公开(公告)号：US20160175416A1

公开(公告)日：2016-06-23

申请号：US15051205

申请日：2016-02-23

Applicant: Hadasit Medical Research Services and Development Ltd.

Inventor： Tamar PERETZ ,  Michal LOTEM ,  Arthur MACHLENKIN ,  Shoshana FRANKENBURG ,  Inna BEN DAVID ,  Anna KUZNETZ ,  Yael GELFAND ,  Galit EISENBERG ,  Merav DARASH YAHANA

IPC: A61K39/00 ,  C12N5/09

CPC classification number: A61K39/0011 ,  A61K2039/5152 ,  C12N5/0693 ,  C12Q1/6886 ,  G01N33/57492

Abstract: The present invention relates to cancer immunotherapy, specifically to allogeneic tumor cell vaccines. According to some embodiments, the invention provides novel cell lines useful as therapeutic cell vaccine compositions. The invention further provides advantageous screening methods and means for identifying patients amenable for treatment with partially Human Leukocyte Antigen (HLA) matched allogeneic cell vaccines. Therapeutic compositions and methods for use in proliferative disorders are further provided.

Abstract translation: 本发明涉及癌症免疫治疗，特别涉及同种异体肿瘤细胞疫苗。 根据一些实施方案，本发明提供可用作治疗性细胞疫苗组合物的新型细胞系。 本发明还提供了有利的筛选方法和手段，用于鉴定适合用部分人白细胞抗原（HLA）匹配的同种异体细胞疫苗治疗的患者。 进一步提供用于增殖性疾病的治疗组合物和方法。