公开(公告)号：US3578565A

公开(公告)日：1971-05-11

申请号：US3578565D

申请日：1968-10-01

Applicant: HOFFMANN LA ROCHE

Inventor： SCHOCHER ARNO JOHANNES ,  FURST ANDOR ,  ELS HANS ,  BECHER ELISABETH ,  GROSS GISELA

IPC: C12P33/16 ,  C07J1/00 ,  C12P33/00 ,  C07C167/18

CPC classification number: C12P33/00 ,  Y10S435/911

Abstract: MICROBIOLOGICAL PROCESS FOR PREPARING 17-OXYGENATED ANDROSTANES BY SUBJECTING 20-OXYGENATED PREGNANES TO THE ACTION OF A CULTURE OF THE FUNGUS GLIOCLADIUM ROSEUM. THE STEROIDS PREPARED ARE KNOW COMPOUNDS WHICH ARE PHARMACEUTICALLY USEFUL AS ANDROGENIC AGENTS AND AS INTERMEDIATES WHICH CAN BE CONVERTED TO KNOWN COMPOUNDS WHICH ARE PROGESTATIONAL AGENTS.

公开(公告)号：US3891504A

公开(公告)日：1975-06-24

申请号：US39901973

申请日：1973-09-20

Applicant: HOFFMANN LA ROCHE

Inventor： SCHOCHER ARNO JOHANNES ,  WISS OSWALD

IPC: C12P23/00 ,  C12D13/02

CPC classification number: C12P23/00 ,  Y10S435/803 ,  Y10S435/85

Abstract: A process for obtaining zeaxanthin by fermentation utilizing one of two bacterial species which belong to the genus Flavobacter and which are deposited under ATCC 21,588 and ATCC 21,081.

Abstract translation: 通过发酵使用属于黄杆菌属的两种细菌物种之一并根据ATCC 21,588和ATCC 21,081保藏的玉米黄质的方法。

公开(公告)号：US3634461A

公开(公告)日：1972-01-11

申请号：US3634461D

申请日：1970-02-09

Applicant: HOFFMANN LA ROCHE

Inventor： BECHER ELISABETH ,  ELS HANS ,  SCHOCHER ARNO JOHANNES

IPC: C07D493/10 ,  C07J75/00 ,  C07C167/00 ,  C07C167/14 ,  C07C173/06

CPC classification number: C07D493/10 ,  C07J75/00 ,  Y10S435/911

Abstract: THE SPIROSTAN DERIVATIVE 1,2,3,4,10,19-HEXANOR-5-OXO5,9-SECO-25D-SPIROSTAN-5-OIC ACID IS OBTAINED BY THE MICROBIOLOGICAL DEGRADATION OF DISOGENIN UTILIZING PROACTINOMYCES RESTRICTUS TURFITT CBS 157.45 OR ENZYMES DERIVED THEREFROM. THE AFORESAID SPIROSTAN DERIVATIVE IS USEFUL AS AN INTERMEDIATE IN THE SYNTHESIS OF MEDICINALLY VALUABLE 9B,10A-STEROIDS AND NORSTEROIDS.

公开(公告)号：US3700702A

公开(公告)日：1972-10-24

申请号：US3700702D

申请日：1970-12-02

Applicant: HOFFMANN LA ROCHE

Inventor： FURST ANDOR ,  MULLER MARCEL ,  MULLER PETER ,  SCHOCHER ARNO JOHANNES ,  BECHER ELISABETH

IPC: C07J53/00 ,  C07J75/00 ,  C07C169/32

CPC classification number: C07J53/00 ,  C07J75/00

Abstract: A new series of 15 Beta ,16 Beta -methylene pregnanes is disclosed and methods for their preparation are described. The compounds are particularly useful as antiinflammatory agents.

Abstract translation: 公开了一系列新的15β，16β-亚甲基孕烷，并描述了其制备方法。 该化合物特别可用作抗炎剂。

公开(公告)号：US3619374A

公开(公告)日：1971-11-09

申请号：US3619374D

申请日：1967-12-04

Applicant: HOFFMANN LA ROCHE

Inventor： BERGER JULIUS ,  KARR ANDREW E ,  LEIMGRUBER WILLY ,  TABENKIN BENJAMIN ,  SCHOCHER ARNO JOHANNES ,  STEFANOVIC VLADIMIR

IPC: C12D9/00

CPC classification number: C07D498/18 ,  Y10S435/886

Abstract: Antibiotics having antitumor and antibacterial activity are produced by fermentation of thermophilic actimomycetes Streptomyces refuineus var. thermotolerans, having NRRL numbers 3,143 and 3,144, in a nutrient medium containing a protein source and a carbohydrate source, at 35* C. to 55* C., extracting the fermentation broth with a solvent and isolating the active fraction.