：2025-03-13

    申请号：US18960714

    申请日：2024-11-26

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Kentaro NAKASHIMA ,  Yusuke TANAKA ,  Keiichiro TSURUSHIMA

    IPC: A61K31/167 ,  A61K9/70 ,  A61K47/10

    Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or pharmaceutically acceptable salt thereof in the adhesive layer is 3 mass % to 5 mass % with respect to the total mass of the adhesive layer, the content of the terpene resin in the adhesive layer is 5 mass % to 18 mass % with respect to the total mass of the adhesive layer, and the content of propylene glycol in the adhesive layer is 3 mass % to 7 mass % with respect to the total mass of the adhesive layer, wherein crystals are not precipitated in the patch, and wherein the adhesive layer has an adhesive surface, and requires a force of 1.3 N or less to release the adhesive surfaces during self-adhesion.

    LIDOCAINE-CONTAINING PATCH
    7.
    发明公开
    LIDOCAINE-CONTAINING PATCH 审中-公开

    公开(公告)号：US20230346720A1

    公开(公告)日：2023-11-02

    申请号：US18083793

    申请日：2022-12-19

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Kentaro NAKASHIMA ,  Yusuke TANAKA ,  Keiichiro TSURUSHIMA

    IPC: A61K9/70 ,  A61K31/167 ,  A61K47/10

    CPC classification number: A61K31/167 ,  A61K9/7046 ,  A61K47/10

    Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or a pharmaceutically acceptable salt thereof in the adhesive layer in terms of free form is 2 mass% to 6 mass% with respect to the total mass of the adhesive layer, wherein the ratio of the mass of the lidocaine or a pharmaceutically acceptable salt thereof in terms of free form to the mass of propylene glycol in the adhesive layer is 1:0.6 to 1:1.8, and wherein the content of the terpene resin in the adhesive layer is 5 mass% to 18 mass% with respect to a total mass of the adhesive layer.

    PACKAGING BAG AND PATCH PACKAGING PRODUCT
    9.
    发明公开
    PACKAGING BAG AND PATCH PACKAGING PRODUCT 审中-公开

    公开(公告)号：US20240067441A1

    公开(公告)日：2024-02-29

    申请号：US18270760

    申请日：2022-02-14

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Keiichiro TSURUSHIMA ,  Shinji YAMASOTO ,  Tetsuro TATEISHI

    IPC: B65D83/08 ,  B65D75/58 ,  B65D85/62

    CPC classification number: B65D83/0805 ,  B65D75/5855 ,  B65D83/0894 ,  B65D85/62 ,  B65D2575/586

    Abstract: A packaging bag according to one example includes: a bag body configured to store a plurality of folded patches; an opening formed in the bag body; and a flap label configured to cover the opening such that the opening is capable of being opened and closed. The opening is formed such that Lp/La is 1.5 to 2.5 and Lq/Lb is 1.8 to 2.8, where La denotes a first length of the opening along a first direction, Lp denotes a first length of the folded patch along the first direction, Lb denotes a second length of the opening along a second direction orthogonal to the first direction, the second length being shorter than the first length, and Lq denotes a second length of the folded patch along the second direction.

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