公开(公告)号：US20220233477A1

公开(公告)日：2022-07-28

申请号：US17618541

申请日：2020-06-11

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Benjamin Eithan REUBINOFF ,  Etti BEN-SHUSHAN

IPC: A61K31/166 ,  C12N5/079 ,  A61P9/10 ,  A61P37/06 ,  A61P25/28

Abstract: A method of generating human mature oligodendrocytes is disclosed. The method comprises contacting a cell population which comprises human pre-oligodendrocytes with an inhibitor of the MAPK/ERK pathway under conditions that allow the pre-oligodendrocytes to differentiate into mature oligodendrocytes. Use of the MAPK/ERK pathway inhibitor for treating diseases is also disclosed.