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    Compositions, methods and kits for diagnosis of carriers of mutations in the BRCA1 and BRCA2 genes and early diagnosis of cancerous disorders associated with mutations in BRCA1 and BRCA 2 genes
    1.
    发明申请
    Compositions, methods and kits for diagnosis of carriers of mutations in the BRCA1 and BRCA2 genes and early diagnosis of cancerous disorders associated with mutations in BRCA1 and BRCA 2 genes 审中-公开
    用于诊断BRCA1和BRCA2基因突变载体的组合物，方法和试剂盒以及与BRCA1和BRCA2基因突变相关的癌性疾病的早期诊断

    公开(公告)号：US20150354014A1

    公开(公告)日：2015-12-10

    申请号：US14834989

    申请日：2015-08-25

    Applicant: Hadasit Medical Research Services and Development Ltd.

    Inventor： Asher SALMON ,  Tamar PERETZ

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

    Abstract: The present invention relates to diagnostic compositions methods and kits for the detection of carriers of mutations in the BRCA1 and BRCA2 genes. The detection is based on the use of detecting nucleic acids or amino acid based molecules, specific for determination of the expression of at least six marker genes of the invention, in a test sample. The invention thereby provides methods compositions and kits for the diagnosis of cancerous disorders associated with mutations in the BRCA1 and BRCA2 genes, specifically, of ovarian and breast cancer.

    Abstract translation: 本发明涉及用于检测BRCA1和BRCA2基因突变载体的诊断组合物方法和试剂盒。 检测是基于在测试样品中使用检测核酸或基于氨基酸的分子，其特异性用于测定本发明的至少六个标记基因的表达。 因此，本发明提供了用于诊断与BRCA1和BRCA2基因，特别是卵巢癌和乳腺癌中的突变相关的癌性病症的方法组合物和试剂盒。

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