公开(公告)号：US20170050966A1

公开(公告)日：2017-02-23

申请号：US15305892

申请日：2015-04-23

申请人： HYDRA BIOSCIENCES, INC.

发明人： Blaise S. Lippa ,  Xinyuan Wu ,  Qingyi Li ,  Iwona Wrona ,  Andrew J. Jackson ,  Bertrand L. Chenard ,  Christopher Matthew Liu ,  Guohua Liang ,  Matthew F. Baevsky ,  Richard Alan Earl ,  Lisa Mcqueen ,  Jared Smit ,  Brett A. Cowans

IPC分类号： C07D473/08

CPC分类号： C07D473/08 ,  C07B2200/13

摘要： The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition thereof, and their use for the treatment of pain, inflammatory disease, neuropathy, dermatological disorders, pulmonary conditions, and cough, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，药物制剂或其药物组合物及其用于治疗疼痛，炎性疾病，神经病，皮肤病，肺病和咳嗽的用途， 以及抑制瞬态受体电位A1离子通道（TRPA1）。

公开(公告)号：US20180230149A1

公开(公告)日：2018-08-16

申请号：US15940253

申请日：2018-03-29

申请人： Hydra Biosciences, Inc.

发明人： Blaise S. Lippa ,  Xinyuan Wu ,  Qingyi Li ,  Iwona Wrona ,  Andrew J. Jackson ,  Bertrand L. Chenard ,  Christopher M. Liu ,  Guohua Liang ,  Matthew F. Baevsky ,  Richard A. Earl ,  Lisa Mcqueen ,  Jared Smit ,  Brett A. Cowans

IPC分类号： C07D473/08

CPC分类号： C07D473/08 ,  C07B2200/13

摘要： The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition thereof, and their use for the treatment of pain, inflammatory disease, neuropathy, dermatological disorders, pulmonary conditions, and cough, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).