公开(公告)号：US11224564B2

公开(公告)日：2022-01-18

申请号：US16635423

申请日：2018-09-11

Applicant: HOSEO UNIVERSITY ACADEMIC COOPERATION FOUNDATION

Inventor： Hwan-Myung Lee ,  Dae-Il Hwang ,  Do-Yoon Kim ,  Soo-Min Park ,  Ha-Bin Kim

IPC: A61K36/28 ,  A61Q19/00 ,  A61K8/64 ,  A61K8/92 ,  A61K38/48

Abstract: Disclosed are a pharmaceutical composition and a beauty-purposed pharmaceutical composition for prevention or treatment of neuromuscular disease, the composition including a combination of Erigeron annuus flower-based essential oil and Botox. Erigeron annuus flower-based essential oil inhibits t-SNARE protein and v-SNARE protein expression in neurons to inhibit the formation of SNARE protein complexes. Erigeron annuus flower-based essential oil inhibits the regeneration of t-SNARE protein and v-SNARE protein degraded by Botox to inhibit neurotransmitter release. Accordingly, an efficacy duration of Botox may be extended. Thus, Erigeron annuus flower-based essential oil may be usefully used in combination with Botox as Botox adjuvant for the prevention and treatment of neuromuscular disease or for beauty.