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公开(公告)号：US3527750A
公开(公告)日：1970-09-08
申请号：US3527750D
申请日：1969-01-23
Applicant: HOFFMANN LA ROCHE
Inventor： KARR ANDREW E
IPC: C07H17/075 , C07C47/18
CPC classification number: C07H17/075
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2.发明授权Antibiotic production utilizing streptomyces refuineus var. thermotolerans 失效抗生素生产利用抗菌素 THERMOLOLERANS
公开(公告)号：US3619374A
公开(公告)日：1971-11-09
申请号：US3619374D
申请日：1967-12-04
Applicant: HOFFMANN LA ROCHE
Inventor： BERGER JULIUS , KARR ANDREW E , LEIMGRUBER WILLY , TABENKIN BENJAMIN , SCHOCHER ARNO JOHANNES , STEFANOVIC VLADIMIR
IPC: C12D9/00
CPC classification number: C07D498/18 , Y10S435/886
Abstract: Antibiotics having antitumor and antibacterial activity are produced by fermentation of thermophilic actimomycetes Streptomyces refuineus var. thermotolerans, having NRRL numbers 3,143 and 3,144, in a nutrient medium containing a protein source and a carbohydrate source, at 35* C. to 55* C., extracting the fermentation broth with a solvent and isolating the active fraction.
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3.发明授权5-oxo-1h-pyrrolo-[2, 1-c][1, 4]-benzodiazepin-2-crylamides 失效5-氧代-1H-吡咯并[2,1-c] [1,4] - 苯并二氮杂-2-酰胺
公开(公告)号：US3361742A
公开(公告)日：1968-01-02
申请号：US41659964
申请日：1964-12-07
Applicant: HOFFMANN LA ROCHE
Inventor： JULIUS BERGER , KARR ANDREW E , WILLY LEIMGRUBER , JOHANNES SCHOCHER ARNO , BENJAMIN TABENKIN
IPC: C07D487/04
CPC classification number: A61K31/70 , C07D487/04 , Y10S435/886
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公开(公告)号：US2676903A
公开(公告)日：1954-04-27
申请号：US14432650
申请日：1950-02-15
Applicant: HOFFMANN LA ROCHE
Inventor： GEORGE SCHEIBEL EDWARD , KARR ANDREW E
IPC: A61K31/59
CPC classification number: A61K31/59
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