公开(公告)号：US3663373A

公开(公告)日：1972-05-16

申请号：US3663373D

申请日：1970-02-24

Applicant: HOFFMANN LA ROCHE

Inventor： BERGER JULIUS ,  EPPS RICHARD H ,  JENKINS EDWARD M ,  TABENKIN BENJAMIN

IPC: C12D9/00

CPC classification number: C07D471/04 ,  Y10S435/822 ,  Y10S435/84 ,  Y10S435/886

Abstract: A method for producing iodinin through the cultivation of selected isolates of the organism Brevibacterium iodinum. Cultivation takes place in a specialized nutrient medium and the iodinin is isolated by extraction. Iodinin is a valuable chemical intermediate used in the preparation of the known pharmaceutically useful antibiotic myxin.

Abstract translation: 通过培养选择的生物体短杆菌的分离株来生产碘蛋白的方法。 培养发生在专门的营养培养基中，碘黄素通过提取分离。 碘丁素是用于制备已知的药学上有用的抗生素myxin的有价值的化学中间体。

公开(公告)号：US3619374A

公开(公告)日：1971-11-09

申请号：US3619374D

申请日：1967-12-04

Applicant: HOFFMANN LA ROCHE

Inventor： BERGER JULIUS ,  KARR ANDREW E ,  LEIMGRUBER WILLY ,  TABENKIN BENJAMIN ,  SCHOCHER ARNO JOHANNES ,  STEFANOVIC VLADIMIR

IPC: C12D9/00

CPC classification number: C07D498/18 ,  Y10S435/886

Abstract: Antibiotics having antitumor and antibacterial activity are produced by fermentation of thermophilic actimomycetes Streptomyces refuineus var. thermotolerans, having NRRL numbers 3,143 and 3,144, in a nutrient medium containing a protein source and a carbohydrate source, at 35* C. to 55* C., extracting the fermentation broth with a solvent and isolating the active fraction.