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公开(公告)号：US20190169167A1
公开(公告)日：2019-06-06
申请号：US16170154
申请日：2018-10-25
发明人： Thierry Bouyssou , Dirk Gottschling , Niklas Heine , Lana Louise Smith Keenan , Michael D. Lowe , Hossein Razavi , Christopher Ronald Sarko , Simon Surprenant , Hidenori Takahashi , Michael Robert Turner , Xinyuan Wu
IPC分类号： C07D401/14 , C07D487/08 , C07D498/08 , C07D451/02
摘要： The invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R7, A, Y and L are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US20180051020A1
公开(公告)日：2018-02-22
申请号：US15337907
申请日：2016-10-28
发明人： Xinyuan Wu , Spencer David Kimball , Ping Chen , Ding Zhou , Shaoping Peng
IPC分类号： C07D471/04 , A61K31/519 , C07D239/70
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70
摘要： Compounds and compositions for treating disorders related to TRPA1 are described herein.
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公开(公告)号：US20170050966A1
公开(公告)日：2017-02-23
申请号：US15305892
申请日：2015-04-23
发明人： Blaise S. Lippa , Xinyuan Wu , Qingyi Li , Iwona Wrona , Andrew J. Jackson , Bertrand L. Chenard , Christopher Matthew Liu , Guohua Liang , Matthew F. Baevsky , Richard Alan Earl , Lisa Mcqueen , Jared Smit , Brett A. Cowans
IPC分类号： C07D473/08
CPC分类号： C07D473/08 , C07B2200/13
摘要： The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition thereof, and their use for the treatment of pain, inflammatory disease, neuropathy, dermatological disorders, pulmonary conditions, and cough, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，药物制剂或其药物组合物及其用于治疗疼痛，炎性疾病，神经病，皮肤病，肺病和咳嗽的用途， 以及抑制瞬态受体电位A1离子通道（TRPA1）。
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公开(公告)号：US09505756B2
公开(公告)日：2016-11-29
申请号：US14616100
申请日：2015-02-06
发明人： Xinyuan Wu , Spencer David Kimball , Ping Chen , Ding Zhou , Shaoping Peng
IPC分类号： C07D239/70 , C07D487/04 , C07D471/04 , A61K31/519
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70
摘要： Compounds and compositions for treating disorders related to TRPA1 are described herein.
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公开(公告)号：US10221177B2
公开(公告)日：2019-03-05
申请号：US15512213
申请日：2015-09-18
发明人： Bertrand L. Chenard , Xinyuan Wu
IPC分类号： C07D473/06 , A61K31/52 , C07D473/08 , A61K9/20 , C07K14/705 , A61K31/00
摘要： The present invention relates to pharmaceutical compounds of the Formula (I), or a pharmaceutically acceptable salt or composition thereof, and methods of their use for the treatment of pain, respiratory conditions, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).
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公开(公告)号：US20180230149A1
公开(公告)日：2018-08-16
申请号：US15940253
申请日：2018-03-29
发明人： Blaise S. Lippa , Xinyuan Wu , Qingyi Li , Iwona Wrona , Andrew J. Jackson , Bertrand L. Chenard , Christopher M. Liu , Guohua Liang , Matthew F. Baevsky , Richard A. Earl , Lisa Mcqueen , Jared Smit , Brett A. Cowans
IPC分类号： C07D473/08
CPC分类号： C07D473/08 , C07B2200/13
摘要： The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition thereof, and their use for the treatment of pain, inflammatory disease, neuropathy, dermatological disorders, pulmonary conditions, and cough, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).
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公开(公告)号：US20190169168A1
公开(公告)日：2019-06-06
申请号：US16170178
申请日：2018-10-25
发明人： Thierry Bouyssou , Dirk Gottschling , Niklas Heine , Lana Louise Smith Keenan , Michael D. Lowe , Hossein Razavi , Christopher Ronald Sarko , Simon Surprenant , Hidenori Takahashi , Michael Robert Turner , Xinyuan Wu
IPC分类号： C07D401/14 , C07D487/08 , C07D498/08 , C07D451/02
摘要： The invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R7, A, Y and L are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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