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1.发明申请Compositions, methods and kits for diagnosis of carriers of mutations in the BRCA1 and BRCA2 genes and early diagnosis of cancerous disorders associated with mutations in BRCA1 and BRCA 2 genes 审中-公开用于诊断BRCA1和BRCA2基因突变载体的组合物，方法和试剂盒以及与BRCA1和BRCA2基因突变相关的癌性疾病的早期诊断公开(公告)号：US20150354014A1
公开(公告)日：2015-12-10
申请号：US14834989
申请日：2015-08-25
Inventor： Asher SALMON , Tamar PERETZ
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/156 , C12Q2600/158
Abstract: The present invention relates to diagnostic compositions methods and kits for the detection of carriers of mutations in the BRCA1 and BRCA2 genes. The detection is based on the use of detecting nucleic acids or amino acid based molecules, specific for determination of the expression of at least six marker genes of the invention, in a test sample. The invention thereby provides methods compositions and kits for the diagnosis of cancerous disorders associated with mutations in the BRCA1 and BRCA2 genes, specifically, of ovarian and breast cancer.
Abstract translation: 本发明涉及用于检测BRCA1和BRCA2基因突变载体的诊断组合物方法和试剂盒。 检测是基于在测试样品中使用检测核酸或基于氨基酸的分子，其特异性用于测定本发明的至少六个标记基因的表达。 因此，本发明提供了用于诊断与BRCA1和BRCA2基因，特别是卵巢癌和乳腺癌中的突变相关的癌性病症的方法组合物和试剂盒。
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公开(公告)号：US20180187269A1
公开(公告)日：2018-07-05
申请号：US15896902
申请日：2018-02-14
Inventor： Asher SALMON , Tamar PERETZ
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/156 , C12Q2600/158
Abstract: The present invention relates to diagnostic compositions methods and kits for the detection of carriers of mutations in the BRCA1 and BRCA2 genes. The detection is based on the use of detecting nucleic acids or amino acid based molecules, specific for determination of the expression of at least six marker genes of the invention, in a test sample. The invention thereby provides methods compositions and kits for the diagnosis of cancerous disorders associated with mutations in the BRCA1 and BRCA2 genes, specifically, of ovarian and breast cancer.
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公开(公告)号：US20160175416A1
公开(公告)日：2016-06-23
申请号：US15051205
申请日：2016-02-23
Inventor： Tamar PERETZ , Michal LOTEM , Arthur MACHLENKIN , Shoshana FRANKENBURG , Inna BEN DAVID , Anna KUZNETZ , Yael GELFAND , Galit EISENBERG , Merav DARASH YAHANA
CPC classification number: A61K39/0011 , A61K2039/5152 , C12N5/0693 , C12Q1/6886 , G01N33/57492
Abstract: The present invention relates to cancer immunotherapy, specifically to allogeneic tumor cell vaccines. According to some embodiments, the invention provides novel cell lines useful as therapeutic cell vaccine compositions. The invention further provides advantageous screening methods and means for identifying patients amenable for treatment with partially Human Leukocyte Antigen (HLA) matched allogeneic cell vaccines. Therapeutic compositions and methods for use in proliferative disorders are further provided.
Abstract translation: 本发明涉及癌症免疫治疗，特别涉及同种异体肿瘤细胞疫苗。 根据一些实施方案，本发明提供可用作治疗性细胞疫苗组合物的新型细胞系。 本发明还提供了有利的筛选方法和手段，用于鉴定适合用部分人白细胞抗原（HLA）匹配的同种异体细胞疫苗治疗的患者。 进一步提供用于增殖性疾病的治疗组合物和方法。
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